STRINGSTRING
MTOR MTOR E2F2 E2F2 JAK1 JAK1 GNAI3 GNAI3 NRAS NRAS CREB3L4 CREB3L4 IL6R IL6R FASLG FASLG PTGS2 PTGS2 TRAF5 TRAF5 GNG4 GNG4 CALML5 CALML5 HRAS HRAS CREB3L1 CREB3L1 GNG3 GNG3 RPS6KB2 RPS6KB2 FADD FADD SP1 SP1 TBK1 TBK1 RB1 RB1 ADCY4 ADCY4 NFKBIA NFKBIA PTGER2 PTGER2 B2M B2M GNB5 GNB5 ADCY9 ADCY9 PRKCB PRKCB CX3CL1 CX3CL1 TP53 TP53 RPS6KB1 RPS6KB1 GNA13 GNA13 PRKCA PRKCA GRB2 GRB2 MAP2K2 MAP2K2 CREB3L3 CREB3L3 CALR CALR PRKACA PRKACA PIK3R2 PIK3R2 ARHGEF1 ARHGEF1 CALM3 CALM3 PRKCG PRKCG ADCY3 ADCY3 IL1B IL1B CASP8 CASP8 PLCB1 PLCB1 PLCB4 PLCB4 E2F1 E2F1 BID BID MAPK1 MAPK1 ATF4 ATF4 ITPR2 ITPR2 ITPR1 ITPR1 CCR5 CCR5 RHOA RHOA GNAI2 GNAI2 ADCY5 ADCY5 PIK3CB PIK3CB GNB4 GNB4 PDGFRA PDGFRA CXCL8 CXCL8 NFKB1 NFKB1 PTGER4 PTGER4 RIPK1 RIPK1 TAPBP TAPBP ITPR3 ITPR3 MAPK14 MAPK14 GNA12 GNA12 CYCS CYCS ADCY1 ADCY1 CDK6 CDK6 GNGT1 GNGT1 GNG11 GNG11 CREB3L2 CREB3L2 PTK2B PTK2B IKBKB IKBKB IFNB1 IFNB1 IFNA21 IFNA21 IFNA2 IFNA2 IFNA5 IFNA5 PRKACG PRKACG GNG10 GNG10 ELK1 ELK1 CDK4 CDK4 CCR3 CCR3 AKAP13 AKAP13 PRKACB PRKACB IL10RB IL10RB SOS2 SOS2 CALML6 CALML6 TAP1 TAP1 CTNNB1 CTNNB1 GNB3 GNB3 STING1 STING1 TRADD TRADD CRKL CRKL NFATC2 NFATC2 ITGAV ITGAV GNAQ GNAQ CREB3 CREB3 BAK1 BAK1 PDIA3 PDIA3 SOS1 SOS1 MAPK3 MAPK3 CGAS CGAS CASP3 CASP3 RELA RELA PATR-F PATR-F MAPK12 MAPK12 PATR-G PATR-G CCL3 CCL3 ATF6B ATF6B ARHGEF12 ARHGEF12 CCL4 CCL4 GNAS GNAS CDKN1A CDKN1A GNGT2 GNGT2 IFNA6 IFNA6 MAP2K6 MAP2K6 GNG12 GNG12 ADCY7 ADCY7 GNG13 GNG13 LOC104003639 LOC104003639 MAP2K1 MAP2K1 ROCK2 ROCK2 TSC1 TSC1 ATF2 ATF2 PIK3R3 PIK3R3 LOC107972317 LOC107972317 CALML3 CALML3 PPP3CB PPP3CB PATR-B PATR-B GNG2 GNG2 TNFRSF1A TNFRSF1A ENSPTRP00000066786 ENSPTRP00000066786 GNB1 GNB1 E2F3 E2F3 PPP3CA PPP3CA CXCL12 CXCL12 IL6 IL6 ITGB3 ITGB3 PATR-AL PATR-AL IFNA17 IFNA17 CCL2 CCL2 GNG7 GNG7 EGFR EGFR IFNA14 IFNA14 GNAI1 GNAI1 CREB1 CREB1 GNA11 GNA11 PPP3CC PPP3CC MAPK11 MAPK11 CXCR4 CXCR4 IL1R1 IL1R1 PTGER3 PTGER3 MYC MYC CXCR2 CXCR2 LOC100610002 LOC100610002 SRC SRC PIK3R1 PIK3R1 CCR1 CCR1 ADCY8 ADCY8 CREB5 CREB5 BCAR1 BCAR1 CK820_G0014527 CK820_G0014527 GSK3B GSK3B LOC104002760 LOC104002760 AKT1 AKT1 CCL5 CCL5 CRK CRK ADCY2 ADCY2 CHUK CHUK IFNA8 IFNA8 KRAS KRAS IL10RA IL10RA TAP2 TAP2 ROCK1 ROCK1 LOC741747 LOC741747 GNB2 GNB2 PLCB3 PLCB3 AKT3 AKT3 CCND1 CCND1 NFATC3 NFATC3 PTGER1 PTGER1 RHEB RHEB GNAO1 GNAO1 LOC455004 LOC455004 NFATC4 NFATC4 LOC742651 LOC742651 CASP9 CASP9 AKT2 AKT2 GNG8 GNG8 ARHGEF11 ARHGEF11 STAT3 STAT3 BAX BAX VEGFA VEGFA LOC742456 LOC742456 PATR-E PATR-E ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
E2F2E2F transcription factor 2. (437 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
IL6RInterleukin 6 receptor. (442 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CALML5Calmodulin like 5. (146 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SP1Sp1 transcription factor. (786 aa)
TBK1TANK-binding kinase 1. (729 aa)
RB1RB transcriptional corepressor 1. (928 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
PTGER2Prostaglandin E receptor 2 (Subtype EP2), 53kDa; Belongs to the G-protein coupled receptor 1 family. (358 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa)
GNB5GNB5 isoform 1. (409 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GNA13Guanine nucleotide binding protein (G protein), alpha 13. (377 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
CALRCalreticulin. (414 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
E2F1E2F transcription factor 1. (437 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
RHOARas homolog family member A. (193 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family. (490 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
TAPBPTAP binding protein. (466 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
GNA12Guanine nucleotide binding protein (G protein) alpha 12. (381 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
IFNB1Interferon beta 1. (187 aa)
IFNA21Interferon alpha 21. (189 aa)
IFNA2IFNA2 isoform 1. (170 aa)
IFNA5Interferon alpha 5. (189 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNG10Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10. (68 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
IL10RBInterleukin 10 receptor, beta. (325 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML6Calmodulin like 6. (181 aa)
TAP1TAP1 isoform 1. (808 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GNB3G protein subunit beta 3. (340 aa)
STING1TMEM173 isoform 2. (379 aa)
TRADDTNFRSF1A-associated via death domain. (312 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
NFATC2NFATC2 isoform 4. (938 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CGASMB21D1 isoform 1. (520 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
PATR-FPatr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system. (442 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (92 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
CCL4C-C motif chemokine. (92 aa)
GNASGNAS isoform 19. (1042 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
IFNA6Interferon alpha 6. (190 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
TSC1TSC complex subunit 1. (1164 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
LOC107972317Cytochrome c-like. (102 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PPP3CBSerine/threonine-protein phosphatase. (526 aa)
PATR-BPatr class I histocompatibility antigen, C alpha chain; Involved in the presentation of foreign antigens to the immune system. (397 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
TNFRSF1ATumor necrosis factor receptor superfamily, member 1A. (455 aa)
ENSPTRP00000066786LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain. (191 aa)
GNB1Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
E2F3E2F transcription factor 3. (465 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
PATR-ALMajor histocompatibility complex, class I, AL precursor. (365 aa)
IFNA17IFNA17 isoform 1. (189 aa)
CCL2C-C motif chemokine. (109 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IFNA14Interferon alpha 14. (189 aa)
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. (422 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
PPP3CCSerine/threonine-protein phosphatase. (521 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
IL1R1Interleukin 1 receptor, type I. (569 aa)
PTGER3Prostaglandin E receptor 3. (418 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (360 aa)
LOC100610002IKBKG isoform 9. (401 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CREB5CREB5 isoform 1. (508 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
CK820_G0014527IFNA13 isoform 2. (198 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
LOC104002760Cytochrome c. (110 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CCL5C-C motif chemokine. (91 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
IFNA8Interferon alpha 8. (189 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
TAP2Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP). (724 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
LOC741747IFNA7 isoform 1. (189 aa)
GNB2Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
PTGER1Prostaglandin E receptor 1. (402 aa)
RHEBRHEB isoform 1. (184 aa)
GNAO1G protein subunit alpha o1. (354 aa)
LOC455004CCL4L2 isoform 3. (103 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
LOC742651IFNA1 isoform 1. (195 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 11. (1562 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
BAXBAX isoform 7. (123 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
LOC742456Cytochrome c-like. (105 aa)
PATR-EPatr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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