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| | E2F2 | E2F transcription factor 2. (437 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | VIM | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa) |
| | BLNK | BLNK isoform 2. (456 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | DDB2 | Damage-specific DNA binding protein 2, 48kDa. (427 aa) |
| | PSMC3 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 3; Belongs to the AAA ATPase family. (446 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | CD3E | CD3E isoform 2. (207 aa) |
| | CD3G | CD3G isoform 1. (182 aa) |
| | CCND2 | CCND2 isoform 1; Belongs to the cyclin family. (289 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4. (460 aa) |
| | TBK1 | TANK-binding kinase 1. (729 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa. (1087 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa) |
| | PSMC1 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; Belongs to the AAA ATPase family. (440 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (96 aa) |
| | PSMD7 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7. (324 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | PSMD11 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11. (422 aa) |
| | PSMD3 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (534 aa) |
| | CALR | Calreticulin. (414 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | PSMD8 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 8. (350 aa) |
| | PSMD14 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14. (310 aa) |
| | CASP8 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (449 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | RBPJL | Recombination signal binding protein for immunoglobulin kappa J region like. (517 aa) |
| | ADRM1 | Adhesion regulating molecule 1. (407 aa) |
| | IFNAR1 | Interferon (Alpha, beta and omega) receptor 1. (558 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | PSMD6 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6. (441 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | CXCL10 | C-X-C motif chemokine. (96 aa) |
| | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa) |
| | CCNA2 | CCNA2 isoform 1; Belongs to the cyclin family. (432 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | SAP30 | Sin3A-associated protein, 30kDa. (220 aa) |
| | SKP2 | S-phase kinase-associated protein 2 (P45). (425 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | RIPK1 | Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa) |
| | PATR-DRA | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | HLA-DQB1 | HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3. (261 aa) |
| | PATR-DOB | Patr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM. (273 aa) |
| | PATR-DMB | HLA-DMB isoform 5. (263 aa) |
| | MAMU-DMA | HLA class II histocompatibility antigen, DM alpha chain isoform X1. (290 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa) |
| | HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) |
| | TAPBP | TAP binding protein. (466 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | NFKBIE | NFKB inhibitor epsilon. (500 aa) |
| | TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3. (790 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | CDK6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | PSMC2 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family. (433 aa) |
| | IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | IFNA21 | Interferon alpha 21. (189 aa) |
| | IFNA2 | IFNA2 isoform 1. (170 aa) |
| | IFNA5 | Interferon alpha 5. (189 aa) |
| | DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (925 aa) |
| | GADD45G | Growth arrest and DNA-damage-inducible, gamma. (159 aa) |
| | BTK | BTK isoform 2. (693 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | CD58 | CD58 isoform 1. (250 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | CD247 | CD247 isoform 2. (163 aa) |
| | TAP1 | TAP1 isoform 1. (808 aa) |
| | TRADD | TNFRSF1A-associated via death domain. (312 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | ENTPD8 | ENTPD8 isoform 2; Belongs to the GDA1/CD39 NTPase family. (257 aa) |
| | TYK2 | Tyrosine-protein kinase. (1184 aa) |
| | FCER2 | Fc fragment of IgE receptor II. (321 aa) |
| | HDAC2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa) |
| | OAS2 | 2',5'-oligoadenylate synthetase 2. (719 aa) |
| | OAS1 | Oligoadenylate synthetase 1 isoform p46. (442 aa) |
| | BAK1 | BCL2-antagonist/killer 1. (211 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | ITGAL | ITGAL isoform 4. (344 aa) |
| | CCNE2 | CCNE2 isoform 1; Belongs to the cyclin family. (404 aa) |
| | IFNAR2 | Interferon alpha/beta receptor 2 isoform X4. (519 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | RELA | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa) |
| | LOC104006793 | HLA class II histocompatibility antigen, DR beta 3 chain precursor. (289 aa) |
| | PATR-F | Patr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system. (442 aa) |
| | HLA-DQA1 | HLA-DQA2 isoform 1; Belongs to the MHC class II family. (255 aa) |
| | IRF9 | Interferon regulatory factor 9. (391 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (370 aa) |
| | PSMC5 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa) |
| | PATR-G | Patr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | NFKBIB | NFKB inhibitor beta. (270 aa) |
| | PATR-DQB1 | HLA-DRB1 isoform 1. (271 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | ISG15 | ISG15 ubiquitin-like modifier. (165 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | ENSPTRP00000061486 | Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | LOC107972317 | Cytochrome c-like. (102 aa) |
| | SNW1 | SNW domain containing 1. (571 aa) |
| | PATR-B | Patr class I histocompatibility antigen, C alpha chain; Involved in the presentation of foreign antigens to the immune system. (397 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa) |
| | SAP30L | SAP30L isoform 1. (183 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (900 aa) |
| | ENSPTRP00000066786 | LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain. (191 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) |
| | CD40 | CD40 molecule, TNF receptor superfamily member 5. (277 aa) |
| | PATR-AL | Major histocompatibility complex, class I, AL precursor. (365 aa) |
| | IFNA17 | IFNA17 isoform 1. (189 aa) |
| | CCND3 | CCND3 isoform 1; Belongs to the cyclin family. (292 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | CCNA1 | CCNA1 isoform 3; Belongs to the cyclin family. (421 aa) |
| | IFNA14 | Interferon alpha 14. (189 aa) |
| | PSMD13 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (399 aa) |
| | GADD45B | Growth arrest and DNA-damage-inducible, beta. (160 aa) |
| | IRF7 | Interferon regulatory factor 7. (516 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | IKBKE | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (716 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1121 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | LOC100610002 | IKBKG isoform 9. (401 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | CD19 | CD19 isoform 1. (557 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (500 aa) |
| | PSMD12 | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (480 aa) |
| | CK820_G0014527 | IFNA13 isoform 2. (198 aa) |
| | LOC104002760 | Cytochrome c. (110 aa) |
| | BV7-9 | TRBV7-9 isoform 1. (155 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | ICAM1 | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa) |
| | IFNA8 | Interferon alpha 8. (189 aa) |
| | POLK | Polymerase (DNA directed) kappa. (897 aa) |
| | TAP2 | Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP). (724 aa) |
| | LOC741747 | IFNA7 isoform 1. (189 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1319 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) |
| | PSMC4 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family. (421 aa) |
| | SEM1-2 | SEM1 isoform 9. (99 aa) |
| | CCNE1 | CCNE1 isoform 1; Belongs to the cyclin family. (411 aa) |
| | RELB | RELB isoform 3. (567 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2514 aa) |
| | LOC742651 | IFNA1 isoform 1. (195 aa) |
| | CASP9 | CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | PSMC6 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (411 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | PSMD4 | PSMD4 isoform 2. (382 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa) |
| | BAX | BAX isoform 7. (123 aa) |
| | LOC742456 | Cytochrome c-like. (105 aa) |
| | PATR-E | Patr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa) |
