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UBR4 UBR4 CDC20 CDC20 JAK1 JAK1 GTF2B GTF2B NRAS NRAS CREB3L4 CREB3L4 MAPKAPK2 MAPKAPK2 TRAF5 TRAF5 LOC469702 LOC469702 EGR2 EGR2 HRAS HRAS CREB3L1 CREB3L1 CCND2 CCND2 LTBR LTBR CDKN1B CDKN1B LOC457262 LOC457262 RB1 RB1 NFKBIA NFKBIA TBPL2 TBPL2 PSMC1 PSMC1 TRAF3 TRAF3 GTF2A2 GTF2A2 VAC14 VAC14 YWHAE YWHAE TP53 TP53 KAT2A KAT2A HDAC5 HDAC5 GRB2 GRB2 CREB3L3 CREB3L3 C3 C3 PRKACA PRKACA PIK3R2 PIK3R2 HPN HPN YWHAQ YWHAQ CASP8 CASP8 SP100 SP100 RBL1 RBL1 RBPJL RBPJL RANBP1-2 RANBP1-2 MAPK1 MAPK1 YWHAH YWHAH ATF4 ATF4 EP300 EP300 HDAC10 HDAC10 KAT2B KAT2B CCR4 CCR4 CCR5 CCR5 RHOA RHOA GTF2E1 GTF2E1 PIK3CB PIK3CB RASA2 RASA2 NFKB1 NFKB1 CCNA2 CCNA2 SKP2 SKP2 GTF2H2C GTF2H2C HDAC3 HDAC3 HIST1H2BA HIST1H2BA HIST1H2BB HIST1H2BB LOC462501 LOC462501 HIST1H1E HIST1H1E H2BC11 H2BC11 MRPS18B MRPS18B GTF2H4 GTF2H4 SRF SRF TBPL1 TBPL1 HDAC9 HDAC9 YWHAG YWHAG CDK6 CDK6 CREB3L2 CREB3L2 EGR3 EGR3 POLB POLB ATP6V0D2 ATP6V0D2 PRKACG PRKACG TRAF1 TRAF1 GSN GSN HDAC6 HDAC6 SND1 SND1 GTF2E2 GTF2E2 CDK4 CDK4 CCR3 CCR3 PRKACB PRKACB TRADD TRADD LYN LYN CREB3 CREB3 HDAC2 HDAC2 GTF2H3 GTF2H3 BAK1 BAK1 H2BC13 H2BC13 CDK1 CDK1 H2BC21 H2BC21 H2BC18 H2BC18 YWHAB YWHAB CCNE2 CCNE2 MAPK3 MAPK3 CASP3 CASP3 RELA RELA PATR-F PATR-F IRF9 IRF9 PATR-G PATR-G MAD1L1 MAD1L1 ATF6B ATF6B TBP TBP LOC473712 LOC473712 CDKN1A CDKN1A LOC473843 LOC473843 HNRNPK HNRNPK LOC462508 LOC462508 LOC104002294 LOC104002294 ATF2 ATF2 PIK3R3 PIK3R3 DDX3X DDX3X SNW1 SNW1 IL6ST IL6ST PATR-B PATR-B EIF2AK2 EIF2AK2 NFKB2 NFKB2 DLG1 DLG1 ENSPTRP00000066786 ENSPTRP00000066786 CHEK1 CHEK1 DNAJA3 DNAJA3 ENSPTRP00000068204 ENSPTRP00000068204 PATR-AL PATR-AL CCND3 CCND3 RBL2 RBL2 LOC471880 LOC471880 CCNA1 CCNA1 H2BC9 H2BC9 H2BC5 H2BC5 CREB1 CREB1 HDAC4 HDAC4 IRF7 IRF7 YWHAZ YWHAZ VDAC3 VDAC3 SYK SYK CREBBP CREBBP HDAC1 HDAC1 USP7 USP7 LOC100610002 LOC100610002 SRC SRC PIK3R1 PIK3R1 UBE3A UBE3A CREB5 CREB5 CDC42 CDC42 RBPJ RBPJ ACTN4 ACTN4 PMAIP1 PMAIP1 DDB1 DDB1 HDAC8 HDAC8 CDKN2B CDKN2B CHD4 CHD4 KRAS KRAS HDAC11 HDAC11 H2BC14 H2BC14 LOC462509 LOC462509 REL REL CCND1 CCND1 CCNE1 CCNE1 H2BU1 H2BU1 HDAC7 HDAC7 GTF2A1 GTF2A1 PKM PKM STAT3 STAT3 SCIN-2 SCIN-2 BAX BAX PATR-E PATR-E BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5183 aa)
CDC20Cell division cycle 20 homolog. (499 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
GTF2BGeneral transcription factor IIB. (310 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
LOC469702Histone H2B type 3-A. (126 aa)
EGR2Early growth response 2. (476 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
LTBRLymphotoxin beta receptor (TNFR superfamily, member 3). (435 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
LOC457262HIST1H4A isoform 1. (103 aa)
RB1RB transcriptional corepressor 1. (928 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
TBPL2TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity). (375 aa)
PSMC1Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; Belongs to the AAA ATPase family. (440 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
C3Complement component 3. (465 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
HPNHPN isoform 1; Belongs to the peptidase S1 family. (417 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (253 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
SP100Nuclear autoantigen Sp-100. (885 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
RANBP1-2RANBP1 isoform 4. (200 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
EP300E1A binding protein p300. (2175 aa)
HDAC10Histone deacetylase 10. (669 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
RHOARas homolog family member A. (193 aa)
GTF2E1General transcription factor IIE, polypeptide 1, alpha 56kDa. (439 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RASA2RAS p21 protein activator 2. (849 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
SKP2S-phase kinase-associated protein 2 (P45). (425 aa)
GTF2H2CGeneral transcription factor IIH subunit. (395 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
HIST1H2BAHIST1H2BA isoform 1. (127 aa)
HIST1H2BBHIST1H2BB isoform 1. (126 aa)
LOC462501HIST1H2BK isoform 1. (126 aa)
HIST1H1EHistone cluster 1 H1 family member e. (219 aa)
H2BC11HIST1H2BJ isoform 1. (126 aa)
MRPS18B28S ribosomal protein S18b, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily. (258 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (462 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Belongs to the 14-3-3 family. (247 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
EGR3Early growth response 3. (387 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
TRAF1TNF receptor-associated factor. (416 aa)
GSNGSN isoform 3. (782 aa)
HDAC6Histone deacetylase 6. (146 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
TRADDTNFRSF1A-associated via death domain. (312 aa)
LYNTyrosine-protein kinase. (512 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
GTF2H3General transcription factor IIH, polypeptide 3, 34kDa. (308 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
H2BC21HIST2H2BE isoform 1. (126 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (134 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
CCNE2CCNE2 isoform 1; Belongs to the cyclin family. (404 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
PATR-FPatr class I histocompatibility antigen, CH28 alpha chain; Involved in the presentation of foreign antigens to the immune system. (442 aa)
IRF9Interferon regulatory factor 9. (391 aa)
PATR-GPatr class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. (371 aa)
MAD1L1MAD1 mitotic arrest deficient-like 1. (718 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
TBPTBP isoform 1. (336 aa)
LOC473712H2BFWT isoform 1. (175 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
LOC473843Histone H2B type W-T-like. (153 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K. (464 aa)
LOC462508Histone H2B type 1-N. (167 aa)
LOC104002294LOW QUALITY PROTEIN: pyruvate kinase PKM-like. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
SNW1SNW domain containing 1. (571 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
PATR-BPatr class I histocompatibility antigen, C alpha chain; Involved in the presentation of foreign antigens to the immune system. (397 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
ENSPTRP00000066786LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain. (191 aa)
CHEK1CHEK1 isoform 10. (485 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
ENSPTRP0000006820414-3-3 protein homolog 1-like. (78 aa)
PATR-ALMajor histocompatibility complex, class I, AL precursor. (365 aa)
CCND3CCND3 isoform 1; Belongs to the cyclin family. (292 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
LOC471880Histone H2B; Belongs to the histone H2B family. (126 aa)
CCNA1CCNA1 isoform 3; Belongs to the cyclin family. (421 aa)
H2BC9HIST1H2BH isoform 1. (126 aa)
H2BC5HIST1H2BD isoform 1. (126 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
IRF7Interferon regulatory factor 7. (516 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Belongs to the 14-3-3 family. (245 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
SYKTyrosine-protein kinase. (635 aa)
CREBBPCREB binding protein. (2442 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1121 aa)
LOC100610002IKBKG isoform 9. (401 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
CREB5CREB5 isoform 1. (508 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
ACTN4Actinin, alpha 4. (931 aa)
PMAIP1PMAIP1 isoform 2. (134 aa)
DDB1Damage-specific DNA binding protein 1, 127kDa. (1147 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (396 aa)
CDKN2BCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1912 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
HDAC11HDAC11 isoform 14. (374 aa)
H2BC14HIST1H2BM isoform 1. (126 aa)
LOC462509HIST1H2BO isoform 1. (126 aa)
RELREL isoform 1. (619 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CCNE1CCNE1 isoform 1; Belongs to the cyclin family. (411 aa)
H2BU1HIST3H2BB isoform 1. (126 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
GTF2A1General transcription factor IIA, 1, 19/37kDa. (366 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
SCIN-2SCIN isoform 2. (715 aa)
BAXBAX isoform 7. (123 aa)
PATR-EPatr class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. (360 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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