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MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) | ||||
HSPG2 | HSPG2 isoform 1. (4390 aa) | ||||
NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) | ||||
FASLG | FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa) | ||||
TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) | ||||
WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) | ||||
ANK3 | ANK3 isoform 5. (4377 aa) | ||||
PLAU | Plasminogen activator, urokinase. (431 aa) | ||||
HPSE2 | Heparanase 2 (inactive). (592 aa) | ||||
HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) | ||||
RRAS2 | Related RAS viral (R-ras) oncogene homolog 2. (204 aa) | ||||
RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa) | ||||
WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) | ||||
PAK1 | Non-specific serine/threonine protein kinase. (553 aa) | ||||
FZD4 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa) | ||||
CBL | Cas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa) | ||||
WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) | ||||
NANOG | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa) | ||||
WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) | ||||
WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) | ||||
ITGA5 | ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa) | ||||
CD63 | Tetraspanin. (238 aa) | ||||
ERBB3 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa) | ||||
LUM | LUM isoform 1. (338 aa) | ||||
DCN | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (359 aa) | ||||
FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) | ||||
HIF1A | Hypoxia inducible factor 1 subunit alpha. (850 aa) | ||||
IQGAP1 | IQ motif containing GTPase activating protein 1. (1657 aa) | ||||
IGF1R | Tyrosine-protein kinase receptor. (1364 aa) | ||||
NUDT16L1 | Nudix hydrolase 16 like 1. (192 aa) | ||||
PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) | ||||
VTN | VTN isoform 1. (478 aa) | ||||
FZD2 | FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa) | ||||
WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) | ||||
COL1A1 | Collagen type I alpha 1 chain. (1464 aa) | ||||
RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) | ||||
DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) | ||||
PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) | ||||
GRB2 | Growth factor receptor-bound protein 2. (217 aa) | ||||
MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) | ||||
VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) | ||||
PRKACA | PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa) | ||||
PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) | ||||
TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) | ||||
ARHGEF1 | Rho guanine nucleotide exchange factor 1. (968 aa) | ||||
RRAS | Related RAS viral (R-ras) oncogene homolog. (218 aa) | ||||
PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) | ||||
HOXD10 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa) | ||||
FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) | ||||
WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) | ||||
IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) | ||||
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa) | ||||
MMP9 | Matrix metallopeptidase 9. (699 aa) | ||||
TIAM1 | T-cell lymphoma invasion and metastasis 1. (1591 aa) | ||||
MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) | ||||
TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) | ||||
ITPR2 | Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa) | ||||
ITPR1 | ITPR1 isoform 3. (2700 aa) | ||||
CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) | ||||
RHOA | Ras homolog family member A. (193 aa) | ||||
HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (484 aa) | ||||
MRAS | Muscle RAS oncogene homolog. (208 aa) | ||||
PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) | ||||
KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) | ||||
GAB1 | GRB2-associated-binding protein 1. (724 aa) | ||||
TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) | ||||
HBEGF | Heparin-binding EGF-like growth factor. (208 aa) | ||||
IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa) | ||||
ITPR3 | ITPR3 isoform 1. (2677 aa) | ||||
MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) | ||||
ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) | ||||
COL1A2 | Collagen type I alpha 2 chain. (1366 aa) | ||||
CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) | ||||
WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) | ||||
WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) | ||||
SMO | SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa) | ||||
FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) | ||||
SDC2 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa) | ||||
PRKACG | Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa) | ||||
CTSL | CTSL isoform 2; Belongs to the peptidase C1 family. (333 aa) | ||||
TLR4 | Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa) | ||||
ELK1 | ELK1, member of ETS oncogene family. (428 aa) | ||||
PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) | ||||
FZD6 | Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) | ||||
SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) | ||||
CTNNB1 | Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa) | ||||
ANK1 | ANK1 isoform 1. (1897 aa) | ||||
ANK2 | ANK2 isoform 1. (3957 aa) | ||||
PPP1R12A | Protein phosphatase 1 regulatory subunit. (1030 aa) | ||||
FLNC | Filamin C, gamma. (2725 aa) | ||||
HSPB2 | Heat shock protein family B (small) member 2; Belongs to the small heat shock protein (HSP20) family. (182 aa) | ||||
FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) | ||||
ITGAV | Integrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa) | ||||
PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) | ||||
WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) | ||||
ITGB5 | Integrin beta; Belongs to the integrin beta chain family. (799 aa) | ||||
SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) | ||||
MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) | ||||
WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa) | ||||
CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) | ||||
PLAUR | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). (335 aa) | ||||
PLCE1 | Phosphoinositide phospholipase C. (2301 aa) | ||||
MAPK12 | Mitogen-activated protein kinase. (370 aa) | ||||
ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa) | ||||
ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa) | ||||
WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) | ||||
CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) | ||||
RPS6 | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa) | ||||
CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa) | ||||
PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa) | ||||
SMAD2 | Mothers against decapentaplegic homolog. (467 aa) | ||||
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) | ||||
ERBB4 | Receptor protein-tyrosine kinase. (1386 aa) | ||||
WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) | ||||
ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) | ||||
FLNA | FLNA isoform 8. (2711 aa) | ||||
WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) | ||||
TFAP4 | Transcription factor AP-4 (Activating enhancer binding protein 4). (338 aa) | ||||
PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) | ||||
WNT7A | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa) | ||||
FGFR1 | Fibroblast growth factor receptor. (854 aa) | ||||
SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa) | ||||
THBS1 | Thrombospondin 1. (1173 aa) | ||||
SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa) | ||||
FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa) | ||||
IGF1 | Insulin-like growth factor 1 (Somatomedin C). (196 aa) | ||||
ITGB3 | Integrin beta-3 isoform X2. (837 aa) | ||||
GPC3 | Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa) | ||||
PPP1CB | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa) | ||||
EGFR | Receptor protein-tyrosine kinase. (1210 aa) | ||||
ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (801 aa) | ||||
ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) | ||||
HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa) | ||||
RDX | RDX isoform 3. (609 aa) | ||||
CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (666 aa) | ||||
MAPK11 | Mitogen-activated protein kinase. (364 aa) | ||||
MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) | ||||
SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) | ||||
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) | ||||
SRC | Tyrosine-protein kinase. (542 aa) | ||||
DROSHA | Drosha, ribonuclease type III. (1380 aa) | ||||
PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) | ||||
CDC42 | Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa) | ||||
PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa) | ||||
IGF2 | Insulin like growth factor 2. (236 aa) | ||||
BRAF | BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa) | ||||
WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) | ||||
GPC1 | GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa) | ||||
PPP1R12B | Protein phosphatase 1 regulatory subunit. (1043 aa) | ||||
CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) | ||||
PDCD4 | Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa) | ||||
ITGA2 | Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa) | ||||
AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) | ||||
MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa) | ||||
SDC4 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa) | ||||
ARAF | V-raf murine sarcoma 3611 viral oncogene homolog. (606 aa) | ||||
VAV2 | Vav guanine nucleotide exchange factor 2. (878 aa) | ||||
KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) | ||||
ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa) | ||||
AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) | ||||
CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) | ||||
WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) | ||||
MSN | MSN isoform 1. (577 aa) | ||||
PTCH1 | PTCH1 isoform 8. (1428 aa) | ||||
MMP2 | Matrix metallopeptidase 2. (660 aa) | ||||
FZD1 | FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa) | ||||
FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) | ||||
WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa) | ||||
LOC473484 | Cathepsin L1. (276 aa) | ||||
FLNB | Filamin B, beta. (2633 aa) | ||||
AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) | ||||
VAV3 | VAV3 isoform 2. (927 aa) | ||||
FRS2 | Fibroblast growth factor receptor substrate 2. (521 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (790 aa) | ||||
VEGFA | Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa) | ||||
EIF4B | Eukaryotic translation initiation factor 4B. (615 aa) | ||||
PPP1R12C | Protein phosphatase 1 regulatory subunit. (793 aa) | ||||
EZR | EZR isoform 1. (671 aa) |