STRINGSTRING
MTOR MTOR HSPG2 HSPG2 NRAS NRAS FASLG FASLG TGFB2 TGFB2 WNT9A WNT9A ANK3 ANK3 PLAU PLAU HPSE2 HPSE2 HRAS HRAS RRAS2 RRAS2 RPS6KB2 RPS6KB2 WNT11 WNT11 PAK1 PAK1 FZD4 FZD4 CBL CBL WNT5B WNT5B NANOG NANOG WNT10B WNT10B WNT1 WNT1 ITGA5 ITGA5 CD63 CD63 ERBB3 ERBB3 LUM LUM DCN DCN FZD10 FZD10 HIF1A HIF1A IQGAP1 IQGAP1 IGF1R IGF1R NUDT16L1 NUDT16L1 PRKCB PRKCB TP53 TP53 VTN VTN FZD2 FZD2 WNT3 WNT3 COL1A1 COL1A1 RPS6KB1 RPS6KB1 DDX5 DDX5 PRKCA PRKCA GRB2 GRB2 MAP2K2 MAP2K2 VAV1 VAV1 PRKACA PRKACA PIK3R2 PIK3R2 TGFB1 TGFB1 ARHGEF1 ARHGEF1 RRAS RRAS PRKCG PRKCG HOXD10 HOXD10 FZD5 FZD5 WNT10A WNT10A IHH IHH PLCG1 PLCG1 MMP9 MMP9 TIAM1 TIAM1 MAPK1 MAPK1 TIMP3 TIMP3 ITPR2 ITPR2 ITPR1 ITPR1 CAV3 CAV3 RHOA RHOA HCLS1 HCLS1 MRAS MRAS PIK3CB PIK3CB KDR KDR GAB1 GAB1 TLR2 TLR2 HBEGF HBEGF IL12B IL12B ITPR3 ITPR3 MAPK14 MAPK14 ESR1 ESR1 COL1A2 COL1A2 CAV1 CAV1 WNT2 WNT2 WNT16 WNT16 SMO SMO FZD3 FZD3 SDC2 SDC2 PRKACG PRKACG CTSL CTSL TLR4 TLR4 ELK1 ELK1 PRKACB PRKACB FZD6 FZD6 SOS2 SOS2 CTNNB1 CTNNB1 ANK1 ANK1 ANK2 ANK2 PPP1R12A PPP1R12A FLNC FLNC HSPB2 HSPB2 FZD9 FZD9 ITGAV ITGAV PTPN6 PTPN6 WNT3A WNT3A ITGB5 ITGB5 SOS1 SOS1 MAPK3 MAPK3 WNT2B WNT2B CASP3 CASP3 PLAUR PLAUR PLCE1 PLCE1 MAPK12 MAPK12 ARHGEF12 ARHGEF12 ACTB ACTB WNT9B WNT9B CDKN1A CDKN1A RPS6 RPS6 CAV2 CAV2 PTPN11 PTPN11 SMAD2 SMAD2 MAP2K1 MAP2K1 ERBB4 ERBB4 WNT4 WNT4 ROCK2 ROCK2 FLNA FLNA WNT7B WNT7B TFAP4 TFAP4 PIK3R3 PIK3R3 WNT7A WNT7A FGFR1 FGFR1 SDC1 SDC1 THBS1 THBS1 SLC9A1 SLC9A1 FGF2 FGF2 IGF1 IGF1 ITGB3 ITGB3 GPC3 GPC3 PPP1CB PPP1CB EGFR EGFR ITGB1 ITGB1 ERBB2 ERBB2 HGF HGF RDX RDX CAMK2B CAMK2B MAPK11 MAPK11 MYC MYC SHH SHH PLCG2 PLCG2 SRC SRC DROSHA DROSHA PIK3R1 PIK3R1 CDC42 CDC42 PPP1CC PPP1CC IGF2 IGF2 BRAF BRAF WNT6 WNT6 GPC1 GPC1 PPP1R12B PPP1R12B CAMK2A CAMK2A PDCD4 PDCD4 ITGA2 ITGA2 AKT1 AKT1 MET MET SDC4 SDC4 ARAF ARAF VAV2 VAV2 KRAS KRAS ROCK1 ROCK1 AKT3 AKT3 CCND1 CCND1 WNT5A WNT5A MSN MSN PTCH1 PTCH1 MMP2 MMP2 FZD1 FZD1 FZD7 FZD7 WNT8A WNT8A LOC473484 LOC473484 FLNB FLNB AKT2 AKT2 VAV3 VAV3 FRS2 FRS2 STAT3 STAT3 VEGFA VEGFA EIF4B EIF4B PPP1R12C PPP1R12C EZR EZR
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
HSPG2HSPG2 isoform 1. (4390 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ANK3ANK3 isoform 5. (4377 aa)
PLAUPlasminogen activator, urokinase. (431 aa)
HPSE2Heparanase 2 (inactive). (592 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
RRAS2Related RAS viral (R-ras) oncogene homolog 2. (204 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
CD63Tetraspanin. (238 aa)
ERBB3V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa)
LUMLUM isoform 1. (338 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (359 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
NUDT16L1Nudix hydrolase 16 like 1. (192 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
VTNVTN isoform 1. (478 aa)
FZD2FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
RRASRelated RAS viral (R-ras) oncogene homolog. (218 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
TIAM1T-cell lymphoma invasion and metastasis 1. (1591 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RHOARas homolog family member A. (193 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ITPR3ITPR3 isoform 1. (2677 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
CTSLCTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
ANK1ANK1 isoform 1. (1897 aa)
ANK2ANK2 isoform 1. (3957 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
FLNCFilamin C, gamma. (2725 aa)
HSPB2Heat shock protein family B (small) member 2; Belongs to the small heat shock protein (HSP20) family. (182 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
PLAURUrokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). (335 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
MAPK12Mitogen-activated protein kinase. (370 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12. (1544 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
FLNAFLNA isoform 8. (2711 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TFAP4Transcription factor AP-4 (Activating enhancer binding protein 4). (338 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
THBS1Thrombospondin 1. (1173 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
GPC3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
RDXRDX isoform 3. (609 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SRCTyrosine-protein kinase. (542 aa)
DROSHADrosha, ribonuclease type III. (1380 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
IGF2Insulin like growth factor 2. (236 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GPC1GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1043 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PDCD4Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MSNMSN isoform 1. (577 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
LOC473484Cathepsin L1. (276 aa)
FLNBFilamin B, beta. (2633 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
VAV3VAV3 isoform 2. (927 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
EIF4BEukaryotic translation initiation factor 4B. (615 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (793 aa)
EZREZR isoform 1. (671 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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