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| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (174 aa) |
| | NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) |
| | MCL1 | Myeloid cell leukemia sequence 1 (BCL2-related). (350 aa) |
| | EFNA4 | EFNA4 isoform 1; Belongs to the ephrin family. (201 aa) |
| | EFNA3 | Ephrin-A3 isoform X1. (238 aa) |
| | EFNA1 | EFNA1 isoform 2; Belongs to the ephrin family. (205 aa) |
| | TNN | TNN isoform 1. (1299 aa) |
| | TNR | TNR isoform 1. (1358 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa) |
| | SLC45A3 | Solute carrier family 45, member 3. (553 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | VIM | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa) |
| | SIRT1 | SIRT1 isoform 2. (751 aa) |
| | DDIT4 | DNA-damage-inducible transcript 4. (232 aa) |
| | PLAU | Plasminogen activator, urokinase. (431 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | CCND2 | CCND2 isoform 1; Belongs to the cyclin family. (289 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa) |
| | ITGA5 | ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa) |
| | ERBB3 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa) |
| | GLS2 | GLS2 isoform 4. (602 aa) |
| | SLC7A1 | Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 1. (629 aa) |
| | SPRY2 | Sprouty homolog 2. (338 aa) |
| | IRS2 | IRS2 isoform 1. (1340 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (198 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (211 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (577 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | RPTOR | Regulatory associated protein of MTOR, complex 1. (1324 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | NOTCH3 | NOTCH3 isoform 1. (2321 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | HOXD10 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa) |
| | GLS | GLS isoform 1. (669 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa) |
| | MMP9 | Matrix metallopeptidase 9. (699 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | EP300 | E1A binding protein p300. (2175 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | PDGFRA | T0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa) |
| | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa) |
| | APC | Adenomatous polyposis coli protein isoform X10. (2844 aa) |
| | CCNG1 | CCNG1 isoform 2; Belongs to the cyclin family. (295 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa) |
| | MARCKS | Myristoylated alanine-rich protein kinase C substrate. (332 aa) |
| | FSCN1 | Fascin. (493 aa) |
| | ABCB1 | ATP binding cassette subfamily B member 1. (1280 aa) |
| | CDK6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa) |
| | RECK | Reversion-inducing-cysteine-rich protein with kazal motifs. (965 aa) |
| | TNC | TNC isoform 1. (2201 aa) |
| | NOTCH1 | NOTCH1 isoform 1. (2555 aa) |
| | BMF | Bcl2 modifying factor. (184 aa) |
| | CDC25B | Cell division cycle 25 homolog B. (580 aa) |
| | TPM1 | TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa) |
| | RASSF1 | Ras association (RalGDS/AF-6) domain family member 1. (340 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | DICER1 | Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | CRKL | V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa) |
| | CDC25C | CDC25C isoform 7. (508 aa) |
| | EFNA2 | EFNA2 isoform 1; Belongs to the ephrin family. (190 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (375 aa) |
| | HDAC2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa) |
| | BAK1 | BCL2-antagonist/killer 1. (211 aa) |
| | SOX4 | Transcription factor SOX. (474 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) |
| | TRIM71 | Tripartite motif containing 71. (868 aa) |
| | HMGA2 | High mobility group AT-hook 2. (147 aa) |
| | SHC1 | SHC (Src homology 2 domain containing) transforming protein 1. (584 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | CCNE2 | CCNE2 isoform 1; Belongs to the cyclin family. (404 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | NOTCH4 | NOTCH4 isoform 3. (2006 aa) |
| | PDGFA | PDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K. (464 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1127 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1674 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | THBS1 | Thrombospondin 1. (1173 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | ITGB3 | Integrin beta-3 isoform X2. (837 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa) |
| | RDX | RDX isoform 3. (609 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | FOXP1 | FOXP1 isoform 2. (693 aa) |
| | ZFPM2 | ZFPM2 isoform 3. (1151 aa) |
| | MMP16 | Matrix metallopeptidase 16 (Membrane-inserted). (609 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1530 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | NOTCH2 | NOTCH2 isoform 1. (2612 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | BMI1 | BMI1 isoform 1. (326 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | PDCD4 | Programmed cell death 4 (Neoplastic transformation inhibitor). (469 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa) |
| | CRK | V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa) |
| | KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa) |
| | CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) |
| | CK820_G0006908 | TNXB isoform 2. (3702 aa) |
| | CCNE1 | CCNE1 isoform 1; Belongs to the cyclin family. (411 aa) |
| | APC2 | APC2 isoform 1. (2301 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (808 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (593 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | EZH2-2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa) |
| | ST14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | VEGFA | Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1253 aa) |
| | EZR | EZR isoform 1. (671 aa) |
