(61 nodes) Renal cell carcinoma network (Pan troglodytes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
	PRCC	Papillary renal cell carcinoma (Translocation-associated). (491 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	FH	Fumarate hydratase. (510 aa)
	HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
	PAK1	Non-specific serine/threonine protein kinase. (553 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	LOC744141	Elongin-C-like. (115 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	EPAS1	Endothelial PAS domain protein 1. (870 aa)
	PAK5	Non-specific serine/threonine protein kinase. (719 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	RBX1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	EP300	E1A binding protein p300. (2175 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	GAB1	GRB2-associated-binding protein 1. (724 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	EGLN2	T0107007 isoform 1. (407 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (789 aa)
	CRKL	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
	ENSPTRP00000060850	Elongin-B-like. (117 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	EGLN1	EGLN1 isoform 1. (426 aa)
	PAK3	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
	CUL2	CUL2 isoform 8; Belongs to the cullin family. (764 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
	RAP1B	Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
	ELOB-2	Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B). (118 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
	ARNT2	ARNT2 isoform 2. (759 aa)
	CREBBP	CREB binding protein. (2442 aa)
	FLCN	T0180863 isoform 1. (579 aa)
	VHL	Von Hippel-Lindau tumor suppressor. (213 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
	CDC42	Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
	SLC2A1	Solute carrier family 2 (Facilitated glucose transporter), member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
	LOC107968511	Elongin-C-like. (112 aa)
	BRAF	BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
	ELOC	Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Belongs to the SKP1 family. (112 aa)
	AKT1	AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	CRK	V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
	ARAF	V-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ETS1	ETS proto-oncogene 1, transcription factor. (485 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	PAK4	Non-specific serine/threonine protein kinase. (593 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSPTRP00000082849	ENSPTRP00000089692	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.988
AKT1	AKT3	ENSPTRP00000082849	ENSPTRP00000086046	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.951
AKT1	ARAF	ENSPTRP00000082849	ENSPTRP00000083580	AKT1 isoform 3; Belongs to the protein kinase superfamily.	V-raf murine sarcoma 3611 viral oncogene homolog.	0.521
AKT1	ARNT	ENSPTRP00000082849	ENSPTRP00000045337	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Aryl hydrocarbon receptor nuclear translocator.	0.531
AKT1	BAD	ENSPTRP00000082849	ENSPTRP00000093875	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Bcl2-associated agonist of cell death.	0.995
AKT1	BRAF	ENSPTRP00000082849	ENSPTRP00000079485	AKT1 isoform 3; Belongs to the protein kinase superfamily.	BRAF isoform 1; Belongs to the protein kinase superfamily.	0.523
AKT1	CDC42	ENSPTRP00000082849	ENSPTRP00000077648	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.958
AKT1	CDKN1A	ENSPTRP00000082849	ENSPTRP00000060292	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	0.995
AKT1	CREBBP	ENSPTRP00000082849	ENSPTRP00000074980	AKT1 isoform 3; Belongs to the protein kinase superfamily.	CREB binding protein.	0.655
AKT1	CRK	ENSPTRP00000082849	ENSPTRP00000083173	AKT1 isoform 3; Belongs to the protein kinase superfamily.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.653
AKT1	CRKL	ENSPTRP00000082849	ENSPTRP00000046677	AKT1 isoform 3; Belongs to the protein kinase superfamily.	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.	0.416
AKT1	EP300	ENSPTRP00000082849	ENSPTRP00000024841	AKT1 isoform 3; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.904
AKT1	EPAS1	ENSPTRP00000082849	ENSPTRP00000020413	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Endothelial PAS domain protein 1.	0.538
AKT1	ETS1	ENSPTRP00000082849	ENSPTRP00000087497	AKT1 isoform 3; Belongs to the protein kinase superfamily.	ETS proto-oncogene 1, transcription factor.	0.421
AKT1	GAB1	ENSPTRP00000082849	ENSPTRP00000028277	AKT1 isoform 3; Belongs to the protein kinase superfamily.	GRB2-associated-binding protein 1.	0.458
AKT1	GRB2	ENSPTRP00000082849	ENSPTRP00000016382	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Growth factor receptor-bound protein 2.	0.777
AKT1	HGF	ENSPTRP00000082849	ENSPTRP00000072810	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.689
AKT1	HIF1A	ENSPTRP00000082849	ENSPTRP00000010887	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Hypoxia inducible factor 1 subunit alpha.	0.719
AKT1	HRAS	ENSPTRP00000082849	ENSPTRP00000005495	AKT1 isoform 3; Belongs to the protein kinase superfamily.	V-Ha-ras Harvey rat sarcoma viral oncogene homolog.	0.752
AKT1	KRAS	ENSPTRP00000082849	ENSPTRP00000084588	AKT1 isoform 3; Belongs to the protein kinase superfamily.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.752