STRINGSTRING
MTOR MTOR E2F2 E2F2 NRAS NRAS CREB3L4 CREB3L4 PLAU PLAU HRAS HRAS CREB3L1 CREB3L1 MMP3 MMP3 CDKN1B CDKN1B FOXO1 FOXO1 RB1 RB1 NFKBIA NFKBIA SPINT1 SPINT1 IGF1R IGF1R TP53 TP53 GRB2 GRB2 MAP2K2 MAP2K2 CREB3L3 CREB3L3 PIK3R2 PIK3R2 IL1R2 IL1R2 E2F1 E2F1 MMP9 MMP9 TMPRSS2 TMPRSS2 MAPK1 MAPK1 PDGFB PDGFB ATF4 ATF4 EP300 EP300 PIK3CB PIK3CB ETV5 ETV5 PDGFRA PDGFRA NFKB1 NFKB1 EGF EGF HSP90AB1 HSP90AB1 CREB3L2 CREB3L2 IKBKB IKBKB SOS2 SOS2 CTNNB1 CTNNB1 GSTP1 GSTP1 CREB3 CREB3 SOS1 SOS1 CCNE2 CCNE2 MAPK3 MAPK3 RELA RELA PDGFA PDGFA CDKN1A CDKN1A ZEB1 ZEB1 MAP2K1 MAP2K1 PIK3R3 PIK3R3 FGFR1 FGFR1 KLK3 KLK3 E2F3 E2F3 IGF1 IGF1 LOC457015 LOC457015 EGFR EGFR ERBB2 ERBB2 HSP90AA1 HSP90AA1 INSRR INSRR CREB1 CREB1 CREBBP CREBBP LOC100610002 LOC100610002 AR AR PIK3R1 PIK3R1 CREB5 CREB5 HSP90B1 HSP90B1 PDGFD PDGFD ERG ERG BRAF BRAF LEF1 LEF1 PDGFRB PDGFRB NKX3-1 NKX3-1 TCF7 TCF7 GSK3B GSK3B AKT1 AKT1 ARAF ARAF CHUK CHUK KRAS KRAS AKT3 AKT3 CCND1 CCND1 CCNE1 CCNE1 LOC107968084 LOC107968084 CASP9 CASP9 AKT2 AKT2 BCL2 BCL2 PDGFC PDGFC BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
E2F2E2F transcription factor 2. (437 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
CREB3L4cAMP responsive element binding protein 3-like 4. (395 aa)
PLAUPlasminogen activator, urokinase. (431 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
MMP3Matrix metallopeptidase 3 (Stromelysin 1, progelatinase). (477 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
FOXO1FOXO1 isoform 1. (655 aa)
RB1RB transcriptional corepressor 1. (928 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
SPINT1SPINT1 isoform 2. (529 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
E2F1E2F transcription factor 1. (437 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
EP300E1A binding protein p300. (2175 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ETV5ETV5 isoform 1. (510 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CCNE2CCNE2 isoform 1; Belongs to the cyclin family. (404 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
KLK3Kallikrein related peptidase 3; Belongs to the peptidase S1 family. (261 aa)
E2F3E2F transcription factor 3. (465 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
LOC457015LOW QUALITY PROTEIN: endoplasmin-like. (448 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (855 aa)
INSRRTyrosine-protein kinase receptor. (1297 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREBBPCREB binding protein. (2442 aa)
LOC100610002IKBKG isoform 9. (401 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CREB5CREB5 isoform 1. (508 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
ERGV-ets erythroblastosis virus E26 oncogene homolog (Avian). (486 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
TCF7Transcription factor 7. (481 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CCNE1CCNE1 isoform 1; Belongs to the cyclin family. (411 aa)
LOC107968084Heat shock protein HSP 90-beta-like. (361 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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