STRINGSTRING
E2F2 E2F2 NRAS NRAS TGFB2 TGFB2 CTBP2 CTBP2 HRAS HRAS DDB2 DDB2 CBL CBL CDKN1B CDKN1B RB1 RB1 NFKBIA NFKBIA TGFB3 TGFB3 SHC4 SHC4 TP53 TP53 GRB2 GRB2 SMAD4 SMAD4 MAP2K2 MAP2K2 PIK3R2 PIK3R2 TGFB1 TGFB1 BCL2L1 BCL2L1 E2F1 E2F1 MAPK1 MAPK1 PIK3CB PIK3CB NFKB1 NFKB1 CDK6 CDK6 IKBKB IKBKB GADD45G GADD45G BCR BCR CDK4 CDK4 SOS2 SOS2 GAB2 GAB2 CRKL CRKL HDAC2 HDAC2 BAK1 BAK1 SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 RELA RELA CDKN1A CDKN1A PTPN11 PTPN11 MAP2K1 MAP2K1 SHC3 SHC3 PIK3R3 PIK3R3 E2F3 E2F3 MECOM MECOM GADD45B GADD45B ABL1 ABL1 TGFBR1 TGFBR1 MYC MYC HDAC1 HDAC1 LOC100610002 LOC100610002 PIK3R1 PIK3R1 CTBP1 CTBP1 BRAF BRAF AKT1 AKT1 CRK CRK ARAF ARAF CHUK CHUK KRAS KRAS POLK POLK AKT3 AKT3 CCND1 CCND1 AKT2 AKT2 BAX BAX RUNX1 RUNX1 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F2E2F transcription factor 2. (437 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CTBP2CTBP2 isoform 10. (985 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
DDB2Damage-specific DNA binding protein 2, 48kDa. (427 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
RB1RB transcriptional corepressor 1. (928 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SHC4SHC adaptor protein 4. (630 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
E2F1E2F transcription factor 1. (437 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa)
GADD45GGrowth arrest and DNA-damage-inducible, gamma. (159 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
E2F3E2F transcription factor 3. (465 aa)
MECOMMDS1 and EVI1 complex locus. (1230 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (160 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
LOC100610002IKBKG isoform 9. (401 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
POLKPolymerase (DNA directed) kappa. (897 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BAXBAX isoform 7. (123 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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