STRINGSTRING
E2F2 E2F2 NRAS NRAS HRAS HRAS DDB2 DDB2 RB1 RB1 PRKCB PRKCB TP53 TP53 PRKCA PRKCA GRB2 GRB2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 PRKCG PRKCG ALK ALK E2F1 E2F1 PLCG1 PLCG1 MAPK1 MAPK1 FHIT FHIT PIK3CB PIK3CB EGF EGF RXRB RXRB CDK6 CDK6 GADD45G GADD45G CDK4 CDK4 RASSF1 RASSF1 SOS2 SOS2 RXRA RXRA FOXO3 FOXO3 BAK1 BAK1 RASSF5 RASSF5 SOS1 SOS1 MAPK3 MAPK3 CDKN1A CDKN1A STK4 STK4 MAP2K1 MAP2K1 PIK3R3 PIK3R3 E2F3 E2F3 EGFR EGFR ERBB2 ERBB2 GADD45B GADD45B HGF HGF PLCG2 PLCG2 PIK3R1 PIK3R1 BRAF BRAF RXRG RXRG AKT1 AKT1 RARB RARB MET MET ARAF ARAF EML4 EML4 KRAS KRAS POLK POLK AKT3 AKT3 CCND1 CCND1 CASP9 CASP9 AKT2 AKT2 STAT3 STAT3 BAX BAX BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F2E2F transcription factor 2. (437 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
DDB2Damage-specific DNA binding protein 2, 48kDa. (427 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
E2F1E2F transcription factor 1. (437 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FHITBis(5'-adenosyl)-triphosphatase. (147 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
RXRBRetinoid X receptor, beta. (537 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45GGrowth arrest and DNA-damage-inducible, gamma. (159 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RASSF1Ras association (RalGDS/AF-6) domain family member 1. (340 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RXRARetinoid X receptor, alpha. (462 aa)
FOXO3FOXO3 isoform 1. (673 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
RASSF5Ras association (RalGDS/AF-6) domain family member 5. (418 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
E2F3E2F transcription factor 3. (465 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (160 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
RXRGRetinoid X receptor gamma. (473 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
RARBRetinoic acid receptor, beta. (448 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
EML4EML4 isoform 5. (992 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
POLKPolymerase (DNA directed) kappa. (897 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
BAXBAX isoform 7. (123 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.