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| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (233 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | DDB2 | Damage-specific DNA binding protein 2, 48kDa. (427 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | FZD4 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa) |
| | PGR | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (933 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | BRCA2 | Breast cancer 2, early onset. (3418 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | ESR2 | Estrogen receptor 2. (530 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1364 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | FZD2 | FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | AXIN2 | AXIN2 isoform 1. (843 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | NOTCH3 | NOTCH3 isoform 1. (2321 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1441 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1426 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (716 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa) |
| | APC | Adenomatous polyposis coli protein isoform X10. (2844 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | HEY2 | Hairy/enhancer-of-split related with YRPW motif 2. (337 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa) |
| | CDK6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | GADD45G | Growth arrest and DNA-damage-inducible, gamma. (159 aa) |
| | NOTCH1 | NOTCH1 isoform 1. (2555 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | FZD6 | Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | CTNNB1 | Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | BAK1 | BCL2-antagonist/killer 1. (211 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | SHC1 | SHC (Src homology 2 domain containing) transforming protein 1. (584 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa) |
| | NOTCH4 | NOTCH4 isoform 3. (2006 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) |
| | CSNK1A1L | Casein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | SHC3 | SHC3 isoform 2. (598 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | DLL3 | Delta like canonical Notch ligand 3. (618 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | WNT7A | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa) |
| | CSNK1A1 | Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (854 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (900 aa) |
| | E2F3 | E2F transcription factor 3. (465 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa) |
| | IGF1 | Insulin-like growth factor 1 (Somatomedin C). (196 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (304 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa) |
| | GADD45B | Growth arrest and DNA-damage-inducible, beta. (160 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | NOTCH2 | NOTCH2 isoform 1. (2612 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | BRAF | BRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | FRAT1 | FRAT regulator of WNT signaling pathway 1. (279 aa) |
| | TCF7 | Transcription factor 7. (481 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | ARAF | V-raf murine sarcoma 3611 viral oncogene homolog. (606 aa) |
| | KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | POLK | Polymerase (DNA directed) kappa. (897 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | FZD1 | FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa) |
| | APC2 | APC2 isoform 1. (2301 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa) |
| | HEYL | Hes related family bHLH transcription factor with YRPW motif like. (328 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | BAX | BAX isoform 7. (123 aa) |
