STRINGSTRING
MTOR MTOR WASF2 WASF2 ENSPTRP00000000715 ENSPTRP00000000715 NRAS NRAS PLA2G4A PLA2G4A HRAS HRAS DGKZ DGKZ RPS6KB2 RPS6KB2 SP1 SP1 CHPT1 CHPT1 HIF1A HIF1A PLA2G4E PLA2G4E PLA2G4D PLA2G4D PRKCB PRKCB PLD2 PLD2 DGKE DGKE RPS6KB1 RPS6KB1 PRKCA PRKCA GRB2 GRB2 PLPP2 PLPP2 PIP5K1C PIP5K1C MAP2K2 MAP2K2 PIK3R2 PIK3R2 PRKCG PRKCG SLC5A7 SLC5A7 DGKD DGKD GPCPD1 GPCPD1 PLCG1 PLCG1 MAPK1 MAPK1 PDGFB PDGFB CHKB CHKB PIK3CB PIK3CB DGKG DGKG PDGFRA PDGFRA EGF EGF PLPP1 PLPP1 SLC22A4 SLC22A4 MAPK9 MAPK9 SLC44A4 SLC44A4 SLC22A1 SLC22A1 SLC22A3 SLC22A3 RALGDS RALGDS WASF3 WASF3 MAPK8 MAPK8 SLC44A2 SLC44A2 PLD1 PLD1 SOS2 SOS2 WASF1 WASF1 SOS1 SOS1 MAPK3 MAPK3 DGKB DGKB PDGFA PDGFA LOC749464 LOC749464 LYPLA1-2 LYPLA1-2 MAP2K1 MAP2K1 TSC1 TSC1 PIK3R3 PIK3R3 SLC22A5 SLC22A5 WAS WAS SLC44A1 SLC44A1 EGFR EGFR MAPK10 MAPK10 PIP5K1B PIP5K1B SLC44A3 SLC44A3 PIP5K1A PIP5K1A PIK3R1 PIK3R1 SLC22A2 SLC22A2 DGKH DGKH DGKK DGKK PDGFD PDGFD FOS FOS PLPP3 PLPP3 PDGFRB PDGFRB DGKQ DGKQ AKT1 AKT1 PCYT1B PCYT1B SLC44A5 SLC44A5 KRAS KRAS AKT3 AKT3 RHEB RHEB DGKA DGKA AKT2 AKT2 PLA2G4F PLA2G4F PDGFC PDGFC CHKA CHKA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
WASF2WAS protein family, member 2. (498 aa)
ENSPTRP00000000715Wiskott-Aldrich syndrome protein family member 2-like. (492 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
PLA2G4APhospholipase A2. (749 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
DGKZDiacylglycerol kinase. (1117 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
SP1Sp1 transcription factor. (786 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (406 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PLA2G4EPhospholipase A2. (868 aa)
PLA2G4DPhospholipase A2. (818 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLD2Phospholipase. (933 aa)
DGKEDiacylglycerol kinase. (567 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PLPP2PLPP2 isoform 5. (309 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
DGKDDiacylglycerol kinase. (1254 aa)
GPCPD1Glycerophosphocholine phosphodiesterase GDE1 homolog. (672 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CHKBCHKB-CPT1B isoform 3. (395 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
DGKGDiacylglycerol kinase. (791 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
SLC22A4Solute carrier family 22 member 4. (551 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (710 aa)
SLC22A1SLC22A1 isoform 2. (552 aa)
SLC22A3Solute carrier family 22 member 3. (556 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (914 aa)
WASF3WH2 domain-containing protein. (502 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (727 aa)
PLD1Phospholipase. (1074 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
DGKBDiacylglycerol kinase. (803 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
LOC749464Phospholipase A2. (781 aa)
LYPLA1-2Lysophospholipase 1. (58 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
TSC1TSC complex subunit 1. (1164 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
SLC22A5Solute carrier family 22 member 5. (581 aa)
WASWAS isoform 1. (502 aa)
SLC44A1SLC44A1 isoform 3; Belongs to the CTL (choline transporter-like) family. (720 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (575 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (653 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
SLC22A2Solute carrier family 22 member 2. (555 aa)
DGKHDiacylglycerol kinase. (1220 aa)
DGKKDiacylglycerol kinase. (1283 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PLPP3T0036865 isoform 1. (342 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
DGKQDiacylglycerol kinase. (952 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (719 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RHEBRHEB isoform 1. (184 aa)
DGKADiacylglycerol kinase. (746 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLA2G4FPhospholipase A2. (849 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CHKACholine kinase alpha. (455 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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