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| | ARF1 | ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa) |
| | PRDX6 | Peroxiredoxin 6. (225 aa) |
| | PEA15 | Astrocytic phosphoprotein PEA-15; Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A- mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). (130 aa) |
| | CRABP2 | Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa) |
| | ENSPPYP00000000957 | annotation not available (292 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa) |
| | DKFZp469I0118 | HNRNPA3 isoform 2. (308 aa) |
| | ENSPPYP00000001288 | annotation not available (268 aa) |
| | DDAH1 | Dimethylarginine dimethylaminohydrolase 1. (285 aa) |
| | CR201_G0017202 | HNRNPA3 isoform 4. (248 aa) |
| | FUBP1 | FUBP1 isoform 8. (662 aa) |
| | PRDX1 | PRDX1 isoform 2. (199 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (368 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (707 aa) |
| | FABP3 | Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (149 aa) |
| | CDC42 | Cell division cycle 42. (191 aa) |
| | ENSPPYP00000002069 | 40S ribosomal protein SA-like. (289 aa) |
| | SLC25A33 | SLC25A33 isoform 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa) |
| | ENO1 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production; Belongs to the enolase family. (434 aa) |
| | PARK7 | PARK7 isoform 1. (189 aa) |
| | ENSPPYP00000002410 | annotation not available (99 aa) |
| | ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6; Belongs to the glycosyltransferase 29 family. (398 aa) |
| | CR201_G0028223 | YWHAZ isoform 22. (245 aa) |
| | ENSPPYP00000002695 | annotation not available (291 aa) |
| | VCL | VCL isoform 2. (1134 aa) |
| | PGAM1 | Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. (254 aa) |
| | NT5C2 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). Belongs to the 5'(3')-deoxyribonucleotidase family. (561 aa) |
| | PRDX3 | Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (256 aa) |
| | MGMT | MGMT isoform 1. (238 aa) |
| | ENSPPYP00000003305 | annotation not available (159 aa) |
| | GSTP1 | Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (323 aa) |
| | CFL1 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. (165 aa) |
| | STIP1 | STIP1 isoform 2. (543 aa) |
| | UBXN1 | UBXN1 isoform 1. (296 aa) |
| | ENSPPYP00000003884 | annotation not available (256 aa) |
| | PSMA1 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa) |
| | TRIM66 | TRIM66 isoform 4. (848 aa) |
| | ENSPPYP00000004148 | annotation not available (164 aa) |
| | P2RY2 | Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa) |
| | P2RY6 | P2RY6 isoform 1. (328 aa) |
| | ENSPPYP00000004309 | annotation not available (437 aa) |
| | LOC100455442 | Heterogeneous nuclear ribonucleoprotein A1-like. (320 aa) |
| | APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (219 aa) |
| | HYOU1 | Hypoxia up-regulated 1. (999 aa) |
| | HSPA8 | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (646 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (335 aa) |
| | TPI1 | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (362 aa) |
| | ENSPPYP00000004797 | annotation not available (276 aa) |
| | PCBP2 | Poly(rC) binding protein 2. (362 aa) |
| | CBX5 | CBX5 isoform 2. (191 aa) |
| | ENSPPYP00000005310 | annotation not available (135 aa) |
| | ATP5F1B | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (523 aa) |
| | DCTN2 | DCTN2 isoform 1. (401 aa) |
| | ENSPPYP00000005404 | annotation not available (374 aa) |
| | CCT2 | Chaperonin containing TCP1 subunit 2. (535 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | ENSPPYP00000005659 | annotation not available (212 aa) |
| | PEBP1 | Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family. (267 aa) |
| | RPLP0 | 60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa) |
| | UBC | UBC isoform 2. (625 aa) |
| | HSPH1 | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. (851 aa) |
| | TPT1 | TPT1 isoform 1; Belongs to the TCTP family. (172 aa) |
| | ENSPPYP00000006146 | annotation not available (173 aa) |
| | HNRNPC | Heterogeneous nuclear ribonucleoprotein C; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilit [...] (306 aa) |
| | LOC100446892 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | GPR68 | GPR68 isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa) |
| | HSP90AA1 | HSP90AA1 isoform 6. (615 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | TJP1 | TJP1 isoform 1; Belongs to the MAGUK family. (1746 aa) |
| | ENSPPYP00000007167 | annotation not available (216 aa) |
| | PDIA3 | Protein disulfide-isomerase A3. (466 aa) |
| | ENSPPYP00000007358 | annotation not available (297 aa) |
| | PPIB | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa) |
| | ETFA | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. (333 aa) |
| | CR201_G0003353 | RPS27A isoform 1. (155 aa) |
| | ENSPPYP00000007710 | annotation not available (291 aa) |
| | FUS | FUS isoform 1. (492 aa) |
| | TUBB3 | T0170152 isoform 1; Belongs to the tubulin family. (450 aa) |
| | EIF5A | Eukaryotic translation initiation factor 5A. (167 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ENSPPYP00000009291 | annotation not available (118 aa) |
| | MAPT | Microtubule-associated protein. (759 aa) |
| | GFAP | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. (431 aa) |
| | BPTF | BPTF isoform 5. (2811 aa) |
| | ATP5PD | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa) |
| | GRB2 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa) |
| | P4HB | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (508 aa) |
| | CBX1 | CBX1 isoform 1. (185 aa) |
| | PHB | Prohibitin. (272 aa) |
| | TTR | Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (147 aa) |
| | ATP5F1A | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (553 aa) |
| | ENSPPYP00000010292 | annotation not available (287 aa) |
| | ENSPPYP00000010418 | annotation not available (466 aa) |
| | NRTN | NRTN isoform 1. (197 aa) |
| | KHSRP | KHSRP isoform 3. (637 aa) |
| | CALR | Calreticulin. (417 aa) |
| | TPM4 | TPM4 isoform 4; Belongs to the tropomyosin family. (260 aa) |
| | ENSPPYP00000010984 | annotation not available (156 aa) |
| | HNRNPL | LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein L. (588 aa) |
| | CKM | CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. (360 aa) |
| | ENSPPYP00000011654 | annotation not available (312 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | ENSPPYP00000012441 | annotation not available (287 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (130 aa) |
| | CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa) |
| | CR201_G0024709 | LGALS1 isoform 5. (77 aa) |
| | ST13 | Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). (369 aa) |
| | ACO2 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa) |
| | NT5DC4 | NT5DC4 isoform 1. (420 aa) |
| | CR201_G0049473 | MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (600 aa) |
| | TACR1 | Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa) |
| | PCBP1 | Poly(rC) binding protein 1. (356 aa) |
| | MYCN | MYCN proto-oncogene, bHLH transcription factor. (464 aa) |
| | ENSPPYP00000014113 | annotation not available (353 aa) |
| | HSPD1 | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa) |
| | ENSPPYP00000014644 | annotation not available (149 aa) |
| | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa) |
| | CR201_G0032388 | Hexosyltransferase. (562 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | ENSPPYP00000015165 | annotation not available (280 aa) |
| | CR201_G0027927 | HNRNPA1 isoform 8. (295 aa) |
| | ENSPPYP00000015204 | annotation not available (324 aa) |
| | ENSPPYP00000015235 | annotation not available (464 aa) |
| | UQCRC1 | Ubiquinol-cytochrome c reductase core protein 1. (480 aa) |
| | CR201_G0006390 | RPSA isoform 5; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits; Belongs to the universal ribosomal protein uS2 family. (383 aa) |
| | TF | TF isoform 1; Belongs to the transferrin family. (703 aa) |
| | LOC112132763 | Peptidyl-prolyl cis-trans isomerase A (cyclophilin A). (167 aa) |
| | B3GNT5 | Hexosyltransferase. (378 aa) |
| | FAM131A | FAM131A isoform 8. (281 aa) |
| | ENSPPYP00000016161 | annotation not available (290 aa) |
| | UCHL1 | Ubiquitin carboxyl-terminal hydrolase. (223 aa) |
| | ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa) |
| | ENSPPYP00000016598 | annotation not available (104 aa) |
| | HNRNPDL | Heterogeneous nuclear ribonucleoprotein D like. (420 aa) |
| | SNCA | Alpha-synuclein; May be involved in the regulation of dopamine release and transport; Belongs to the synuclein family. (140 aa) |
| | CR201_G0000077 | IQCM isoform 3. (199 aa) |
| | CERCAM | CERCAM isoform 3. (528 aa) |
| | TUBA1B | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa) |
| | SRSF1 | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...] (253 aa) |
| | ALDOA | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. (364 aa) |
| | LMNB2 | LMNB2 isoform 2; Belongs to the intermediate filament family. (577 aa) |
| | ENSPPYP00000024257 | LOW QUALITY PROTEIN: stress-70 protein, mitochondrial-like. (403 aa) |
| | RSU1 | Ras suppressor protein 1. (277 aa) |
| | RAB42 | RAB42 isoform 2. (218 aa) |
| | PRDX2 | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (198 aa) |
| | PPA1 | Inorganic pyrophosphatase. (244 aa) |
| | CRMP1 | CRMP1 isoform 2. (405 aa) |
| | ENSPPYP00000023562 | annotation not available (156 aa) |
| | ENSPPYP00000023500 | annotation not available (140 aa) |
| | PA2G4 | T0096427 isoform 1. (394 aa) |
| | UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) |
| | RPSA | 40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa) |
| | TMEM31 | TMEM31 isoform 1. (205 aa) |
| | HNRNPH2 | Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity). (449 aa) |
| | PGK1 | Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa) |
| | ENSPPYP00000022918 | annotation not available (235 aa) |
| | NONO | Non-POU domain-containing octamer-binding protein; DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclea [...] (471 aa) |
| | PRDX4 | PRDX4 isoform 1. (271 aa) |
| | ENSPPYP00000022466 | annotation not available (172 aa) |
| | FUBP3 | Far upstream element binding protein 3. (572 aa) |
| | SPTAN1 | SPTAN1 isoform 10. (2538 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa) |
| | ENSPPYP00000020184 | annotation not available (107 aa) |
| | PSMC2 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa) |
| | CR201_G0027927-2 | HNRNPA1 isoform 5. (268 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and he [...] (353 aa) |
| | ENSPPYP00000019835 | annotation not available (258 aa) |
| | ENSPPYP00000019828 | annotation not available (154 aa) |
| | CPVL | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. (476 aa) |
| | CR201_G0040641 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (143 aa) |
| | PPIA | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (306 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | YWHAG | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. (247 aa) |
| | FSCN1 | FSCN1 isoform 3. (444 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | EZR | EZR isoform 1. (586 aa) |
| | FABP7 | FABP7 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | DDO | D-aspartate oxidase. (369 aa) |
| | BEND3 | BEND3 isoform 1. (825 aa) |
| | CEP162 | CEP162 isoform 2. (1235 aa) |
| | SCUBE3 | SCUBE3 isoform 1. (897 aa) |
| | HSPA1A | Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (641 aa) |
| | LOC100439093 | Peptidyl-prolyl cis-trans isomerase A (cyclophilin A). (168 aa) |
| | TUBB | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (444 aa) |
| | HNRNPH1 | HNRNPH1 isoform 9. (448 aa) |
| | DBN1 | DBN1 isoform 4. (632 aa) |
| | NSD1 | NSD1 isoform 2. (2427 aa) |
| | SNCB | Beta-synuclein; Belongs to the synuclein family. (134 aa) |
| | LOC100442029 | Inorganic pyrophosphatase; Belongs to the PPase family. (292 aa) |
| | GRPEL2 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). (225 aa) |
| | PFDN1 | Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family. (127 aa) |
| | HSPA9 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. (679 aa) |
| | VDAC1 | VDAC1 isoform 1. (232 aa) |
| | HSPA4 | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. (575 aa) |
| | ENSPPYP00000017597 | annotation not available (424 aa) |
| | LMNB1 | LMNB1 isoform 1; Belongs to the intermediate filament family. (586 aa) |
| | CR201_G0016076 | MAP1B isoform 1. (1431 aa) |
| | OCLN | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. (522 aa) |
| | OXCT1 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (520 aa) |
| | GDNF | GDNF isoform 6. (185 aa) |
| | ENSPPYP00000017062 | annotation not available (62 aa) |
| | ENSPPYP00000017056 | annotation not available (412 aa) |
| | LOC100447051 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa) |
| | CASP3 | CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa) |
| | ENSPPYP00000016983 | annotation not available (185 aa) |
| | ENSPPYP00000016980 | annotation not available (100 aa) |
| | FGB | FGB isoform 1. (491 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa) |
| | TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (220 aa) |
| | PTCH1 | PTCH1 isoform 7. (1429 aa) |
| | WNK2 | WNK2 isoform 7. (2270 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (464 aa) |
| | UBQLN1 | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] (577 aa) |
| | ENSPPYP00000021481 | annotation not available (599 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase isoform X1. (806 aa) |
| | NDRG1 | NDRG1 isoform 2. (408 aa) |
| | YWHAZ | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity); Belongs to the 14-3-3 family. (245 aa) |
| | ENSPPYP00000020985 | annotation not available (197 aa) |
| | FABP5 | FABP5 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa) |
| | DPYSL2 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (572 aa) |
| | NEFL | Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. (543 aa) |
| | CR201_G0005182 | NEFM isoform 1; Belongs to the intermediate filament family. (841 aa) |
