STRINGSTRING
IARS2 IARS2 EPRS1 EPRS1 TARS2 TARS2 WARS2 WARS2 PARS2 PARS2 YARS1 YARS1 CARS1 CARS1 TMEM179B TMEM179B MARS1 MARS1 CARS2 CARS2 WARS1 WARS1 TARS3 TARS3 AARS1 AARS1 KARS1 KARS1 DARS1 DARS1 MARS2 MARS2 QARS1 QARS1 LARS2 LARS2 AIMP1 AIMP1 TARS1 TARS1 HARS2 HARS2 LARS1 LARS1 RARS1 RARS1 EEF1E1 EEF1E1 VARS2 VARS2 AARS2 AARS2 RARS2 RARS2 AIMP2 AIMP2 GARS1 GARS1 IARS1 IARS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IARS2IARS2 isoform 1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1012 aa)
EPRS1EPRS isoform 1. (1416 aa)
TARS2TARS2 isoform 3. (718 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
PARS2Probable proline--tRNA ligase, mitochondrial. (267 aa)
YARS1Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. (530 aa)
CARS1Cysteinyl-tRNA synthetase. (831 aa)
TMEM179BTransmembrane protein 179B. (219 aa)
MARS1Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (900 aa)
CARS2CARS2 isoform 10. (560 aa)
WARS1Tryptophan--tRNA ligase, cytoplasmic; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). (473 aa)
TARS3TARSL2 isoform 1. (707 aa)
AARS1Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (954 aa)
KARS1Lysine--tRNA ligase. (625 aa)
DARS1Aspartate--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (485 aa)
MARS2Methionyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (593 aa)
QARS1QARS isoform 2; Belongs to the class-I aminoacyl-tRNA synthetase family. (793 aa)
LARS2Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (903 aa)
AIMP1AIMP1 isoform 1. (303 aa)
TARS1TARS isoform 1. (619 aa)
HARS2Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). (480 aa)
LARS1Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs; Belongs to the class-I aminoacyl-tRNA synthetase family. (1211 aa)
RARS1Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. (660 aa)
EEF1E1Eukaryotic translation elongation factor 1 epsilon-1. (160 aa)
VARS2Valyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1063 aa)
AARS2AARS2 isoform 1; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (907 aa)
RARS2Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (577 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa)
GARS1Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. (749 aa)
IARS1IARS isoform 1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1211 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.