Your Input: | |
| | EGLN1 | Egl-9 family hypoxia inducible factor 1. (426 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | ATF3 | Activating transcription factor 3. (181 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (401 aa) |
| | PTPN7 | PTPN7 isoform 3. (425 aa) |
| | RXRG | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (462 aa) |
| | DUSP12 | DUSP12 isoform 2. (353 aa) |
| | PEA15 | Astrocytic phosphoprotein PEA-15; Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A- mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). (130 aa) |
| | DUSP23 | Dual specificity phosphatase 23. (150 aa) |
| | RORC | Nuclear receptor ROR-gamma; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respective [...] (642 aa) |
| | ARNT | ARNT isoform 1. (789 aa) |
| | CIART | CIART isoform 3. (284 aa) |
| | SLC16A4 | SLC16A4 isoform 3. (452 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | JUN | JUN isoform 1; Belongs to the bZIP family. (334 aa) |
| | MAP3K6 | MAP3K6 isoform 1. (1288 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (735 aa) |
| | PER3 | PER3 isoform 5. (1166 aa) |
| | CREM | cAMP responsive element modulator. (299 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | EGR2 | Early growth response 2. (476 aa) |
| | HIF1AN | Hypoxia inducible factor 1 subunit alpha inhibitor. (349 aa) |
| | PITX3 | Homeobox protein. (302 aa) |
| | CR201_G0045868 | DUSP8 isoform 1. (374 aa) |
| | NPAS4 | Neuronal PAS domain protein 4. (802 aa) |
| | FOSL1 | FOSL1 isoform 2. (270 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (447 aa) |
| | CRY2 | Cryptochrome circadian regulator 2. (593 aa) |
| | ARNTL | Aryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] (583 aa) |
| | PGR | PGR isoform 1. (935 aa) |
| | HSPB2 | HSPB2-C11orf52 isoform 2; Belongs to the small heat shock protein (HSP20) family. (182 aa) |
| | DUSP16 | DUSP16 isoform 2. (488 aa) |
| | BHLHE41 | BHLHE41 isoform 1. (265 aa) |
| | ARNTL2 | Aryl hydrocarbon receptor nuclear translocator like 2. (636 aa) |
| | ATF1 | ATF1 isoform 1. (223 aa) |
| | RARG | RARG isoform 5. (469 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family (By similarity). (491 aa) |
| | ENSPPYP00000005310 | annotation not available (135 aa) |
| | NAB2 | NGFI-A binding protein 2. (525 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) |
| | CR201_G0014033 | PTPRR isoform 6. (530 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | CRY1 | Cryptochrome circadian regulator 1. (586 aa) |
| | MAPKAPK5 | MAPKAPK5 isoform 3. (467 aa) |
| | NCOR2 | NCOR2 isoform 6. (2461 aa) |
| | CR201_G0041110 | DUSP16 isoform 1. (140 aa) |
| | FBXL3 | F-box and leucine rich repeat protein 3. (428 aa) |
| | CEBPE | CCAAT/enhancer-binding protein. (281 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa) |
| | EGLN3 | EGLN3 isoform 1. (239 aa) |
| | STYX | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (223 aa) |
| | CR201_G0009767 | HIF1A isoform 5. (735 aa) |
| | ESR2 | ESR2 isoform 12. (531 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | JDP2 | JDP2 isoform 3. (238 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional act [...] (896 aa) |
| | MAPK6 | Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase s [...] (673 aa) |
| | RORA | RORA isoform 12. (555 aa) |
| | CA12 | CA12 isoform 1; Belongs to the alpha-carbonic anhydrase family. (354 aa) |
| | CRABP1 | Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa) |
| | ARNT2 | ARNT2 isoform 3. (610 aa) |
| | CREBBP | CREBBP isoform 1. (2328 aa) |
| | IQCK | IQCK isoform 1. (287 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | PER1 | PER1 isoform 10. (1110 aa) |
| | NCOR1 | NCOR1 isoform 1. (2467 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | DUSP3 | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa) |
| | RARA | RARA isoform 2. (460 aa) |
| | NR1D1 | NR1D1 isoform 1. (612 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | CSNK1D | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] (404 aa) |
| | MAPK4 | MAPK4 isoform 1. (587 aa) |
| | GADD45B | GADD45B isoform 5. (148 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | IER2 | Immediate early response 2. (220 aa) |
| | CEBPG | CEBPG isoform 1. (150 aa) |
| | EGLN2 | T0155508 isoform 1. (407 aa) |
| | FOSB | FOSB isoform 8. (237 aa) |
| | HIF3A | HIF3A isoform 1. (613 aa) |
| | NPAS1 | NPAS1 isoform 1. (590 aa) |
| | VRK3 | VRK3 isoform 3. (424 aa) |
| | ZFP36 | ZFP36 isoform 1. (216 aa) |
| | DUSP15 | DUSP15 isoform 5; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (228 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1420 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (345 aa) |
| | ENSPPYP00000012589 | Putative nuclear receptor corepressor 1-like protein NCOR1P1. (101 aa) |
| | NRIP1 | NRIP1 isoform 1. (1141 aa) |
| | LOC100447547 | T0085674 isoform 1; Belongs to the protein kinase superfamily. (416 aa) |
| | ATF4 | ATF4 isoform 1. (352 aa) |
| | EP300 | EP300 isoform 1. (2380 aa) |
| | TEF | TEF transcription factor, PAR bZIP family member. (273 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (474 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (351 aa) |
| | ENSPPYP00000013364 | annotation not available (267 aa) |
| | ENSPPYP00000013398 | annotation not available (195 aa) |
| | NPAS2 | NPAS2 isoform 1. (889 aa) |
| | EPAS1 | Endothelial PAS domain protein 1. (869 aa) |
| | PRKD3 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (318 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1293 aa) |
| | TRIB2 | Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. (343 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity); Belongs to the nuclear hormone receptor family. (598 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | CREB1 | CREB1 isoform 1. (341 aa) |
| | ARL4C | ADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family. (201 aa) |
| | PER2 | PER2 isoform 2. (1226 aa) |
| | SLC49A4 | Solute carrier family 49 member 4. (478 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma. (477 aa) |
| | BHLHE40 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] (412 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa) |
| | CSRNP1 | Cysteine/serine-rich nuclear protein 1; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis (By similarity); Belongs to the AXUD1 family. (661 aa) |
| | RARB | RARB isoform 2. (526 aa) |
| | THRB | THRB isoform 4. (460 aa) |
| | NR1D2 | NR1D2 isoform 1. (504 aa) |
| | TBL1XR1 | Transducin beta like 1 X-linked receptor 1. (514 aa) |
| | CLOCK | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] (846 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (384 aa) |
| | HSPB3 | Heat shock protein family B (small) member 3; Belongs to the small heat shock protein (HSP20) family. (150 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1505 aa) |
| | ATF5 | ATF5 isoform 1. (147 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | CREBRF | CREBRF isoform 1. (639 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | IER3 | IER3 isoform 1. (166 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | NCOA7 | NCOA7 isoform 1. (900 aa) |
| | MAP3K5 | MAP3K5 isoform 1. (1327 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | MAP3K4 | MAP3K4 isoform 3. (1517 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (809 aa) |
| | RXRB | Retinoid X receptor beta. (536 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | CREB3L2 | Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] (520 aa) |
| | EGR3 | EGR3 isoform 1. (387 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa) |
| | FABP5 | FABP5 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa) |
| | FABP9 | FABP9 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | FABP4 | Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | FABP12 | FABP12 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (371 aa) |
| | CA9 | Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (465 aa) |
| | RORB | RORB isoform 1. (516 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | NFIL3 | Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa) |
| | NR4A3 | NR4A3 isoform 1. (626 aa) |
| | RXRA | RXRA isoform 2. (456 aa) |
| | ENSPPYP00000022295 | annotation not available (209 aa) |
| | TBL1X | TBL1X isoform 1. (587 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | OPHN1 | OPHN1 isoform 1. (802 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (745 aa) |
| | DUSP9 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (310 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1464 aa) |
| | RPS6KA4 | Ribosomal protein S6 kinase. (480 aa) |
| | ENSPPYP00000024510 | annotation not available (85 aa) |
| | HSPB1 | HSPB1 isoform 1; Belongs to the small heat shock protein (HSP20) family. (210 aa) |
| | NR4A1 | NR4A1 isoform 2. (611 aa) |
