STRINGSTRING
RGL1 RGL1 NRAS NRAS SHOC2 SHOC2 KRAS KRAS RASGRP1 RASGRP1 RASGRF1 RASGRF1 NF1 NF1 RALBP1 RALBP1 RRAS RRAS LOC100448582 LOC100448582 RALB RALB MRAS MRAS RASA2 RASA2 RGL2 RGL2 RALA RALA RALGDS RALGDS RRAS2 RRAS2 RASGRP2 RASGRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RGL1RGL1 isoform 1. (798 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
SHOC2Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. (582 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
RASGRP1RASGRP1 isoform 2. (787 aa)
RASGRF1RASGRF1 isoform 1. (1223 aa)
NF1NF1 isoform 6. (2838 aa)
RALBP1RalA binding protein 1. (655 aa)
RRASRRAS isoform 1. (218 aa)
LOC100448582RGL4 isoform 4. (577 aa)
RALBRas-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By s [...] (269 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
RASA2RASA2 isoform 1. (807 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (777 aa)
RALARAS like proto-oncogene A. (206 aa)
RALGDSRALGDS isoform 4. (912 aa)
RRAS2RRAS2 isoform 1. (168 aa)
RASGRP2RASGRP2 isoform 1. (302 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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