STRINGSTRING
SKI SKI CR201_G0000132 CR201_G0000132 RNF111 RNF111 SMAD6 SMAD6 SMAD3 SMAD3 ENSPPYP00000007763 ENSPPYP00000007763 SMURF2 SMURF2 SMAD2 SMAD2 SMAD7 SMAD7 SMAD4 SMAD4 ENSPPYP00000014104 ENSPPYP00000014104 SKIL SKIL ENSPPYP00000016868 ENSPPYP00000016868 SMAD1 SMAD1 SMAD9 SMAD9 SMAD5 SMAD5 SMURF1 SMURF1 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKISKI isoform 1. (406 aa)
CR201_G0000132SMAD1 isoform 8. (430 aa)
RNF111E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSPPYP00000007763annotation not available (222 aa)
SMURF2E3 ubiquitin-protein ligase. (877 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSPPYP00000014104annotation not available (161 aa)
SKILSki-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals. (675 aa)
ENSPPYP00000016868annotation not available (85 aa)
SMAD1Mothers against decapentaplegic homolog. (73 aa)
SMAD9LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 9. (47 aa)
SMAD5Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa)
SMURF1E3 ubiquitin-protein ligase. (838 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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