(5 nodes) Nucleolar exosome (RNase complex) network (Pongo abelii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EXOSC1	Exosome component 1. (195 aa)
	DIS3L	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. (1053 aa)
	EXOSC6	Exosome complex component MTR3. (271 aa)
	EXOSC7	EXOSC7 isoform 6. (441 aa)
	EXOSC9	Exosome component 9. (439 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIS3L	EXOSC1	ENSPPYP00000007457	ENSPPYP00000002937	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	Exosome component 1.	0.998
DIS3L	EXOSC6	ENSPPYP00000007457	ENSPPYP00000008518	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	Exosome complex component MTR3.	0.997
DIS3L	EXOSC7	ENSPPYP00000007457	ENSPPYP00000015600	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	EXOSC7 isoform 6.	0.998
DIS3L	EXOSC9	ENSPPYP00000007457	ENSPPYP00000016797	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	Exosome component 9.	0.998
EXOSC1	DIS3L	ENSPPYP00000002937	ENSPPYP00000007457	Exosome component 1.	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	0.998
EXOSC1	EXOSC6	ENSPPYP00000002937	ENSPPYP00000008518	Exosome component 1.	Exosome complex component MTR3.	0.999
EXOSC1	EXOSC7	ENSPPYP00000002937	ENSPPYP00000015600	Exosome component 1.	EXOSC7 isoform 6.	0.999
EXOSC1	EXOSC9	ENSPPYP00000002937	ENSPPYP00000016797	Exosome component 1.	Exosome component 9.	0.999
EXOSC6	DIS3L	ENSPPYP00000008518	ENSPPYP00000007457	Exosome complex component MTR3.	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	0.997
EXOSC6	EXOSC1	ENSPPYP00000008518	ENSPPYP00000002937	Exosome complex component MTR3.	Exosome component 1.	0.999
EXOSC6	EXOSC7	ENSPPYP00000008518	ENSPPYP00000015600	Exosome complex component MTR3.	EXOSC7 isoform 6.	0.999
EXOSC6	EXOSC9	ENSPPYP00000008518	ENSPPYP00000016797	Exosome complex component MTR3.	Exosome component 9.	0.999
EXOSC7	DIS3L	ENSPPYP00000015600	ENSPPYP00000007457	EXOSC7 isoform 6.	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	0.998
EXOSC7	EXOSC1	ENSPPYP00000015600	ENSPPYP00000002937	EXOSC7 isoform 6.	Exosome component 1.	0.999
EXOSC7	EXOSC6	ENSPPYP00000015600	ENSPPYP00000008518	EXOSC7 isoform 6.	Exosome complex component MTR3.	0.999
EXOSC7	EXOSC9	ENSPPYP00000015600	ENSPPYP00000016797	EXOSC7 isoform 6.	Exosome component 9.	0.999
EXOSC9	DIS3L	ENSPPYP00000016797	ENSPPYP00000007457	Exosome component 9.	DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	0.998
EXOSC9	EXOSC1	ENSPPYP00000016797	ENSPPYP00000002937	Exosome component 9.	Exosome component 1.	0.999
EXOSC9	EXOSC6	ENSPPYP00000016797	ENSPPYP00000008518	Exosome component 9.	Exosome complex component MTR3.	0.999
EXOSC9	EXOSC7	ENSPPYP00000016797	ENSPPYP00000015600	Exosome component 9.	EXOSC7 isoform 6.	0.999