STRINGSTRING
LEPR LEPR HCRTR1 HCRTR1 OPRD1 OPRD1 CR201_G0054735 CR201_G0054735 PMCH PMCH SSTR1 SSTR1 SSTR5 SSTR5 NPW NPW AGRP AGRP PPY PPY HCRT HCRT SSTR2 SSTR2 NPB NPB MC2R MC2R MC4R MC4R SSTR4 SSTR4 PDYN PDYN MC3R MC3R OPRL1 OPRL1 NPBWR2 NPBWR2 MRAP MRAP CR201_G0031976 CR201_G0031976 POMC POMC RPRM RPRM SST SST NPY1R NPY1R NPY5R NPY5R NPY2R NPY2R ENSPPYP00000017161 ENSPPYP00000017161 ENSPPYP00000017683 ENSPPYP00000017683 HCRTR2 HCRTR2 MRAP2 MRAP2 MCHR2 MCHR2 NPY NPY LEP LEP ENSPPYP00000020449 ENSPPYP00000020449 PNOC PNOC NPBWR1 NPBWR1 OPRK1 OPRK1 PENK PENK OXR1 OXR1 CR201_G0023677 CR201_G0023677 OPRM1 OPRM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEPRLeptin receptor. (1165 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (376 aa)
CR201_G0054735NPY4R isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
PMCHPro-melanin concentrating hormone. (165 aa)
SSTR1SSTR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (389 aa)
SSTR5SSTR5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (378 aa)
NPWNeuropeptide W. (165 aa)
AGRPAgouti related neuropeptide. (132 aa)
PPYPancreatic polypeptide. (95 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
NPBNPB isoform 2. (125 aa)
MC2RMelanocortin 2 receptor. (297 aa)
MC4RMelanocortin 4 receptor. (332 aa)
SSTR4SSTR4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
PDYNPDYN isoform 1. (254 aa)
MC3RMelanocortin 3 receptor. (323 aa)
OPRL1Opioid related nociceptin receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NPBWR2Neuropeptides B and W receptor 2; Belongs to the G-protein coupled receptor 1 family. (333 aa)
MRAPMRAP isoform 4. (101 aa)
CR201_G0031976MCHR1 isoform 3. (297 aa)
POMCPOMC isoform 1. (266 aa)
RPRMReprimo, TP53 dependent G2 arrest mediator homolog. (109 aa)
SSTSST isoform 1. (116 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
ENSPPYP00000017161annotation not available (85 aa)
ENSPPYP00000017683annotation not available (137 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa)
MRAP2MRAP2 isoform 1. (181 aa)
MCHR2Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
NPYNPY isoform 1. (97 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSPPYP00000020449annotation not available (62 aa)
PNOCPrepronociceptin. (176 aa)
NPBWR1Neuropeptides B and W receptor 1; Belongs to the G-protein coupled receptor 1 family. (328 aa)
OPRK1Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PENKPENK isoform 3. (267 aa)
OXR1Oxidation resistance 1. (874 aa)
CR201_G0023677PYY isoform 1. (70 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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