(7 nodes) Small protein activating enzyme binding, and SUMOylation of nuclear envelope proteins network (Pongo abelii)

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Your Input:
	CR201_G0007169	SUMO1 isoform 5. (143 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	UBA2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (544 aa)
	SAE1	SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. (382 aa)
	RANGAP1	RANGAP1 isoform 1. (592 aa)
	CR201_G0021362	SUMO2 isoform 4. (95 aa)
	ENSPPYP00000024386	E3 SUMO-protein ligase RanBP2. (1139 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0007169	CR201_G0021362	ENSPPYP00000000742	ENSPPYP00000020349	SUMO1 isoform 5.	SUMO2 isoform 4.	0.530
CR201_G0007169	ENSPPYP00000024386	ENSPPYP00000000742	ENSPPYP00000024386	SUMO1 isoform 5.	E3 SUMO-protein ligase RanBP2.	0.750
CR201_G0007169	RANGAP1	ENSPPYP00000000742	ENSPPYP00000013240	SUMO1 isoform 5.	RANGAP1 isoform 1.	0.905
CR201_G0007169	SAE1	ENSPPYP00000000742	ENSPPYP00000011372	SUMO1 isoform 5.	SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family.	0.914
CR201_G0007169	UBA2	ENSPPYP00000000742	ENSPPYP00000011014	SUMO1 isoform 5.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.921
CR201_G0007169	UBE2I	ENSPPYP00000000742	ENSPPYP00000007864	SUMO1 isoform 5.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.928
CR201_G0021362	CR201_G0007169	ENSPPYP00000020349	ENSPPYP00000000742	SUMO2 isoform 4.	SUMO1 isoform 5.	0.530
CR201_G0021362	ENSPPYP00000024386	ENSPPYP00000020349	ENSPPYP00000024386	SUMO2 isoform 4.	E3 SUMO-protein ligase RanBP2.	0.973
CR201_G0021362	RANGAP1	ENSPPYP00000020349	ENSPPYP00000013240	SUMO2 isoform 4.	RANGAP1 isoform 1.	0.954
CR201_G0021362	SAE1	ENSPPYP00000020349	ENSPPYP00000011372	SUMO2 isoform 4.	SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family.	0.842
CR201_G0021362	UBA2	ENSPPYP00000020349	ENSPPYP00000011014	SUMO2 isoform 4.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.966
CR201_G0021362	UBE2I	ENSPPYP00000020349	ENSPPYP00000007864	SUMO2 isoform 4.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.999
ENSPPYP00000024386	CR201_G0007169	ENSPPYP00000024386	ENSPPYP00000000742	E3 SUMO-protein ligase RanBP2.	SUMO1 isoform 5.	0.750
ENSPPYP00000024386	CR201_G0021362	ENSPPYP00000024386	ENSPPYP00000020349	E3 SUMO-protein ligase RanBP2.	SUMO2 isoform 4.	0.973
ENSPPYP00000024386	RANGAP1	ENSPPYP00000024386	ENSPPYP00000013240	E3 SUMO-protein ligase RanBP2.	RANGAP1 isoform 1.	0.999
ENSPPYP00000024386	SAE1	ENSPPYP00000024386	ENSPPYP00000011372	E3 SUMO-protein ligase RanBP2.	SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family.	0.448
ENSPPYP00000024386	UBA2	ENSPPYP00000024386	ENSPPYP00000011014	E3 SUMO-protein ligase RanBP2.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.413
ENSPPYP00000024386	UBE2I	ENSPPYP00000024386	ENSPPYP00000007864	E3 SUMO-protein ligase RanBP2.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.999
RANGAP1	CR201_G0007169	ENSPPYP00000013240	ENSPPYP00000000742	RANGAP1 isoform 1.	SUMO1 isoform 5.	0.905
RANGAP1	CR201_G0021362	ENSPPYP00000013240	ENSPPYP00000020349	RANGAP1 isoform 1.	SUMO2 isoform 4.	0.954