30 items (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CR201_G0053435	UBB isoform 1. (128 aa)
	CR201_G0053298	MIB2 isoform 16. (744 aa)
	UBE2J2	Ubiquitin conjugating enzyme E2 J2. (259 aa)
	ISG15	ISG15 ubiquitin like modifier. (165 aa)
	ZFAND4	Zinc finger AN1-type containing 4. (726 aa)
	UBE2L6	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	UBC	UBC isoform 2. (625 aa)
	CR201_G0003353	RPS27A isoform 1. (155 aa)
	TRAF7	TNF receptor associated factor 7. (670 aa)
	ENSPPYP00000008980	annotation not available (158 aa)
	UBB	UBB isoform 2. (229 aa)
	ENSPPYP00000009931	annotation not available (76 aa)
	CR201_G0012323	UBE2Z isoform 1. (215 aa)
	KATNAL2	KATNAL2 isoform 2. (466 aa)
	CDC34	CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa)
	UBA52	UBA52 isoform 10. (128 aa)
	UBL4B	UBL4B isoform 1. (174 aa)
	ENSPPYP00000012086	annotation not available (110 aa)
	TMEM189-UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
	UBE2L3	Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] (154 aa)
	BIRC6	BIRC6 isoform 1. (4803 aa)
	UBA7	UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family. (956 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	UBA6	UBA6 isoform 1. (1052 aa)
	UBD	UBD isoform 1. (165 aa)
	UBE2H	Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	UBE2R2	Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
	UBA1	UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family. (1056 aa)
	ENSPPYP00000023562	annotation not available (156 aa)
	CR201_G0020693	T0070593 isoform 1. (151 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC6	CDC34	ENSPPYP00000013966	ENSPPYP00000010414	BIRC6 isoform 1.	CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family.	0.585
BIRC6	CR201_G0003353	ENSPPYP00000013966	ENSPPYP00000007706	BIRC6 isoform 1.	RPS27A isoform 1.	0.932
BIRC6	CR201_G0020693	ENSPPYP00000013966	ENSPPYP00000024080	BIRC6 isoform 1.	T0070593 isoform 1.	0.694
BIRC6	CR201_G0053298	ENSPPYP00000013966	ENSPPYP00000002312	BIRC6 isoform 1.	MIB2 isoform 16.	0.640
BIRC6	CR201_G0053435	ENSPPYP00000013966	ENSPPYP00000002230	BIRC6 isoform 1.	UBB isoform 1.	0.955
BIRC6	ENSPPYP00000008980	ENSPPYP00000013966	ENSPPYP00000008980	BIRC6 isoform 1.	annotation not available	0.932
BIRC6	ENSPPYP00000009931	ENSPPYP00000013966	ENSPPYP00000009931	BIRC6 isoform 1.	annotation not available	0.955
BIRC6	ENSPPYP00000012086	ENSPPYP00000013966	ENSPPYP00000012086	BIRC6 isoform 1.	annotation not available	0.978
BIRC6	ENSPPYP00000023562	ENSPPYP00000013966	ENSPPYP00000023562	BIRC6 isoform 1.	annotation not available	0.932
BIRC6	ISG15	ENSPPYP00000013966	ENSPPYP00000002343	BIRC6 isoform 1.	ISG15 ubiquitin like modifier.	0.782
BIRC6	KATNAL2	ENSPPYP00000013966	ENSPPYP00000010268	BIRC6 isoform 1.	KATNAL2 isoform 2.	0.613
BIRC6	TMEM189-UBE2V1	ENSPPYP00000013966	ENSPPYP00000012429	BIRC6 isoform 1.	Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...]	0.978
BIRC6	TRAF7	ENSPPYP00000013966	ENSPPYP00000007911	BIRC6 isoform 1.	TNF receptor associated factor 7.	0.912
BIRC6	UBA1	ENSPPYP00000013966	ENSPPYP00000022706	BIRC6 isoform 1.	UBA1 isoform 1; Belongs to the ubiquitin-activating E1 family.	0.752
BIRC6	UBA52	ENSPPYP00000013966	ENSPPYP00000010917	BIRC6 isoform 1.	UBA52 isoform 10.	0.955
BIRC6	UBA6	ENSPPYP00000013966	ENSPPYP00000016457	BIRC6 isoform 1.	UBA6 isoform 1.	0.761
BIRC6	UBA7	ENSPPYP00000013966	ENSPPYP00000015508	BIRC6 isoform 1.	UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family.	0.752
BIRC6	UBB	ENSPPYP00000013966	ENSPPYP00000009014	BIRC6 isoform 1.	UBB isoform 2.	0.782
BIRC6	UBC	ENSPPYP00000013966	ENSPPYP00000005811	BIRC6 isoform 1.	UBC isoform 2.	0.782
BIRC6	UBD	ENSPPYP00000013966	ENSPPYP00000018320	BIRC6 isoform 1.	UBD isoform 1.	0.782