(7 nodes) Domain present in ubiquitin-regulatory proteins network (Pongo abelii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBXN10	UBXN10 isoform 1. (280 aa)
	UBXN1	UBXN1 isoform 1. (296 aa)
	UBXN6	UBXN6 isoform 3. (436 aa)
	NSFL1C	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (370 aa)
	UBXN2A	UBXN2A isoform 2. (261 aa)
	VCP	Transitional endoplasmic reticulum ATPase isoform X1. (806 aa)
	FAF1	Fas associated factor 1. (650 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAF1	NSFL1C	ENSPPYP00000024718	ENSPPYP00000012121	Fas associated factor 1.	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	0.990
FAF1	UBXN1	ENSPPYP00000024718	ENSPPYP00000003643	Fas associated factor 1.	UBXN1 isoform 1.	0.995
FAF1	UBXN2A	ENSPPYP00000024718	ENSPPYP00000014077	Fas associated factor 1.	UBXN2A isoform 2.	0.463
FAF1	UBXN6	ENSPPYP00000024718	ENSPPYP00000010548	Fas associated factor 1.	UBXN6 isoform 3.	0.991
FAF1	VCP	ENSPPYP00000024718	ENSPPYP00000021408	Fas associated factor 1.	Transitional endoplasmic reticulum ATPase isoform X1.	0.999
NSFL1C	FAF1	ENSPPYP00000012121	ENSPPYP00000024718	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	Fas associated factor 1.	0.990
NSFL1C	UBXN1	ENSPPYP00000012121	ENSPPYP00000003643	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	UBXN1 isoform 1.	0.944
NSFL1C	UBXN10	ENSPPYP00000012121	ENSPPYP00000002058	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	UBXN10 isoform 1.	0.990
NSFL1C	UBXN2A	ENSPPYP00000012121	ENSPPYP00000014077	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	UBXN2A isoform 2.	0.998
NSFL1C	UBXN6	ENSPPYP00000012121	ENSPPYP00000010548	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	UBXN6 isoform 3.	0.999
NSFL1C	VCP	ENSPPYP00000012121	ENSPPYP00000021408	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	Transitional endoplasmic reticulum ATPase isoform X1.	0.999
UBXN1	FAF1	ENSPPYP00000003643	ENSPPYP00000024718	UBXN1 isoform 1.	Fas associated factor 1.	0.995
UBXN1	NSFL1C	ENSPPYP00000003643	ENSPPYP00000012121	UBXN1 isoform 1.	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	0.944
UBXN1	UBXN2A	ENSPPYP00000003643	ENSPPYP00000014077	UBXN1 isoform 1.	UBXN2A isoform 2.	0.945
UBXN1	UBXN6	ENSPPYP00000003643	ENSPPYP00000010548	UBXN1 isoform 1.	UBXN6 isoform 3.	0.958
UBXN1	VCP	ENSPPYP00000003643	ENSPPYP00000021408	UBXN1 isoform 1.	Transitional endoplasmic reticulum ATPase isoform X1.	0.999
UBXN10	NSFL1C	ENSPPYP00000002058	ENSPPYP00000012121	UBXN10 isoform 1.	NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family.	0.990
UBXN10	UBXN2A	ENSPPYP00000002058	ENSPPYP00000014077	UBXN10 isoform 1.	UBXN2A isoform 2.	0.991
UBXN10	UBXN6	ENSPPYP00000002058	ENSPPYP00000010548	UBXN10 isoform 1.	UBXN6 isoform 3.	0.991
UBXN10	VCP	ENSPPYP00000002058	ENSPPYP00000021408	UBXN10 isoform 1.	Transitional endoplasmic reticulum ATPase isoform X1.	0.989