Your Input: | |
| | ENSPPYP00000012057 | annotation not available (147 aa) |
| | UBOX5 | UBOX5 isoform 2. (512 aa) |
| | RBCK1 | RBCK1 isoform 5. (509 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (572 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) |
| | UBE2A | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | ENSPPYP00000022962 | annotation not available (77 aa) |
| | ENSPPYP00000022930 | annotation not available (282 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1755 aa) |
| | HUWE1 | HUWE1 isoform 1. (4373 aa) |
| | HDAC6 | HDAC6 isoform 2. (1208 aa) |
| | CR201_G0022864 | MKRN1 isoform 4. (480 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | LRSAM1 | LRSAM1 isoform 1. (689 aa) |
| | RC3H2 | RC3H2 isoform 1. (1143 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | TRIM32 | Tripartite motif containing 32. (653 aa) |
| | CDC26 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] (85 aa) |
| | RNF20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa) |
| | TRIM14 | Tripartite motif containing 14. (442 aa) |
| | CR201_G0001895 | CDKN2A isoform 2. (173 aa) |
| | UBE2R2 | Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa) |
| | SHARPIN | SHARPIN isoform 2. (410 aa) |
| | UBR5 | UBR5 isoform 1. (2695 aa) |
| | WWP1 | E3 ubiquitin-protein ligase. (773 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | UBE3C | UBE3C isoform 2. (1080 aa) |
| | CUL1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa) |
| | MKRN1 | Makorin ring finger protein 1. (418 aa) |
| | UBE2H | Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | HECW1 | HECW1 isoform 1. (1608 aa) |
| | TRIM56 | TRIM56 isoform 1. (755 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (838 aa) |
| | RNF216 | Ring finger protein 216. (866 aa) |
| | CR201_G0036895 | PRKN isoform 8. (335 aa) |
| | SASH1 | SASH1 isoform 2. (1192 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1683 aa) |
| | TNFAIP3 | TNFAIP3 isoform 1. (790 aa) |
| | RNF146 | E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (355 aa) |
| | CR201_G0047659 | RBR-type E3 ubiquitin transferase. (219 aa) |
| | HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (909 aa) |
| | UBE2J1 | Ubiquitin conjugating enzyme E2 J1. (318 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (462 aa) |
| | RNF5 | Ring finger protein 5. (180 aa) |
| | TRIM38 | Tripartite motif containing 38. (465 aa) |
| | RNF144B | RBR-type E3 ubiquitin transferase. (303 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | FBXO38 | FBXO38 isoform 1. (1188 aa) |
| | RNF14 | RBR-type E3 ubiquitin transferase. (474 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | KLHL3 | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). (587 aa) |
| | JADE2 | JADE2 isoform 7. (919 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | FBXL17 | FBXL17 isoform 1. (751 aa) |
| | RNF180 | E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. (579 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (849 aa) |
| | FBXO4 | FBXO4 isoform 2. (387 aa) |
| | SKP2 | SKP2 isoform 1. (410 aa) |
| | FBXL7 | F-box and leucine rich repeat protein 7. (444 aa) |
| | MARCHF6 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. (910 aa) |
| | UBE2QL1 | UBE2QL1 isoform 1. (161 aa) |
| | CR201_G0045132 | TRIML1 isoform 1. (373 aa) |
| | CR201_G0045128 | TRIML2 isoform 1. (346 aa) |
| | ENSPPYP00000016962 | annotation not available (353 aa) |
| | MARCHF1 | MARCH1 isoform 2. (542 aa) |
| | TRIM2 | Tripartite motif containing 2. (744 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (161 aa) |
| | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | ZCCHC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (1106 aa) |
| | TMEM129 | Transmembrane protein 129. (362 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | ANAPC13 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC13 family. (74 aa) |
| | UBE2E2 | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | UBE2E1 | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa) |
| | TRIM71 | TRIM71 isoform 1. (867 aa) |
| | CTNNB1 | CTNNB1 isoform 2. (781 aa) |
| | ARIH2 | RBR-type E3 ubiquitin transferase. (456 aa) |
| | DZIP3 | DZIP3 isoform 1. (1176 aa) |
| | DTX3L | DTX3L isoform 1. (708 aa) |
| | MKRN2 | Makorin ring finger protein 2. (416 aa) |
| | ZSWIM2 | ZSWIM2 isoform 2. (593 aa) |
| | TRIP12 | TRIP12 isoform 4. (2039 aa) |
| | DAW1 | Dynein assembly factor with WD repeats 1. (415 aa) |
| | CUL3 | CUL3 isoform 1; Belongs to the cullin family. (768 aa) |
| | BARD1 | BARD1 isoform 3. (777 aa) |
| | UBE2E3 | Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa) |
| | NMI | NMI isoform 1. (307 aa) |
| | ANKRD39 | ANKRD39 isoform 1. (155 aa) |
| | RNF144A | RBR-type E3 ubiquitin transferase. (292 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | RMND5A | Required for meiotic nuclear division 5 homolog A. (391 aa) |
| | ANAPC1 | ANAPC1 isoform 2. (1855 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | RNF185 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...] (192 aa) |
| | WSB1 | WSB1 isoform 2. (421 aa) |
| | BLMH | Bleomycin hydrolase; Belongs to the peptidase C1 family. (455 aa) |
| | RNF135 | Ring finger protein 135. (432 aa) |
| | ENSPPYP00000009265 | annotation not available (102 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1863 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (877 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1293 aa) |
| | RNF213 | RNF213 isoform 1. (4365 aa) |
| | NPEPPS | Aminopeptidase. (921 aa) |
| | SPOP | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] (374 aa) |
| | CDC27 | CDC27 isoform 1. (824 aa) |
| | RNF125 | RNF125 isoform 1. (196 aa) |
| | RNF165 | RNF165 isoform 2. (186 aa) |
| | RNF152 | Ring finger protein 152. (203 aa) |
| | BCL2 | BCL2 isoform 1. (238 aa) |
| | CDC34 | CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa) |
| | RNF126 | RNF126 isoform 1. (240 aa) |
| | THOP1 | THOP1 isoform 1. (689 aa) |
| | FZR1 | FZR1 isoform 4. (420 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | DCAF15 | DCAF15 isoform 1. (567 aa) |
| | DDA1 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (102 aa) |
| | ZNF738 | Zinc finger protein 738. (137 aa) |
| | IRF2BP1 | Interferon regulatory factor 2 binding protein 1. (584 aa) |
| | UBE2S | UBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) |
| | CR201_G0047492 | PRAME isoform 2. (377 aa) |
| | PPIL2 | PPIL2 isoform 1. (495 aa) |
| | UBE2L3 | Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] (154 aa) |
| | UBE2G2 | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). (165 aa) |
| | TTC3 | Tetratricopeptide repeat domain 3. (2024 aa) |
| | TMEM189-UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa) |
| | RNF114 | RNF114 isoform 2. (240 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | RNF167 | Ring finger protein 167. (375 aa) |
| | ZNRF2 | E3 ubiquitin-protein ligase ZNRF1/2. (240 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | UBE2D4 | UBE2D4 isoform 3; Belongs to the ubiquitin-conjugating enzyme family. (171 aa) |
| | CR201_G0020693 | T0070593 isoform 1. (151 aa) |
| | ANKIB1 | RBR-type E3 ubiquitin transferase. (1089 aa) |
| | RFFL | T0183779 isoform 1. (369 aa) |
| | HECW2 | HECW2 isoform 3. (1572 aa) |
| | TRIM58 | TRIM58 isoform 1. (486 aa) |
| | CR201_G0030856 | RNF187 isoform 1. (49 aa) |
| | FBXO28 | F-box protein 28. (368 aa) |
| | DTL | DTL isoform 2. (659 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa) |
| | RC3H1 | RC3H1 isoform 1. (1094 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (582 aa) |
| | RUSC1 | RUSC1 isoform 2. (899 aa) |
| | UBE2Q1 | Ubiquitin conjugating enzyme E2 Q1. (422 aa) |
| | RNF115 | Ring finger protein 115. (304 aa) |
| | UBE2U | UBE2U isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (226 aa) |
| | CR201_G0015745 | TRIM62 isoform 3. (352 aa) |
| | RNF19B | RBR-type E3 ubiquitin transferase. (629 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (352 aa) |
| | RNF186 | RNF186 isoform 1. (227 aa) |
| | UBE4B | UBE4B isoform 1. (1106 aa) |
| | UBE2J2 | Ubiquitin conjugating enzyme E2 J2. (259 aa) |
| | MARCHF8 | MARCH8 isoform 2. (291 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | MARCHF5 | Membrane associated ring-CH-type finger 5. (278 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | CR201_G0012618 | C10orf90 isoform 4. (555 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa) |
| | SYVN1 | SYVN1 isoform 3. (616 aa) |
| | PRPF19 | PRPF19 isoform 1. (523 aa) |
| | ZFP91 | E3 ubiquitin-protein ligase ZFP91 isoform X1. (524 aa) |
| | UBE2L6 | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | AMBRA1 | AMBRA1 isoform 3. (1241 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | TRIM3 | TRIM3 isoform 1. (712 aa) |
| | TRIM22 | TRIM22 isoform 3. (498 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa) |
| | TRIM34 | TRIM34 isoform 1. (842 aa) |
| | TRIM68 | TRIM68 isoform 1. (344 aa) |
| | TRIM21 | TRIM21 isoform 1. (368 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (597 aa) |
| | CBL | Cbl proto-oncogene. (905 aa) |
| | RNF26 | RNF26 isoform 1. (433 aa) |
| | KLHL42 | Kelch like family member 42. (505 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | UBE3B | UBE3B isoform 1. (1068 aa) |
| | WSB2 | WD repeat and SOCS box containing 2. (404 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (755 aa) |
| | RNF34 | E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p5 [...] (373 aa) |
| | CHFR | E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...] (619 aa) |
| | RNF6 | RNF6 isoform 2. (685 aa) |
| | UBE2L5 | Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | NHLRC3 | NHL repeat-containing protein 3. (347 aa) |
| | KBTBD6 | Kelch repeat and BTB domain containing 6. (674 aa) |
| | KBTBD7 | Kelch repeat and BTB domain containing 7. (684 aa) |
| | TPP2 | Tripeptidyl peptidase 2. (1249 aa) |
| | CDC16 | CDC16 isoform 4. (575 aa) |
| | RNF31 | T0114761 isoform 1. (1053 aa) |
| | HECTD1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | AREL1 | AREL1 isoform 1. (823 aa) |
| | IFI27 | IFI27 isoform 2. (89 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | MKRN3 | Makorin ring finger protein 3. (507 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (849 aa) |
| | NEDD4 | E3 ubiquitin-protein ligase. (937 aa) |
| | RNF111 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa) |
| | ARIH1 | RBR-type E3 ubiquitin transferase. (557 aa) |
| | CR201_G0049226 | UBE2Q2 isoform 2. (210 aa) |
| | FBXO22 | F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function (By similarity). (405 aa) |
| | CR201_G0049226-2 | UBE2Q2 isoform 1. (110 aa) |
| | CR201_G0054585 | AXIN1 isoform 6. (551 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | MGRN1 | MGRN1 isoform 2. (576 aa) |
| | BFAR | Bifunctional apoptosis regulator. (450 aa) |
| | AMFR | AMFR isoform 1. (548 aa) |
| | CR201_G0015086 | CBFB isoform 2. (161 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (874 aa) |
| | ZNRF1 | Zinc and ring finger 1. (227 aa) |
| | RNF166 | RNF166 isoform 1. (215 aa) |
| | UBE2G1 | Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | ENSPPYP00000011752 | annotation not available (89 aa) |
| | ENSPPYP00000011890 | annotation not available (224 aa) |
| | ENSPPYP00000012086 | annotation not available (110 aa) |
