STRINGSTRING
ATG16L2 ATG16L2 SH3GLB1 SH3GLB1 MCOLN3 MCOLN3 ATP13A2 ATP13A2 UVRAG UVRAG GABARAPL1 GABARAPL1 ULK1 ULK1 CR201_G0016717 CR201_G0016717 TM9SF1 TM9SF1 CHMP4A CHMP4A PRKD1 PRKD1 ATG14 ATG14 LOC100445631 LOC100445631 GABARAPL2 GABARAPL2 MAP1LC3B MAP1LC3B CHMP1A CHMP1A CR201_G0041408 CR201_G0041408 GABARAP GABARAP CR201_G0024013 CR201_G0024013 CHMP6 CHMP6 VMP1 VMP1 CALCOCO2 CALCOCO2 ENSPPYP00000011173 ENSPPYP00000011173 TMEM150B TMEM150B CHMP2A CHMP2A MAP1LC3C MAP1LC3C CHMP4B CHMP4B MAP1LC3A MAP1LC3A SNAP29 SNAP29 CHMP3 CHMP3 ATG9A ATG9A ATG16L1 ATG16L1 RAB7A RAB7A CHMP2B CHMP2B TEX264 TEX264 WDFY3 WDFY3 JMY JMY STING1 STING1 TECPR1 TECPR1 CHMP7 CHMP7 ENTPD4 ENTPD4 RB1CC1 RB1CC1 CHMP4C CHMP4C TMEM74 TMEM74 CHMP5 CHMP5 STX17 STX17 ATP6AP2 ATP6AP2 ENSPPYP00000022952 ENSPPYP00000022952 LAMP2 LAMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG16L2ATG16L2 isoform 3. (706 aa)
SH3GLB1Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] (365 aa)
MCOLN3MCOLN3 isoform 4. (553 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1175 aa)
UVRAGUV radiation resistance associated. (699 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (85 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa)
CR201_G0016717RUBCNL isoform 6. (570 aa)
TM9SF1Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (604 aa)
CHMP4ACHMP4A isoform 4. (258 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa)
ATG14Autophagy related 14. (492 aa)
LOC100445631GABARAPL1 isoform 2. (113 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
MAP1LC3BMAP1LC3B isoform 1. (129 aa)
CHMP1ACharged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (196 aa)
CR201_G0041408WDR81 isoform 4. (691 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa)
CR201_G0024013WIPI1 isoform 2. (251 aa)
CHMP6Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (178 aa)
VMP1Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Required for autophagosome formation (By similarity). Belongs to the VMP1 family. (406 aa)
CALCOCO2Calcium-binding and coiled-coil domain-containing protein 2; Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen- containing autophagosome maturation (By similarity). Bacteria targeting [...] (447 aa)
ENSPPYP00000011173annotation not available (222 aa)
TMEM150BTransmembrane protein 150B. (233 aa)
CHMP2ACHMP2A isoform 1. (222 aa)
MAP1LC3CMAP1LC3C isoform 1. (147 aa)
CHMP4BCHMP4B isoform 1. (210 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
SNAP29Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. (258 aa)
CHMP3Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (222 aa)
ATG9AAutophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (838 aa)
ATG16L1Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...] (624 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa)
CHMP2BCharged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (213 aa)
TEX264TEX264 isoform 10. (304 aa)
WDFY3WDFY3 isoform 1. (3520 aa)
JMYJMY isoform 1. (618 aa)
STING1Transmembrane protein 173. (379 aa)
TECPR1Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity); Belongs to the TECPR1 family. (1165 aa)
CHMP7Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. (453 aa)
ENTPD4ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. (541 aa)
RB1CC1RB1CC1 isoform 1. (1594 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
TMEM74TMEM74 isoform 1. (267 aa)
CHMP5Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa)
STX17STX17 isoform 1; Belongs to the syntaxin family. (302 aa)
ATP6AP2Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...] (350 aa)
ENSPPYP00000022952annotation not available (197 aa)
LAMP2Lysosomal associated membrane protein 2. (410 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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