STRINGSTRING
MLN MLN REEP2 REEP2 WNT8A WNT8A CXCL14 CXCL14 ARRDC3 ARRDC3 HOMER1 HOMER1 PDE4D PDE4D CCL28 CCL28 ENSPPYP00000017161 ENSPPYP00000017161 IL2 IL2 CXCL13 CXCL13 CXCL11 CXCL11 CXCL10 CXCL10 CXCL9 CXCL9 CXCL2 CXCL2 CXCL3 CXCL3 CXCL5 CXCL5 PPBP PPBP PF4 PF4 CXCL1 CXCL1 PF4V1 PF4V1 CXCL6 CXCL6 LOC100437488 LOC100437488 NPFFR2 NPFFR2 NMU NMU UCHL1 UCHL1 PACRGL PACRGL CCR2 CCR2 UTS2B UTS2B RTP2 RTP2 RTP4 RTP4 RTP1 RTP1 DVL3 DVL3 P2RY1 P2RY1 AGTR1 AGTR1 RYK RYK PDCD6IP PDCD6IP CX3CR1 CX3CR1 CCRL2 CCRL2 RTP3 RTP3 UCN2 UCN2 GNAI2 GNAI2 WNT5A WNT5A PROK2 PROK2 GHRL GHRL ENSPPYP00000014984 ENSPPYP00000014984 RTP5 RTP5 PRLH PRLH SAG SAG CCL20 CCL20 WNT10A WNT10A WNT6 WNT6 FZD7 FZD7 STAT1 STAT1 GCG GCG POMC POMC UCN UCN CNRIP1 CNRIP1 CR201_G0049470 CR201_G0049470 NMS NMS WNT7B WNT7B ZNRF3 ZNRF3 GRK3 GRK3 ADORA2A ADORA2A GNAZ GNAZ TFF2 TFF2 CLIC6 CLIC6 MRAP MRAP ENSPPYP00000012602 ENSPPYP00000012602 EDN3 EDN3 GNAS GNAS GHRH GHRH ITCH ITCH ASIP ASIP PDYN PDYN OXT OXT AVP AVP PRNP PRNP FPR1 FPR1 CR201_G0047121 CR201_G0047121 CR201_G0029716 CR201_G0029716 CXCL17 CXCL17 ENSPPYP00000011229 ENSPPYP00000011229 CR201_G0044078 CR201_G0044078 APLP1 APLP1 PTGER1 PTGER1 RLN3 RLN3 DNM2 DNM2 S1PR2 S1PR2 CCL25 CCL25 C3 C3 FEM1A FEM1A CR201_G0044254 CR201_G0044254 GNA11 GNA11 PALM PALM ADCYAP1 ADCYAP1 GNAL GNAL ENSPPYP00000010071 ENSPPYP00000010071 CR201_G0055603 CR201_G0055603 LOC100460653 LOC100460653 ENSPPYP00000010037 ENSPPYP00000010037 PPP1R9B PPP1R9B TAC4 TAC4 PHB PHB GIP GIP NPB NPB ITGB4 ITGB4 SLC9A3R1 SLC9A3R1 GNA13 GNA13 PSMC5 PSMC5 ACE ACE HCRT HCRT PPY PPY WNT3 WNT3 WNT9B WNT9B RNF43 RNF43 LOC100439906 LOC100439906 LOC100439532 LOC100439532 CCL18 CCL18 CCL23 CCL23 CCL15 CCL15 CCL16 CCL16 CCL5 CCL5 CCL1 CCL1 CCL11 CCL11 CCL7 CCL7 CCL8 CCL8 CCL2 CCL2 DVL2 DVL2 DLG4 DLG4 C1QBP C1QBP ARRB2 ARRB2 VPS35 VPS35 CR201_G0036829 CR201_G0036829 AGRP AGRP CKLF CKLF CCL17 CCL17 CX3CL1 CX3CL1 GNAO1 GNAO1 RPGRIP1L RPGRIP1L GPRC5B GPRC5B SLC9A3R2 SLC9A3R2 NPW NPW STUB1 STUB1 NMB NMB HOMER2 HOMER2 NEDD4 NEDD4 BDKRB2 BDKRB2 CCDC88C CCDC88C AKAP5 AKAP5 GPHB5 GPHB5 SAV1 SAV1 ENSPPYP00000005897 ENSPPYP00000005897 PMCH PMCH NTS NTS AVPR1A AVPR1A TAC3 TAC3 NPFF NPFF WNT1 WNT1 WNT10B WNT10B BICD1 BICD1 SPX SPX TULP3 TULP3 ARHGEF12 ARHGEF12 GRM5 GRM5 WNT11 WNT11 ARRB1 ARRB1 P2RY2 P2RY2 CCKBR CCKBR TUB TUB ADM ADM PTH PTH CALCB CALCB SAA2 SAA2 GPHA2 GPHA2 BBS1 BBS1 GRK2 GRK2 GAL GAL SCT SCT ADRB1 ADRB1 ADRA2A ADRA2A WNT8B WNT8B ENSPPYP00000002678 ENSPPYP00000002678 C10orf99 C10orf99 CXCL12 CXCL12 BAMBI BAMBI UCN3 UCN3 DVL1 DVL1 NPPA NPPA WNT4 WNT4 RSPO1 RSPO1 EDN2 EDN2 PTCH2 PTCH2 JAK1 JAK1 INSL5 INSL5 S1PR1 S1PR1 GNAI3 GNAI3 GNAT2 GNAT2 WNT2B WNT2B XCL1 XCL1 XCL1-2 XCL1-2 MYOC MYOC DNM3 DNM3 KISS1 KISS1 CNIH4 CNIH4 WNT9A WNT9A WNT3A WNT3A AGT AGT MRAP2 MRAP2 FYN FYN RSPO3 RSPO3 CR201_G0036895 CR201_G0036895 PACRG PACRG GNA12 GNA12 CCL24 CCL24 CCL26 CCL26 RALA RALA ENSPPYP00000019816 ENSPPYP00000019816 NPY NPY TAC1 TAC1 FZD1 FZD1 GNAT3 GNAT3 GNAI1 GNAI1 MAGI2 MAGI2 CAV2 CAV2 WNT2 WNT2 WNT16 WNT16 KIAA1549 KIAA1549 ENSPPYP00000020449 ENSPPYP00000020449 DEFB1 DEFB1 LOC112131751 LOC112131751 LOC100434290 LOC100434290 LOC100435661 LOC100435661 LOC100436028 LOC100436028 LOC112134719 LOC112134719 PNOC PNOC CR201_G0033322 CR201_G0033322 PENK PENK SDCBP SDCBP CTHRC1 CTHRC1 MSMP MSMP CREB3 CREB3 CCL21 CCL21 CCL19 CCL19 CCL27 CCL27 GNA14 GNA14 GNAQ GNAQ PTCH1 PTCH1 C5 C5 USP20 USP20 QRFP QRFP ADA2 ADA2 LOC100445600 LOC100445600 NDP NDP CR201_G0023677 CR201_G0023677 GPRASP2 GPRASP2 FLNA FLNA ARR3 ARR3 ENSPPYP00000023537 ENSPPYP00000023537 CALCA CALCA ENSPPYP00000023642 ENSPPYP00000023642 NES NES CR201_G0003143 CR201_G0003143 S100A14 S100A14 ARHGEF11 ARHGEF11 LRP6 LRP6 NARS NARS ENSPPYP00000024161 ENSPPYP00000024161 GPRASP1 GPRASP1 CXCL16 CXCL16 ENSPPYP00000024539 ENSPPYP00000024539 EDNRB EDNRB RAPGEF2 RAPGEF2 EDN1 EDN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLNMLN isoform 1. (138 aa)
REEP2Receptor expression-enhancing protein. (254 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CXCL14C-X-C motif chemokine ligand 14. (111 aa)
ARRDC3Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. (413 aa)
HOMER1Homer scaffold protein 1. (354 aa)
PDE4DPhosphodiesterase. (679 aa)
CCL28C-C motif chemokine. (127 aa)
ENSPPYP00000017161annotation not available (85 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
CXCL13C-X-C motif chemokine. (109 aa)
CXCL11C-X-C motif chemokine. (94 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL9C-X-C motif chemokine. (122 aa)
CXCL2C-X-C motif chemokine. (107 aa)
CXCL3C-X-C motif chemokine. (107 aa)
CXCL5C-X-C motif chemokine. (154 aa)
PPBPC-X-C motif chemokine. (128 aa)
PF4C-X-C motif chemokine. (101 aa)
CXCL1C-X-C motif chemokine. (107 aa)
PF4V1C-X-C motif chemokine. (101 aa)
CXCL6C-X-C motif chemokine. (114 aa)
LOC100437488Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NPFFR2NPFFR2 isoform 3; Belongs to the G-protein coupled receptor 1 family. (521 aa)
NMUNMU isoform 2. (174 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (223 aa)
PACRGLParkin coregulated like. (248 aa)
CCR2CCR2 isoform 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
UTS2BUTS2B isoform 1. (119 aa)
RTP2Receptor transporter protein 2. (225 aa)
RTP4RTP4 isoform 1. (246 aa)
RTP1Receptor transporter protein 1. (263 aa)
DVL3DVL3 isoform 1. (699 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
RYKRYK isoform 3. (535 aa)
PDCD6IPPDCD6IP isoform 2. (945 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCRL2CCRL2 isoform 3; Belongs to the G-protein coupled receptor 1 family. (345 aa)
RTP3Receptor transporter protein 3. (232 aa)
UCN2UCN2 isoform 1. (112 aa)
GNAI2GNAI2 isoform 1. (303 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
PROK2PROK2 isoform 2. (129 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ENSPPYP00000014984annotation not available (349 aa)
RTP5RTP5 isoform 2. (593 aa)
PRLHProlactin releasing hormone. (87 aa)
SAGSAG isoform 4. (405 aa)
CCL20C-C motif chemokine. (96 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (422 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
STAT1Signal transducer and activator of transcription. (766 aa)
GCGGCG isoform 1. (180 aa)
POMCPOMC isoform 1. (266 aa)
UCNUCN isoform 1. (129 aa)
CNRIP1Cannabinoid receptor interacting protein 1. (164 aa)
CR201_G0049470Receptor expression-enhancing protein. (175 aa)
NMSNMS isoform 1. (153 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ZNRF3ZNRF3 isoform 2. (881 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (674 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
GNAZGNAZ isoform 1. (350 aa)
TFF2Trefoil factor 2. (129 aa)
CLIC6Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (677 aa)
MRAPMRAP isoform 4. (101 aa)
ENSPPYP00000012602annotation not available (613 aa)
EDN3EDN3 isoform 1. (229 aa)
GNASGNAS isoform 2. (1037 aa)
GHRHGHRH isoform 1. (45 aa)
ITCHE3 ubiquitin-protein ligase. (849 aa)
ASIPAgouti signaling protein. (132 aa)
PDYNPDYN isoform 1. (254 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
AVPAVP isoform 1; Belongs to the vasopressin/oxytocin family. (164 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
FPR1Formyl peptide receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CR201_G0047121Tyrosine-protein kinase. (883 aa)
CR201_G0029716SHANK1 isoform 6. (1389 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
ENSPPYP00000011229annotation not available (916 aa)
CR201_G0044078ARHGEF1 isoform 7. (764 aa)
APLP1APLP1 isoform 2. (651 aa)
PTGER1Prostaglandin E receptor 1. (402 aa)
RLN3RLN3 isoform 1. (142 aa)
DNM2DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CCL25C-C motif chemokine ligand 25. (150 aa)
C3C3 isoform 1. (1664 aa)
FEM1AFEM1A isoform 1. (581 aa)
CR201_G0044254GNA15 isoform 1. (287 aa)
GNA11GNA11 isoform 1. (358 aa)
PALMPALM isoform 3. (368 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
GNALGNAL isoform 3. (381 aa)
ENSPPYP00000010071annotation not available (610 aa)
CR201_G0055603C-C motif chemokine. (93 aa)
LOC100460653C-C motif chemokine. (93 aa)
ENSPPYP00000010037annotation not available (99 aa)
PPP1R9BPPP1R9B isoform 1. (729 aa)
TAC4TAC4 isoform 7. (96 aa)
PHBProhibitin. (272 aa)
GIPGIP isoform 1. (124 aa)
NPBNPB isoform 2. (125 aa)
ITGB4Integrin beta. (1814 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
GNA13G protein subunit alpha 13. (377 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
ACEAngiotensin-converting enzyme. (1270 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
PPYPancreatic polypeptide. (95 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
RNF43RNF43 isoform 2. (452 aa)
LOC100439906C-C motif chemokine 4 isoform X4. (92 aa)
LOC100439532C-C motif chemokine. (92 aa)
CCL18C-C motif chemokine. (89 aa)
CCL23C-C motif chemokine ligand 23. (120 aa)
CCL15C-C motif chemokine. (113 aa)
CCL16C-C motif chemokine. (120 aa)
CCL5C-C motif chemokine. (91 aa)
CCL1C-C motif chemokine. (96 aa)
CCL11C-C motif chemokine. (97 aa)
CCL7C-C motif chemokine. (109 aa)
CCL8C-C motif chemokine. (109 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
DVL2DVL2 isoform 1. (677 aa)
DLG4DLG4 isoform 3; Belongs to the MAGUK family. (690 aa)
C1QBPComplement C1q binding protein. (281 aa)
ARRB2Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] (321 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
CR201_G0036829NECAB2 isoform 3. (322 aa)
AGRPAgouti related neuropeptide. (132 aa)
CKLFChemokine like factor. (152 aa)
CCL17C-C motif chemokine. (94 aa)
CX3CL1CX3CL1 isoform 1. (397 aa)
GNAO1GNAO1 isoform 1. (354 aa)
RPGRIP1LRPGRIP1L isoform 3. (1315 aa)
GPRC5BGPRC5B isoform 1. (403 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
NPWNeuropeptide W. (165 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
NMBNMB isoform 2. (154 aa)
HOMER2HOMER2 isoform 1. (397 aa)
NEDD4E3 ubiquitin-protein ligase. (937 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CCDC88CCCDC88C isoform 2. (1924 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
GPHB5Glycoprotein hormone subunit beta 5. (130 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
ENSPPYP00000005897annotation not available (603 aa)
PMCHPro-melanin concentrating hormone. (165 aa)
NTSNTS isoform 1. (170 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
TAC3TAC3 isoform 1. (121 aa)
NPFFPro-FMRFamide-related neuropeptide FF isoform X2. (113 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (317 aa)
BICD1BICD1 isoform 4. (975 aa)
SPXSpexin hormone. (116 aa)
TULP3TULP3 isoform 2. (439 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
GRM5GRM5 isoform 4. (1127 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ARRB1ARRB1 isoform 2. (473 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
CCKBRCCKBR isoform 1; Belongs to the G-protein coupled receptor 1 family. (447 aa)
TUBTubby-like protein; Belongs to the TUB family. (561 aa)
ADMAdrenomedullin. (185 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
CALCBCALCB isoform 1. (127 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
GPHA2Glycoprotein hormone subunit alpha 2. (129 aa)
BBS1T0110064 isoform 1. (593 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
SCTSCT isoform 1. (83 aa)
ADRB1ADRB1 isoform 1. (345 aa)
ADRA2AADRA2A isoform 1. (450 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ENSPPYP00000002678annotation not available (281 aa)
C10orf99Chromosome 10 open reading frame 99. (81 aa)
CXCL12CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
UCN3UCN3 isoform 1. (161 aa)
DVL1DVL1 isoform 2. (594 aa)
NPPANatriuretic peptide A. (159 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
RSPO1RSPO1 isoform 1. (263 aa)
EDN2EDN2 isoform 2. (178 aa)
PTCH2PTCH2 isoform 1. (1203 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
INSL5INSL5 isoform 1. (135 aa)
S1PR1S1PR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
XCL1XCL2 isoform 1. (114 aa)
XCL1-2XCL1 isoform 1. (114 aa)
MYOCMYOC isoform 2. (490 aa)
DNM3DNM3 isoform 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
KISS1KISS1 isoform 2. (147 aa)
CNIH4Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. (139 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (318 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
AGTAGT isoform 1; Belongs to the serpin family. (485 aa)
MRAP2MRAP2 isoform 1. (181 aa)
FYNTyrosine-protein kinase. (537 aa)
RSPO3RSPO3 isoform 2. (292 aa)
CR201_G0036895PRKN isoform 8. (335 aa)
PACRGParkin coregulated. (257 aa)
GNA12GNA12 isoform 1. (381 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CCL26C-C motif chemokine 26. (94 aa)
RALARAS like proto-oncogene A. (206 aa)
ENSPPYP00000019816annotation not available (197 aa)
NPYNPY isoform 1. (97 aa)
TAC1TAC1 isoform 1. (129 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
GNAT3GNAT3 isoform 1. (355 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa)
MAGI2MAGI2 isoform 1. (1339 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
KIAA1549KIAA1549 isoform 1. (1901 aa)
ENSPPYP00000020449annotation not available (62 aa)
DEFB1DEFB1 isoform 1. (68 aa)
LOC112131751Beta-defensin 109. (87 aa)
LOC100434290Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (65 aa)
LOC100435661DEFB103B isoform 1. (67 aa)
LOC100436028DEFB4A isoform 1. (64 aa)
LOC112134719Beta-defensin 130-like. (79 aa)
PNOCPrepronociceptin. (176 aa)
CR201_G0033322SFRP1 isoform 1. (260 aa)
PENKPENK isoform 3. (267 aa)
SDCBPSDCBP isoform 3. (297 aa)
CTHRC1CTHRC1 isoform 3. (232 aa)
MSMPBeta-microseminoprotein. (139 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
CCL21CCL21 isoform 1. (132 aa)
CCL19C-C motif chemokine. (98 aa)
CCL27C-C motif chemokine ligand 27. (112 aa)
GNA14G protein subunit alpha 14. (355 aa)
GNAQG protein subunit alpha q. (359 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
C5C5 isoform 1. (1676 aa)
USP20Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins de [...] (913 aa)
QRFPQRFP isoform 1. (136 aa)
ADA2Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). (511 aa)
LOC100445600DEFB130A isoform 1. (79 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
CR201_G0023677PYY isoform 1. (70 aa)
GPRASP2G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors; Belongs to the GPRASP family. (838 aa)
FLNAFLNA isoform 7. (2647 aa)
ARR3ARR3 isoform 3. (388 aa)
ENSPPYP00000023537annotation not available (121 aa)
CALCACalcitonin related polypeptide alpha. (142 aa)
ENSPPYP00000023642annotation not available (93 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1632 aa)
CR201_G0003143CNRIP1 isoform 3. (166 aa)
S100A14S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
ARHGEF11ARHGEF11 isoform 1. (1578 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1000 aa)
NARSNARS isoform 2. (601 aa)
ENSPPYP00000024161annotation not available (67 aa)
GPRASP1G protein-coupled receptor associated sorting protein 1. (1395 aa)
CXCL16CXCL16 isoform 5. (250 aa)
ENSPPYP00000024539annotation not available (66 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
RAPGEF2RAPGEF2 isoform 1. (1331 aa)
EDN1EDN1 isoform 1. (212 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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