STRINGSTRING
ACVR1 ACVR1 TGFB2 TGFB2 MDM4 MDM4 EFNA1 EFNA1 CCN1 CCN1 HEYL HEYL BMPR1A BMPR1A TBX5 TBX5 SMAD6 SMAD6 ZFPM1 ZFPM1 SMAD4 SMAD4 BMPR2 BMPR2 TGFBR2 TGFBR2 SLIT3 SLIT3 CR201_G0047764 CR201_G0047764 ENSPPYP00000018739 ENSPPYP00000018739 HEY2 HEY2 TWIST1 TWIST1 GATA4 GATA4 HEY1 HEY1 CR201_G0027392 CR201_G0027392 NOTCH1 NOTCH1 BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
EFNA1EFNA1 isoform 1; Belongs to the ephrin family. (205 aa)
CCN1Cellular communication network factor 1. (381 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TBX5T-box transcription factor 5. (518 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
ZFPM1ZFPM1 isoform 1. (344 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SLIT3SLIT3 isoform 2. (1552 aa)
CR201_G0047764Transcription factor SOX. (308 aa)
ENSPPYP00000018739annotation not available (186 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TWIST1Twist family bHLH transcription factor 1. (203 aa)
GATA4GATA binding protein 4. (442 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
CR201_G0027392OLFM1 isoform 6. (357 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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