STRINGSTRING
ENSPPYP00000012305 ENSPPYP00000012305 LOC100452886 LOC100452886 ENSPPYP00000000154 ENSPPYP00000000154 ARPC5 ARPC5 SPTA1 SPTA1 LMNA LMNA LOR LOR TEKT2 TEKT2 CR201_G0015864 CR201_G0015864 CROCC CROCC ENSPPYP00000002111 ENSPPYP00000002111 AGRN AGRN CR201_G0054189 CR201_G0054189 TUBAL3 TUBAL3 ANK3 ANK3 CCDC6 CCDC6 INA INA ADD3 ADD3 SPTBN2 SPTBN2 ENSPPYP00000004309 ENSPPYP00000004309 CR201_G0053675 CR201_G0053675 BICD1 BICD1 PRPH PRPH KRT2 KRT2 YEATS4 YEATS4 ARPC3 ARPC3 ENSPPYP00000005898 ENSPPYP00000005898 CR201_G0004139 CR201_G0004139 ACTR10 ACTR10 CR201_G0009827 CR201_G0009827 TUBGCP4 TUBGCP4 TLN2 TLN2 TPM1 TPM1 SYNM SYNM JPT2 JPT2 PPL PPL TEKT5 TEKT5 TUBB3 TUBB3 TEKT1 TEKT1 TEKT3 TEKT3 GFAP GFAP TUBG2 TUBG2 KRT16 KRT16 KRT15 KRT15 ACTG1 ACTG1 TUBD1 TUBD1 KRT9 KRT9 KRT14 KRT14 TUBB6 TUBB6 EPB41L3 EPB41L3 CR201_G0043999 CR201_G0043999 ENSPPYP00000011873 ENSPPYP00000011873 ENSPPYP00000011927 ENSPPYP00000011927 ENSPPYP00000011942 ENSPPYP00000011942 TUBE1 TUBE1 ANKRD60 ANKRD60 TUBB1 TUBB1 NEFH NEFH ENSPPYP00000013420 ENSPPYP00000013420 SPTBN1 SPTBN1 ACTR3 ACTR3 EPC2 EPC2 ARPC2 ARPC2 TUBA4A TUBA4A ENSPPYP00000014962 ENSPPYP00000014962 VILL VILL BFSP2 BFSP2 PLS1 PLS1 ANK2 ANK2 SORBS2 SORBS2 ACTBL2 ACTBL2 LMNB1 LMNB1 TUBB2B TUBB2B DSP DSP TUBB TUBB CD2AP CD2AP TUBA1B TUBA1B LMNB2 LMNB2 CR201_G0002453 CR201_G0002453 TUBA1C TUBA1C TUBA8 TUBA8 DES DES ENSPPYP00000023866 ENSPPYP00000023866 ENSPPYP00000023839 ENSPPYP00000023839 ERBIN ERBIN HIP1 HIP1 CR201_G0054189-2 CR201_G0054189-2 ENSPPYP00000023230 ENSPPYP00000023230 CENPI CENPI CYLC1 CYLC1 MSN MSN DMD DMD ENSPPYP00000022418 ENSPPYP00000022418 CR201_G0054378 CR201_G0054378 LOC100434822 LOC100434822 TUBB4B TUBB4B SPTAN1 SPTAN1 EPB41L4B EPB41L4B ACTL7A ACTL7A ACTL7B ACTL7B CYLC2 CYLC2 TLN1 TLN1 PLEC PLEC CR201_G0050826 CR201_G0050826 ANK1 ANK1 NEFL NEFL CR201_G0005182 CR201_G0005182 SORBS3 SORBS3 ACTL6B ACTL6B ACTB ACTB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPYP00000012305annotation not available (493 aa)
LOC100452886TUBB8 isoform 7. (440 aa)
ENSPPYP00000000154annotation not available (424 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA [...] (151 aa)
SPTA1SPTA1 isoform 1. (2387 aa)
LMNALMNA isoform 2; Belongs to the intermediate filament family. (664 aa)
LORLOR isoform 1. (318 aa)
TEKT2TEKT2 isoform 3. (430 aa)
CR201_G0015864EPB41 isoform 1. (655 aa)
CROCCCROCC isoform 3. (1866 aa)
ENSPPYP00000002111LOW QUALITY PROTEIN: rootletin-like. (210 aa)
AGRNAGRN isoform 1. (1824 aa)
CR201_G0054189Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
ANK3ANK3 isoform 1. (4275 aa)
CCDC6Coiled-coil domain containing 6. (474 aa)
INAINA isoform 1; Belongs to the intermediate filament family. (499 aa)
ADD3ADD3 isoform 3. (706 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2389 aa)
ENSPPYP00000004309annotation not available (437 aa)
CR201_G0053675LMNTD1 isoform 9. (324 aa)
BICD1BICD1 isoform 4. (975 aa)
PRPHPRPH isoform 1; Belongs to the intermediate filament family. (470 aa)
KRT2KRT2 isoform 1; Belongs to the intermediate filament family. (646 aa)
YEATS4YEATS domain containing 4. (227 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (168 aa)
ENSPPYP00000005898annotation not available (382 aa)
CR201_G0004139Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (610 aa)
ACTR10Actin related protein 10; Belongs to the actin family. (417 aa)
CR201_G0009827Spectrin beta chain; Belongs to the spectrin family. (1818 aa)
TUBGCP4Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (658 aa)
TLN2TLN2 isoform 1. (2542 aa)
TPM1TPM1 isoform 2; Belongs to the tropomyosin family. (326 aa)
SYNMSYNM isoform 4; Belongs to the intermediate filament family. (1253 aa)
JPT2Jupiter microtubule associated homolog 2. (190 aa)
PPLPPL isoform 2. (1671 aa)
TEKT5TEKT5 isoform 1. (485 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
TEKT1TEKT1 isoform 1. (418 aa)
TEKT3TEKT3 isoform 1. (490 aa)
GFAPGlial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. (431 aa)
TUBG2Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
KRT16KRT16 isoform 1; Belongs to the intermediate filament family. (474 aa)
KRT15KRT15 isoform 1; Belongs to the intermediate filament family. (456 aa)
ACTG1ACTG1 isoform 10. (375 aa)
TUBD1TUBD1 isoform 13; Belongs to the tubulin family. (453 aa)
KRT9LOW QUALITY PROTEIN: keratin, type I cytoskeletal 9. (627 aa)
KRT14KRT14 isoform 1; Belongs to the intermediate filament family. (475 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
EPB41L3EPB41L3 isoform 2. (792 aa)
CR201_G0043999SPTBN4 isoform 1. (2409 aa)
ENSPPYP00000011873annotation not available (417 aa)
ENSPPYP00000011927annotation not available (116 aa)
ENSPPYP00000011942annotation not available (117 aa)
TUBE1Tubulin epsilon 1; Belongs to the tubulin family. (475 aa)
ANKRD60ANKRD60 isoform 1. (140 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
NEFHNEFH isoform 1; Belongs to the intermediate filament family. (999 aa)
ENSPPYP00000013420annotation not available (154 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2342 aa)
ACTR3Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] (418 aa)
EPC2Enhancer of polycomb homolog. (767 aa)
ARPC2Actin-related protein 2/3 complex subunit 2; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promot [...] (300 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
ENSPPYP00000014962annotation not available (447 aa)
VILLVILL isoform 1. (855 aa)
BFSP2BFSP2 isoform 3; Belongs to the intermediate filament family. (443 aa)
PLS1PLS1 isoform 1. (631 aa)
ANK2ANK2 isoform 1. (4018 aa)
SORBS2SORBS2 isoform 7. (1298 aa)
ACTBL2Actin beta like 2. (376 aa)
LMNB1LMNB1 isoform 1; Belongs to the intermediate filament family. (586 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
DSPDSP isoform 1. (2871 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (444 aa)
CD2APCD2 associated protein. (639 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
LMNB2LMNB2 isoform 2; Belongs to the intermediate filament family. (577 aa)
CR201_G0002453EPB41L3 isoform 10. (218 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (476 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
DESDES isoform 1; Belongs to the intermediate filament family. (153 aa)
ENSPPYP00000023866annotation not available (88 aa)
ENSPPYP00000023839annotation not available (519 aa)
ERBINErbb2 interacting protein. (1419 aa)
HIP1HIP1 isoform 5. (830 aa)
CR201_G0054189-2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ENSPPYP00000023230annotation not available (111 aa)
CENPICentromere protein I. (756 aa)
CYLC1CYLC1 isoform 2. (639 aa)
MSNMSN isoform 6. (577 aa)
DMDDMD isoform 3. (3618 aa)
ENSPPYP00000022418annotation not available (435 aa)
CR201_G0054378TEKT4 isoform 2. (433 aa)
LOC100434822TUBA3C isoform 1. (450 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (388 aa)
SPTAN1SPTAN1 isoform 10. (2538 aa)
EPB41L4BEPB41L4B isoform 2. (821 aa)
ACTL7AACTL7A isoform 1; Belongs to the actin family. (435 aa)
ACTL7BACTL7B isoform 1; Belongs to the actin family. (415 aa)
CYLC2CYLC2 isoform 1. (349 aa)
TLN1TLN1 isoform 1. (2541 aa)
PLECPLEC isoform 2. (2298 aa)
CR201_G0050826IQANK1 isoform 2. (229 aa)
ANK1Ankyrin-1 isoform X1. (1695 aa)
NEFLNeurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. (543 aa)
CR201_G0005182NEFM isoform 1; Belongs to the intermediate filament family. (841 aa)
SORBS3SORBS3 isoform 3. (671 aa)
ACTL6BACTL6B isoform 1; Belongs to the actin family. (345 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.