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| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | GRAMD1A | GRAMD1A isoform 3. (750 aa) |
| | ENSPPYP00000011173 | annotation not available (222 aa) |
| | TBC1D17 | TBC1 domain family member 17. (648 aa) |
| | TMEM150B | Transmembrane protein 150B. (233 aa) |
| | CHMP2A | CHMP2A isoform 1. (222 aa) |
| | MAP1LC3C | MAP1LC3C isoform 1. (147 aa) |
| | TMEM230 | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa) |
| | CHMP4B | CHMP4B isoform 1. (210 aa) |
| | MAP1LC3A | Microtubule associated protein 1 light chain 3 alpha. (121 aa) |
| | TP53INP2 | TP53INP2 isoform 1. (212 aa) |
| | SNAP29 | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. (258 aa) |
| | CHMP3 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (222 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (410 aa) |
| | WASHC1 | WAS protein family homolog 1. (467 aa) |
| | RUFY4 | RUFY4 isoform 7. (607 aa) |
| | ATG9A | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (838 aa) |
| | ATG16L1 | Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...] (624 aa) |
| | ATG4B | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (468 aa) |
| | RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa) |
| | ADPRH | ADPRH isoform 1. (357 aa) |
| | CHMP2B | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (213 aa) |
| | TEX264 | TEX264 isoform 10. (304 aa) |
| | MAP1LC3B | MAP1LC3B isoform 1. (129 aa) |
| | FYCO1 | FYVE and coiled-coil domain containing 1. (1478 aa) |
| | TBC1D5 | TBC1D5 isoform 1. (784 aa) |
| | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa) |
| | HTT | HTT isoform 1. (3130 aa) |
| | HPSE | HPSE isoform 1. (545 aa) |
| | WDFY3 | WDFY3 isoform 1. (3520 aa) |
| | ENSPPYP00000017156 | annotation not available (234 aa) |
| | JMY | JMY isoform 1. (618 aa) |
| | STING1 | Transmembrane protein 173. (379 aa) |
| | RAB24 | RAB24, member RAS oncogene family. (204 aa) |
| | SQSTM1 | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] (436 aa) |
| | RAB23 | RAB23, member RAS oncogene family. (237 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (275 aa) |
| | WIPI2 | WIPI2 isoform 1. (429 aa) |
| | TECPR1 | Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity); Belongs to the TECPR1 family. (1165 aa) |
| | ATG9B | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa) |
| | CHMP7 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. (453 aa) |
| | ENTPD4 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. (541 aa) |
| | RB1CC1 | RB1CC1 isoform 1. (1594 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (233 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (240 aa) |
| | TMEM74 | TMEM74 isoform 1. (267 aa) |
| | MAPK15 | MAPK15 isoform 3. (546 aa) |
| | CHMP5 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa) |
| | C9orf72 | C9orf72-SMCR8 complex subunit. (481 aa) |
| | UBQLN1 | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] (577 aa) |
| | STX17 | STX17 isoform 1; Belongs to the syntaxin family. (302 aa) |
| | SRPX | Sushi repeat containing protein X-linked. (462 aa) |
| | ATP6AP2 | Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...] (350 aa) |
| | TBC1D25 | TBC1D25 isoform 1. (616 aa) |
| | UBQLN2 | UBQLN2 isoform 1. (624 aa) |
| | ENSPPYP00000022952 | annotation not available (197 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (410 aa) |
| | ENSPPYP00000023462 | Ferritin heavy chain. (188 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (435 aa) |
| | LRRK2 | LRRK2 isoform 3. (1560 aa) |
| | ENSPPYP00000024651 | annotation not available (188 aa) |
| | CHMP1A | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (196 aa) |
| | CR201_G0041408 | WDR81 isoform 4. (691 aa) |
| | GABARAP | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa) |
| | PLEKHM1 | PLEKHM1 isoform 1. (564 aa) |
| | CR201_G0023764 | PLEKHM1 isoform 4. (241 aa) |
| | NBR1 | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. (966 aa) |
| | BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa) |
| | HAP1 | HAP1 isoform 2. (662 aa) |
| | CR201_G0024013 | WIPI1 isoform 2. (251 aa) |
| | GAA | Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. (952 aa) |
| | CHMP6 | Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (178 aa) |
| | VMP1 | Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Required for autophagosome formation (By similarity). Belongs to the VMP1 family. (406 aa) |
| | OSBPL7 | Oxysterol-binding protein; Belongs to the OSBP family. (842 aa) |
| | CALCOCO2 | Calcium-binding and coiled-coil domain-containing protein 2; Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen- containing autophagosome maturation (By similarity). Bacteria targeting [...] (447 aa) |
| | RAB12 | RAB12 isoform 1. (340 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | ENSPPYP00000000132 | annotation not available (136 aa) |
| | UBQLN4 | UBQLN4 isoform 1. (600 aa) |
| | SH3GLB1 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] (365 aa) |
| | MCOLN3 | MCOLN3 isoform 4. (553 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1175 aa) |
| | OPTN | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (347 aa) |
| | NCOA4 | NCOA4 isoform 2. (614 aa) |
| | NRBF2 | Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity); Belongs to the NRBF family. (287 aa) |
| | TBC1D12 | TBC1D12 isoform 1. (772 aa) |
| | VTI1A | Vesicle transport through interaction with t-SNAREs 1A. (217 aa) |
| | FTH1 | Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. (183 aa) |
| | AMBRA1 | AMBRA1 isoform 3. (1241 aa) |
| | TRIM21 | TRIM21 isoform 1. (368 aa) |
| | ATG16L2 | ATG16L2 isoform 3. (706 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa) |
| | GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1. (85 aa) |
| | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. (421 aa) |
| | VPS33A | T0002578 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (596 aa) |
| | ULK1 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa) |
| | CR201_G0016717 | RUBCNL isoform 6. (570 aa) |
| | TM9SF1 | Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (604 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa) |
| | ATG14 | Autophagy related 14. (492 aa) |
| | VPS18 | VPS18 core subunit of CORVET and HOPS complexes. (973 aa) |
| | DAPK2 | DAPK2 isoform 4; Belongs to the protein kinase superfamily. (360 aa) |
| | ULK3 | Unc-51 like kinase 3. (483 aa) |
| | LOC100445631 | GABARAPL1 isoform 2. (113 aa) |
| | MEFV | MEFV isoform 4. (780 aa) |
| | CLN3 | Battenin. (438 aa) |
