STRINGSTRING
PLPP3 PLPP3 CNST CNST COG2 COG2 RAB29 RAB29 ENSPPYP00000000352 ENSPPYP00000000352 LGR6 LGR6 NMNAT2 NMNAT2 STX6 STX6 KLHL20 KLHL20 VAMP4 VAMP4 TMEM79 TMEM79 SYT11 SYT11 SCAMP3 SCAMP3 GBA GBA RAB13 RAB13 GOLPH3L GOLPH3L AP4B1 AP4B1 PIFO PIFO WLS WLS YIPF1 YIPF1 AZIN2 AZIN2 VAMP3 VAMP3 USP6NL USP6NL OPTN OPTN ARL5B ARL5B HTR7 HTR7 PI4K2A PI4K2A GBF1 GBF1 VTI1A VTI1A CHST3 CHST3 VPS51 VPS51 MS4A7 MS4A7 CR201_G0041652 CR201_G0041652 MS4A6A MS4A6A OSBP OSBP CHST1 CHST1 PIK3C2A PIK3C2A DENND5A DENND5A ARFIP2 ARFIP2 ARAP1 ARAP1 RAB30 RAB30 RAB38 RAB38 ENSPPYP00000004475 ENSPPYP00000004475 CR201_G0006066 CR201_G0006066 BACE1 BACE1 SORL1 SORL1 CR201_G0036182 CR201_G0036182 M6PR M6PR ENSPPYP00000004926 ENSPPYP00000004926 CCDC91 CCDC91 BICD1 BICD1 MARCH9 MARCH9 LGR5 LGR5 ARL1 ARL1 PHETA1 PHETA1 ATXN2 ATXN2 NBEA NBEA POSTN POSTN COG6 COG6 COG3 COG3 ATP7B ATP7B ATP11A ATP11A PRKD1 PRKD1 AP4S1 AP4S1 TRAPPC6B TRAPPC6B PLD4 PLD4 CLBA1 CLBA1 CHAC1 CHAC1 SLC24A5 SLC24A5 ATP8B4 ATP8B4 AP4E1 AP4E1 RAB11A RAB11A SCAMP2 SCAMP2 SCAMP5 SCAMP5 FURIN FURIN BAIAP3 BAIAP3 CORO7 CORO7 COG7 COG7 CR201_G0034261 CR201_G0034261 CLN3 CLN3 STX4 STX4 C16orf70 C16orf70 CHST4 CHST4 CHST6 CHST6 CHST5 CHST5 ATP2C2 ATP2C2 ENSPPYP00000008720 ENSPPYP00000008720 VPS53 VPS53 INPP5K INPP5K SLC2A4 SLC2A4 STX8 STX8 LLGL1 LLGL1 MYO18A MYO18A C17H17orf75 C17H17orf75 GRN GRN BECN1 BECN1 CA4 CA4 CR201_G0024013 CR201_G0024013 COG1 COG1 GGA3 GGA3 TEPSIN TEPSIN CLTC CLTC RAB31 RAB31 ATP8B1 ATP8B1 RELCH RELCH ATP9B ATP9B SLC66A2 SLC66A2 CR201_G0052494 CR201_G0052494 ATP8B3 ATP8B3 PLEKHJ1 PLEKHJ1 GPR108 GPR108 AP1M2 AP1M2 DNM2 DNM2 YIPF2 YIPF2 STX10 STX10 CLIP3 CLIP3 TRAPPC6A TRAPPC6A SNAP25 SNAP25 TMEM230 TMEM230 MMP24 MMP24 ARFGEF2 ARFGEF2 ATP9A ATP9A STX16 STX16 GNAS GNAS ARFRP1 ARFRP1 DOP1B DOP1B BACE2 BACE2 CLTCL1 CLTCL1 AP1B1 AP1B1 CABP7 CABP7 RNF215 RNF215 GGA1 GGA1 CBY1 CBY1 PHETA2 PHETA2 GCC2 GCC2 AFTPH AFTPH VPS54 VPS54 PREPL PREPL BIRC6 BIRC6 YIPF4 YIPF4 SLC30A6 SLC30A6 DPY30 DPY30 RAB10 RAB10 EIPR1 EIPR1 TGOLN2 TGOLN2 ARL5A ARL5A CR201_G0050356 CR201_G0050356 MARCHF4 MARCHF4 ATG9A ATG9A AP1S3 AP1S3 BOK BOK ENSPPYP00000014947 ENSPPYP00000014947 SMPD4 SMPD4 TBC1D23 TBC1D23 CLASP2 CLASP2 ATP2C1 ATP2C1 CHST2 CHST2 MME MME NSG1 NSG1 LAP3 LAP3 PI4K2B PI4K2B ATP8A1 ATP8A1 TMEM165 TMEM165 AP1AR AP1AR SLC10A7 SLC10A7 ARFIP1 ARFIP1 MARCHF1 MARCHF1 GOLPH3 GOLPH3 SCAMP1 SCAMP1 RHOBTB3 RHOBTB3 PCSK1 PCSK1 PAM PAM TGFBI TGFBI CD74 CD74 NDST1 NDST1 NSG2 NSG2 CLTB CLTB KIF13A KIF13A HLA-DRB5 HLA-DRB5 CR201_G0016196 CR201_G0016196 TJAP1 TJAP1 DOP1A DOP1A FUT9 FUT9 CLVS2 CLVS2 RAB32 RAB32 IGF2R IGF2R CR201_G0016191 CR201_G0016191 ENSPPYP00000019293 ENSPPYP00000019293 HLA-DQB2 HLA-DQB2 CR201_G0016218 CR201_G0016218 CR201_G0016219 CR201_G0016219 LOC100460187 LOC100460187 ENSPPYP00000019322 ENSPPYP00000019322 VPS52 VPS52 CR201_G0016218-2 CR201_G0016218-2 RAC1 RAC1 AP4M1 AP4M1 AP1S1 AP1S1 PLOD3 PLOD3 CALN1 CALN1 PLEKHA8 PLEKHA8 GSAP GSAP COG5 COG5 TAS2R16 TAS2R16 ATG9B ATG9B RGS20 RGS20 IMPAD1 IMPAD1 CLVS1 CLVS1 ARFGEF1 ARFGEF1 VPS13B VPS13B CR201_G0005484 CR201_G0005484 ST3GAL1 ST3GAL1 TRAPPC9 TRAPPC9 CLTA CLTA RGP1 RGP1 ENSPPYP00000021401 ENSPPYP00000021401 MLANA MLANA RIC1 RIC1 PCSK5 PCSK5 GCNT1 GCNT1 RAB14 RAB14 RABEPK RABEPK FUT7 FUT7 ENSPPYP00000022367 ENSPPYP00000022367 AP1S2 AP1S2 CHST7 CHST7 SLC9A7 SLC9A7 PCSK1N PCSK1N YIPF6 YIPF6 ATP7A ATP7A PIH1D3 PIH1D3 WDR44 WDR44 LAMP2 LAMP2 OCRL OCRL ATP11C ATP11C FLNA FLNA LRRK2 LRRK2 ATP11B ATP11B HLA-DPB1 HLA-DPB1 SNX9 SNX9 WDR11 WDR11 HOOK2 HOOK2 SLC11A2 SLC11A2 ATP8B2 ATP8B2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLPP3T0071805 isoform 3. (313 aa)
CNSTCNST isoform 1. (690 aa)
COG2COG2 isoform 1. (738 aa)
RAB29Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] (203 aa)
ENSPPYP00000000352annotation not available (88 aa)
LGR6LGR6 isoform 2. (892 aa)
NMNAT2Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substra [...] (399 aa)
STX6Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa)
KLHL20Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (582 aa)
VAMP4VAMP4 isoform 1. (134 aa)
TMEM79TMEM79 isoform 2. (394 aa)
SYT11SYT11 isoform 1. (388 aa)
SCAMP3Secretory carrier-associated membrane protein. (347 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (626 aa)
RAB13RAB13 isoform 2. (203 aa)
GOLPH3LGolgi phosphoprotein 3 like. (285 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
PIFOPrimary cilia formation. (191 aa)
WLSProtein wntless homolog; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). (538 aa)
YIPF1Protein YIPF1; Belongs to the YIP1 family. (306 aa)
AZIN2AZIN2 isoform 3; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (421 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
USP6NLUSP6 N-terminal like. (827 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa)
ARL5BADP ribosylation factor like GTPase 5B. (151 aa)
HTR7HTR7 isoform 3; Belongs to the G-protein coupled receptor 1 family. (459 aa)
PI4K2APhosphatidylinositol 4-kinase type 2 alpha. (479 aa)
GBF1GBF1 isoform 1. (1855 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)
CHST3Sulfotransferase; Belongs to the sulfotransferase 1 family. (479 aa)
VPS51VPS51 isoform 3. (303 aa)
MS4A7MS4A7 isoform 3. (240 aa)
CR201_G0041652MS4A6E isoform 2. (192 aa)
MS4A6AMS4A6A isoform 4. (248 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (808 aa)
CHST1Sulfotransferase; Belongs to the sulfotransferase 1 family. (417 aa)
PIK3C2APhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] (1684 aa)
DENND5ADENND5A isoform 1. (1191 aa)
ARFIP2ARFIP2 isoform 2. (342 aa)
ARAP1ARAP1 isoform 1. (1410 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
RAB38RAB38, member RAS oncogene family. (211 aa)
ENSPPYP00000004475Proprotein convertase subtilisin/kexin type 7. (183 aa)
CR201_G0006066PCSK7 isoform 3. (621 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
SORL1SORL1 isoform 1. (2118 aa)
CR201_G0036182CRACR2A isoform 1. (319 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
ENSPPYP00000004926annotation not available (398 aa)
CCDC91Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. (441 aa)
BICD1BICD1 isoform 4. (975 aa)
MARCH9MARCH9 isoform 1. (237 aa)
LGR5LGR5 isoform 1. (907 aa)
ARL1ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (247 aa)
ATXN2ATXN2 isoform 2. (1245 aa)
NBEANBEA isoform 4. (2941 aa)
POSTNPOSTN isoform 4. (836 aa)
COG6Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (657 aa)
COG3COG3 isoform 1. (742 aa)
ATP7BATP7B isoform 3. (1434 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1159 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa)
AP4S1Adaptor related protein complex 4 subunit sigma 1. (159 aa)
TRAPPC6BTrafficking protein particle complex 6B. (158 aa)
PLD4PLD4 isoform 1. (506 aa)
CLBA1Clathrin binding box of aftiphilin containing 1. (325 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa)
SLC24A5SLC24A5 isoform 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (498 aa)
ATP8B4Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1149 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1137 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa)
SCAMP2Secretory carrier-associated membrane protein. (329 aa)
SCAMP5Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity). (240 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
BAIAP3BAIAP3 isoform 3. (1072 aa)
CORO7Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). (955 aa)
COG7COG7 isoform 1. (771 aa)
CR201_G0034261GGA2 isoform 1. (451 aa)
CLN3Battenin. (438 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
C16orf70Chromosome 16 open reading frame 70. (422 aa)
CHST4Sulfotransferase; Belongs to the sulfotransferase 1 family. (386 aa)
CHST6Sulfotransferase; Belongs to the sulfotransferase 1 family. (395 aa)
CHST5Sulfotransferase; Belongs to the sulfotransferase 1 family. (411 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (946 aa)
ENSPPYP00000008720annotation not available (160 aa)
VPS53Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] (770 aa)
INPP5KINPP5K isoform 1. (446 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
STX8STX8 isoform 2. (236 aa)
LLGL1LLGL1 isoform 2. (1051 aa)
MYO18AMYO18A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2049 aa)
C17H17orf75C17orf75 isoform 2. (396 aa)
GRNGRN isoform 1. (578 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa)
CA4Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (312 aa)
CR201_G0024013WIPI1 isoform 2. (251 aa)
COG1COG1 isoform 2. (980 aa)
GGA3GGA3 isoform 1. (716 aa)
TEPSINTEPSIN isoform 1. (492 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1212 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
ATP9BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1183 aa)
SLC66A2Solute carrier family 66 member 2. (271 aa)
CR201_G0052494PCSK4 isoform 7. (546 aa)
ATP8B3Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1227 aa)
PLEKHJ1PLEKHJ1 isoform 1. (149 aa)
GPR108GPR108 isoform 1. (463 aa)
AP1M2AP1M2 isoform 1; Belongs to the adaptor complexes medium subunit family. (412 aa)
DNM2DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
YIPF2Protein YIPF. (287 aa)
STX10STX10 isoform 6; Belongs to the syntaxin family. (249 aa)
CLIP3CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa)
TRAPPC6ATRAPPC6A isoform 2. (171 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. (206 aa)
TMEM230Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa)
MMP24MMP24 isoform 1. (514 aa)
ARFGEF2ARFGEF2 isoform 1. (1779 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1022 aa)
STX16STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa)
GNASGNAS isoform 2. (1037 aa)
ARFRP1ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. (201 aa)
DOP1BDOP1 leucine zipper like protein B. (2298 aa)
BACE2BACE2 isoform 2; Belongs to the peptidase A1 family. (505 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa)
AP1B1AP complex subunit beta. (946 aa)
CABP7Calcium binding protein 7. (215 aa)
RNF215Ring finger protein 215. (377 aa)
GGA1GGA1 isoform 1. (634 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
PHETA2PH domain containing endocytic trafficking adaptor 2. (259 aa)
GCC2GCC2 isoform 3. (1686 aa)
AFTPHAFTPH isoform 3. (919 aa)
VPS54VPS54 subunit of GARP complex. (977 aa)
PREPLProlyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). (705 aa)
BIRC6BIRC6 isoform 1. (4803 aa)
YIPF4Protein YIPF. (244 aa)
SLC30A6SLC30A6 isoform 7. (412 aa)
DPY30Dpy-30 histone methyltransferase complex regulatory subunit. (99 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa)
EIPR1EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. (409 aa)
TGOLN2TGOLN2 isoform 3. (369 aa)
ARL5AADP ribosylation factor like GTPase 5A; Belongs to the small GTPase superfamily. Arf family. (179 aa)
CR201_G0050356CERKL isoform 11. (420 aa)
MARCHF4Membrane associated ring-CH-type finger 4. (410 aa)
ATG9AAutophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (838 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
ENSPPYP00000014947LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase 4-like. (133 aa)
SMPD4SMPD4 isoform 1. (848 aa)
TBC1D23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1 (By similarity). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outg [...] (699 aa)
CLASP2CLASP2 isoform 2. (1505 aa)
ATP2C1Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. (949 aa)
CHST2Sulfotransferase; Belongs to the sulfotransferase 1 family. (530 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
NSG1Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa)
LAP3Leucine aminopeptidase 3. (519 aa)
PI4K2BPI4K2B isoform 1. (481 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1164 aa)
TMEM165GDT1 family protein. (324 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (302 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (327 aa)
ARFIP1ARFIP1 isoform 2. (373 aa)
MARCHF1MARCH1 isoform 2. (542 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
SCAMP1Secretory carrier-associated membrane protein. (338 aa)
RHOBTB3RHOBTB3 isoform 7. (548 aa)
PCSK1PCSK1 isoform 1; Belongs to the peptidase S8 family. (753 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
TGFBITGFBI isoform 2. (648 aa)
CD74CD74 isoform 2. (232 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
NSG2Neuronal vesicle trafficking associated 2. (171 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
KIF13AKIF13A isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1788 aa)
HLA-DRB5Ig-like domain-containing protein. (266 aa)
CR201_G0016196HLA-DQB1 isoform 5. (304 aa)
TJAP1Tight junction associated protein 1. (558 aa)
DOP1ADOPEY1 isoform 2. (2384 aa)
FUT9Fucosyltransferase 9. (359 aa)
CLVS2CLVS2 isoform 1. (327 aa)
RAB32RAB32, member RAS oncogene family. (225 aa)
IGF2RIGF2R isoform 1. (2446 aa)
CR201_G0016191HLA-DRB5 isoform 1. (290 aa)
ENSPPYP00000019293HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
CR201_G0016218HLA-DPA1 isoform 1; Belongs to the MHC class II family. (260 aa)
CR201_G0016219HLA-DPB1 isoform 1. (283 aa)
LOC100460187MHC class II protein; Belongs to the MHC class II family. (254 aa)
ENSPPYP00000019322annotation not available (157 aa)
VPS52VPS52 isoform 4. (723 aa)
CR201_G0016218-2HLA-DPA1 isoform 3. (239 aa)
RAC1Rac family small GTPase 1. (211 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (245 aa)
PLOD3Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosy [...] (738 aa)
CALN1CALN1 isoform 1. (219 aa)
PLEKHA8Pleckstrin homology domain containing A8. (519 aa)
GSAPGamma-secretase activating protein. (854 aa)
COG5COG5 isoform 5. (859 aa)
TAS2R16Taste receptor type 2. (291 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
RGS20RGS20 isoform 1. (388 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
CLVS1Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). (354 aa)
ARFGEF1ARFGEF1 isoform 4. (1808 aa)
VPS13BVPS13B isoform 3. (3944 aa)
CR201_G0005484FAM91A1 isoform 1. (511 aa)
ST3GAL1ST3GAL1 isoform 1; Belongs to the glycosyltransferase 29 family. (340 aa)
TRAPPC9TRAPPC9 isoform 1. (1234 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
RGP1RGP1 homolog, RAB6A GEF complex partner 1. (391 aa)
ENSPPYP00000021401annotation not available (104 aa)
MLANAMLANA isoform 1. (118 aa)
RIC1RIC1 isoform 3. (1344 aa)
PCSK5PCSK5 isoform 1; Belongs to the peptidase S8 family. (1887 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell [...] (179 aa)
RABEPKRABEPK isoform 2. (363 aa)
FUT7Fucosyltransferase 7. (342 aa)
ENSPPYP00000022367annotation not available (427 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
CHST7Sulfotransferase; Belongs to the sulfotransferase 1 family. (486 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (728 aa)
PCSK1NProprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa)
YIPF6Protein YIPF. (236 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
PIH1D3PIH1 domain containing 3. (214 aa)
WDR44WDR44 isoform 2. (902 aa)
LAMP2Lysosomal associated membrane protein 2. (410 aa)
OCRLOCRL isoform 3. (855 aa)
ATP11CPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1129 aa)
FLNAFLNA isoform 7. (2647 aa)
LRRK2LRRK2 isoform 3. (1560 aa)
ATP11BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (599 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
SNX9Sorting nexin. (618 aa)
WDR11WDR11 isoform 1. (652 aa)
HOOK2Hook microtubule tethering protein 2. (719 aa)
SLC11A2SLC11A2 isoform 12. (573 aa)
ATP8B2ATP8B2 isoform 1. (1209 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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