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SLC11A2 SLC11A2 PDZK1 PDZK1 ESPN ESPN CUBN CUBN VCL VCL ADD3 ADD3 CDHR5 CDHR5 SHANK2 SHANK2 ENSPPYP00000003496 ENSPPYP00000003496 SLC22A12 SLC22A12 USH1C USH1C PDZD3 PDZD3 CR201_G0026161 CR201_G0026161 EPS8 EPS8 DNM1L DNM1L LIMA1 LIMA1 SOAT2 SOAT2 MYO1A MYO1A SLC15A1 SLC15A1 ACTN1 ACTN1 AMN AMN SLC28A2 SLC28A2 MYO1E MYO1E SLC28A1 SLC28A1 ANKS4B ANKS4B MYO1C MYO1C FLII FLII SLC46A1 SLC46A1 MYO1D MYO1D CA4 CA4 GNA13 GNA13 SLC9A3R1 SLC9A3R1 MYO15B MYO15B DCXR DCXR MYL12B MYL12B SLC7A9 SLC7A9 MYH14 MYH14 SLC19A1 SLC19A1 SLC5A1 SLC5A1 MYH9 MYH9 SLC3A1 SLC3A1 PLB1 PLB1 SLC5A6 SLC5A6 ITLN1 ITLN1 MYO7B MYO7B ACTR3 ACTR3 LRP2 LRP2 CYBRD1 CYBRD1 MYO1B MYO1B VIL1 VIL1 SLC26A6 SLC26A6 PLS1 PLS1 MME MME SI SI SLC2A2 SLC2A2 CR201_G0040852 CR201_G0040852 DRD5 DRD5 SLC34A2 SLC34A2 ABCG2 ABCG2 MTTP MTTP ENPEP ENPEP SLC7A11 SLC7A11 SLC9A3 SLC9A3 SLC6A19 SLC6A19 SLC22A5 SLC22A5 SLC23A1 SLC23A1 SLC34A1 SLC34A1 CDHR2 CDHR2 CLIC1 CLIC1 ITPR3 ITPR3 EZR EZR GNA12 GNA12 NPC1L1 NPC1L1 AQP1 AQP1 SCIN SCIN CD36 CD36 SLC26A4 SLC26A4 SLC26A3 SLC26A3 CAPZA2 CAPZA2 ATP6V0A4 ATP6V0A4 PLEC PLEC B4GALT1 B4GALT1 SLC28A3 SLC28A3 RALGDS RALGDS CR201_G0049742 CR201_G0049742 ACE2 ACE2 CLTRN CLTRN ATP7A ATP7A FLNA FLNA ENSPPYP00000023721 ENSPPYP00000023721 ENSPPYP00000023839 ENSPPYP00000023839 ACTN3 ACTN3 SLC6A18 SLC6A18
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC11A2SLC11A2 isoform 12. (573 aa)
PDZK1Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] (519 aa)
ESPNESPN isoform 1. (848 aa)
CUBNCUBN isoform 1. (3507 aa)
VCLVCL isoform 2. (1134 aa)
ADD3ADD3 isoform 3. (706 aa)
CDHR5CDHR5 isoform 1. (768 aa)
SHANK2SHANK2 isoform 6. (1266 aa)
ENSPPYP00000003496annotation not available (383 aa)
SLC22A12SLC22A12 isoform 2. (473 aa)
USH1CUSH1C isoform 9. (403 aa)
PDZD3PDZ domain containing 3. (491 aa)
CR201_G0026161USH1C isoform 8. (559 aa)
EPS8Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa)
DNM1LDNM1L isoform 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (686 aa)
LIMA1LIMA1 isoform 1. (760 aa)
SOAT2O-acyltransferase. (489 aa)
MYO1AMYO1A isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (827 aa)
SLC15A1Solute carrier family 15 member 1. (708 aa)
ACTN1ACTN1 isoform 1. (980 aa)
AMNAMN isoform 2. (446 aa)
SLC28A2Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (658 aa)
MYO1EMYO1E isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1109 aa)
SLC28A1Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (608 aa)
ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B. (417 aa)
MYO1CMYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
FLIIFLII isoform 1. (1239 aa)
SLC46A1SLC46A1 isoform 1. (459 aa)
MYO1DMYO1D isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
CA4Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (312 aa)
GNA13G protein subunit alpha 13. (377 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
MYO15BMYO15B isoform 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1560 aa)
DCXRDCXR isoform 2. (224 aa)
MYL12BMyosin light chain 12B. (172 aa)
SLC7A9Solute carrier family 7 member 9. (487 aa)
MYH14MYH14 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1889 aa)
SLC19A1SLC19A1 isoform 5. (514 aa)
SLC5A1SLC5A1 isoform 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (663 aa)
MYH9MYH9 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1959 aa)
SLC3A1SLC3A1 isoform 1. (685 aa)
PLB1PLB1 isoform 2. (1458 aa)
SLC5A6Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (636 aa)
ITLN1LOW QUALITY PROTEIN: intelectin-1. (311 aa)
MYO7BMYO7B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ACTR3Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] (418 aa)
LRP2LRP2 isoform 1. (4512 aa)
CYBRD1Cytochrome b reductase 1; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells (By similarity). (286 aa)
MYO1BMYO1B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (974 aa)
VIL1VIL1 isoform 1. (839 aa)
SLC26A6SLC26A6 isoform 1. (737 aa)
PLS1PLS1 isoform 1. (631 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
SISI isoform 1. (1776 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
CR201_G0040852MFSD10 isoform 1. (469 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (477 aa)
SLC34A2Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli (By similarity). Belongs to the SLC34A transporter family. (690 aa)
ABCG2ABCG2 isoform 2. (625 aa)
MTTPMTTP isoform 1. (892 aa)
ENPEPAminopeptidase. (957 aa)
SLC7A11Cystine/glutamate transporter; Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. (472 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (805 aa)
SLC6A19Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity. (551 aa)
SLC22A5SLC22A5 isoform 1. (557 aa)
SLC23A1SLC23A1 isoform 3. (599 aa)
SLC34A1SLC34A1 isoform 3. (616 aa)
CDHR2CDHR2 isoform 1. (778 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
ITPR3ITPR3 isoform 1. (2641 aa)
EZREZR isoform 1. (586 aa)
GNA12GNA12 isoform 1. (381 aa)
NPC1L1NPC1L1 isoform 2. (1326 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (323 aa)
SCINSCIN isoform 3. (715 aa)
CD36CD36 isoform 15; Belongs to the CD36 family. (472 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (778 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (762 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (286 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (876 aa)
PLECPLEC isoform 2. (2298 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
SLC28A3Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (692 aa)
RALGDSRALGDS isoform 4. (912 aa)
CR201_G0049742SLC34A3 isoform 1. (395 aa)
ACE2Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] (802 aa)
CLTRNTMEM27 isoform 1. (247 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
FLNAFLNA isoform 7. (2647 aa)
ENSPPYP00000023721annotation not available (169 aa)
ENSPPYP00000023839annotation not available (519 aa)
ACTN3Actinin alpha 2/3. (388 aa)
SLC6A18Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (635 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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