STRINGSTRING
FER1L5 FER1L5 STX16 STX16 CHMP4B CHMP4B VPS16 VPS16 CHMP2A CHMP2A VPS39 VPS39 SNAP23 SNAP23 SPG11 SPG11 VPS33B VPS33B CLN3 CLN3 CORO1A CORO1A PRRT2 PRRT2 STX1B STX1B STX4 STX4 VPS4A VPS4A TRARG1 TRARG1 ANKFY1 ANKFY1 VAMP2 VAMP2 STX8 STX8 RAB34 RAB34 GOSR2 GOSR2 PLEKHM1 PLEKHM1 CR201_G0023764 CR201_G0023764 SYT4 SYT4 STX10 STX10 ENSPPYP00000011173 ENSPPYP00000011173 CLTRN CLTRN ATP13A2 ATP13A2 BET1 BET1 PIP4K2B PIP4K2B SNAP47 SNAP47 STX6 STX6 VAMP4 VAMP4 SYT11 SYT11 RAB13 RAB13 SNAPIN SNAPIN PLA2G5 PLA2G5 VAV3 VAV3 VAMP7 VAMP7 VAMP3 VAMP3 PIP4K2A PIP4K2A VTI1A VTI1A STX5 STX5 SYT7 SYT7 STX3 STX3 UVRAG UVRAG RAB39A RAB39A VPS11 VPS11 VAMP1 VAMP1 VPS33A VPS33A STX2 STX2 LRMP LRMP CR201_G0016717 CR201_G0016717 RAB20 RAB20 CHMP4A CHMP4A STXBP6 STXBP6 VTI1B VTI1B VIPAS39 VIPAS39 VPS18 VPS18 STX17 STX17 TSNARE1 TSNARE1 CHMP4C CHMP4C CAV2 CAV2 SAMD9 SAMD9 SAMD9L SAMD9L VPS41 VPS41 STX11 STX11 NKD2 NKD2 USO1 USO1 TMEM175 TMEM175 VPS8 VPS8 ARL8B ARL8B RAB7A RAB7A PIKFYVE PIKFYVE YIPF4 YIPF4 DYSF DYSF TGFBRAP1 TGFBRAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FER1L5FER1L5 isoform 6. (801 aa)
STX16STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa)
CHMP4BCHMP4B isoform 1. (210 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
CHMP2ACHMP2A isoform 1. (222 aa)
VPS39VPS39 isoform 1. (875 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
SPG11SPG11 isoform 3. (2431 aa)
VPS33BVPS33B isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
CLN3Battenin. (438 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (445 aa)
PRRT2Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. (340 aa)
STX1BSTX1B isoform 1; Belongs to the syntaxin family. (590 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
VPS4AVPS4A isoform 1; Belongs to the AAA ATPase family. (437 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1170 aa)
VAMP2VAMP2 isoform 2. (116 aa)
STX8STX8 isoform 2. (236 aa)
RAB34RAB34 isoform 8. (251 aa)
GOSR2T0082108 isoform 1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa)
PLEKHM1PLEKHM1 isoform 1. (564 aa)
CR201_G0023764PLEKHM1 isoform 4. (241 aa)
SYT4SYT4 isoform 1. (425 aa)
STX10STX10 isoform 6; Belongs to the syntaxin family. (249 aa)
ENSPPYP00000011173annotation not available (222 aa)
CLTRNTMEM27 isoform 1. (247 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1175 aa)
BET1BET1 isoform 1. (99 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (435 aa)
SNAP47SNAP47 isoform 1. (459 aa)
STX6Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa)
VAMP4VAMP4 isoform 1. (134 aa)
SYT11SYT11 isoform 1. (388 aa)
RAB13RAB13 isoform 2. (203 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
PLA2G5Phospholipase A(2). (138 aa)
VAV3VAV3 isoform 1. (824 aa)
VAMP7Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (220 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (347 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)
STX5STX5 isoform 1; Belongs to the syntaxin family. (355 aa)
SYT7SYT7 isoform 1. (400 aa)
STX3STX3 isoform 3; Belongs to the syntaxin family. (289 aa)
UVRAGUV radiation resistance associated. (699 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
VAMP1Vesicle associated membrane protein 1. (118 aa)
VPS33AT0002578 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
STX2STX2 isoform 2; Belongs to the syntaxin family. (263 aa)
LRMPLRMP isoform 1. (496 aa)
CR201_G0016717RUBCNL isoform 6. (570 aa)
RAB20RAB20, member RAS oncogene family. (234 aa)
CHMP4ACHMP4A isoform 4. (258 aa)
STXBP6STXBP6 isoform 1. (179 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
VIPAS39VIPAS39 isoform 6. (433 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
STX17STX17 isoform 1; Belongs to the syntaxin family. (302 aa)
TSNARE1TSNARE1 isoform 1. (511 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
SAMD9SAMD9 isoform 1. (1588 aa)
SAMD9LSAMD9L isoform 2. (1584 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
STX11STX11 isoform 1; Belongs to the syntaxin family. (287 aa)
NKD2NKD2 isoform 1. (455 aa)
USO1USO1 isoform 2. (969 aa)
TMEM175TMEM175 isoform 4. (229 aa)
VPS8VPS8 isoform 6. (1428 aa)
ARL8BADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). (185 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa)
PIKFYVEPIKFYVE isoform 1. (2088 aa)
YIPF4Protein YIPF. (244 aa)
DYSFDYSF isoform 11. (1710 aa)
TGFBRAP1TGFBRAP1 isoform 1. (860 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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