STRINGSTRING
STK25 STK25 ENSPPYP00000024064 ENSPPYP00000024064 PDCD10 PDCD10 BET1 BET1 TMED2 TMED2 VRK1 VRK1 GOLGA8A GOLGA8A NPLOC4 NPLOC4 CR201_G0055953 CR201_G0055953 ATP8B2 ATP8B2 FHDC1 FHDC1 LRRK2 LRRK2 TMED9 TMED9 HUWE1 HUWE1 ENSPPYP00000022422 ENSPPYP00000022422 ENSPPYP00000022420 ENSPPYP00000022420 SEC16A SEC16A SURF4 SURF4 GOLGA2 GOLGA2 STX17 STX17 ENSPPYP00000021401 ENSPPYP00000021401 VPS13B VPS13B ARFGEF1 ARFGEF1 VCPIP1 VCPIP1 RAB2A RAB2A UBXN2B UBXN2B COG5 COG5 TMED4 TMED4 BHLHA15 BHLHA15 SYNE1 SYNE1 HACE1 HACE1 TJAP1 TJAP1 CUL7 CUL7 ENSPPYP00000018069 ENSPPYP00000018069 LMAN2 LMAN2 FAM71B FAM71B LYSMD3 LYSMD3 GOLPH3 GOLPH3 TRAPPC11 TRAPPC11 USO1 USO1 PI4K2B PI4K2B HTT HTT ENSPPYP00000016227 ENSPPYP00000016227 GAK GAK RAB6B RAB6B CLASP2 CLASP2 GORASP1 GORASP1 ZNF501 ZNF501 GORASP2 GORASP2 CLASP1 CLASP1 TRAPPC12 TRAPPC12 UBXN2A UBXN2A YIPF4 YIPF4 ATL2 ATL2 RAB1A RAB1A GCC2 GCC2 TTC38 TTC38 TANGO2 TANGO2 DNAJC28 DNAJC28 STX16 STX16 TBC1D20 TBC1D20 NSFL1C NSFL1C SMIM7 SMIM7 RAB8A RAB8A ATP8B3 ATP8B3 PLK5 PLK5 ATP8B1 ATP8B1 DYM DYM BCAS3 BCAS3 COG1 COG1 ENSPPYP00000009562 ENSPPYP00000009562 MYO18A MYO18A TMED6 TMED6 KIFC3 KIFC3 ENSPPYP00000008251 ENSPPYP00000008251 COG7 COG7 FAM174B FAM174B ENSPPYP00000007784 ENSPPYP00000007784 CR201_G0055098 CR201_G0055098 LOC100443202 LOC100443202 CR201_G0014967 CR201_G0014967 CR201_G0056481-2 CR201_G0056481-2 CR201_G0050725 CR201_G0050725 ENSPPYP00000007764 ENSPPYP00000007764 CR201_G0056251 CR201_G0056251 ENSPPYP00000007759 ENSPPYP00000007759 CR201_G0051405 CR201_G0051405 LYSMD4 LYSMD4 CR201_G0043294 CR201_G0043294 TMED3 TMED3 ENSPPYP00000007564 ENSPPYP00000007564 LMAN1L LMAN1L ENSPPYP00000007506 ENSPPYP00000007506 LYSMD2 LYSMD2 ATP8B4 ATP8B4 SPTBN5 SPTBN5 ENSPPYP00000007156 ENSPPYP00000007156 ENSPPYP00000007137 ENSPPYP00000007137 CR201_G0056473 CR201_G0056473 CR201_G0056275 CR201_G0056275 ENSPPYP00000007090 ENSPPYP00000007090 BAG5 BAG5 GOLGA5 GOLGA5 TRIP11 TRIP11 VTI1B VTI1B PRKD1 PRKD1 PRMT5 PRMT5 RAB2B RAB2B ARHGEF7 ARHGEF7 COG3 COG3 COG6 COG6 CIT CIT FBXW8 FBXW8 ARL1 ARL1 FAM71C FAM71C ZW10 ZW10 CR201_G0025506 CR201_G0025506 ENSPPYP00000004367 ENSPPYP00000004367 DYNC2H1 DYNC2H1 HIKESHI HIKESHI RAB30 RAB30 STX5 STX5 ATL3 ATL3 VPS51 VPS51 RAB1B RAB1B SEC23IP SEC23IP VTI1A VTI1A GBF1 GBF1 PI4K2A PI4K2A CDK1 CDK1 ARHGAP21 ARHGAP21 OPTN OPTN HOOK1 HOOK1 USP6NL USP6NL CR201_G0041907 CR201_G0041907 ZFP69B ZFP69B CDC42 CDC42 PLEKHM2 PLEKHM2 COG2 COG2 RAB29 RAB29 STX6 STX6 SEC16B SEC16B VAMP4 VAMP4 BLZF1 BLZF1 GOLPH3L GOLPH3L TMED5 TMED5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STK25Serine/threonine kinase 25. (435 aa)
ENSPPYP00000024064annotation not available (287 aa)
PDCD10PDCD10 isoform 1. (186 aa)
BET1BET1 isoform 1. (99 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
VRK1VRK1 isoform 2; Belongs to the protein kinase superfamily. (335 aa)
GOLGA8AGolgin subfamily A member 8A isoform X1. (69 aa)
NPLOC4NPLOC4 isoform 1. (609 aa)
CR201_G0055953GOLGA6L1 isoform 1. (392 aa)
ATP8B2ATP8B2 isoform 1. (1209 aa)
FHDC1FH2 domain containing 1. (1150 aa)
LRRK2LRRK2 isoform 3. (1560 aa)
TMED9Transmembrane p24 trafficking protein 9. (235 aa)
HUWE1HUWE1 isoform 1. (4373 aa)
ENSPPYP00000022422annotation not available (126 aa)
ENSPPYP00000022420annotation not available (560 aa)
SEC16AProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2328 aa)
SURF4Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. (254 aa)
GOLGA2GOLGA2 isoform 2. (1033 aa)
STX17STX17 isoform 1; Belongs to the syntaxin family. (302 aa)
ENSPPYP00000021401annotation not available (104 aa)
VPS13BVPS13B isoform 3. (3944 aa)
ARFGEF1ARFGEF1 isoform 4. (1808 aa)
VCPIP1VCPIP1 isoform 1. (1224 aa)
RAB2ARas-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. (212 aa)
UBXN2BUBX domain protein 2B. (331 aa)
COG5COG5 isoform 5. (859 aa)
TMED4Transmembrane p24 trafficking protein 4. (227 aa)
BHLHA15Basic helix-loop-helix family member a15. (190 aa)
SYNE1SYNE1 isoform 1. (8465 aa)
HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (909 aa)
TJAP1Tight junction associated protein 1. (558 aa)
CUL7Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] (1723 aa)
ENSPPYP00000018069LOW QUALITY PROTEIN: golgin subfamily A member 6-like protein 2. (115 aa)
LMAN2Lectin, mannose binding 2. (356 aa)
FAM71BFAM71B isoform 1. (605 aa)
LYSMD3LysM domain containing 3. (306 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
TRAPPC11TRAPPC11 isoform 2. (1133 aa)
USO1USO1 isoform 2. (969 aa)
PI4K2BPI4K2B isoform 1. (481 aa)
HTTHTT isoform 1. (3130 aa)
ENSPPYP00000016227annotation not available (190 aa)
GAKGAK isoform 7. (1062 aa)
RAB6BRAB6B, member RAS oncogene family. (208 aa)
CLASP2CLASP2 isoform 2. (1505 aa)
GORASP1GORASP1 isoform 1. (444 aa)
ZNF501Zinc finger protein 501; May be involved in transcriptional regulation (By similarity). Essential for Golgi structural integrity (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family. (271 aa)
GORASP2GORASP2 isoform 1. (410 aa)
CLASP1CLASP1 isoform 3. (1537 aa)
TRAPPC12Trafficking protein particle complex 12. (736 aa)
UBXN2AUBXN2A isoform 2. (261 aa)
YIPF4Protein YIPF. (244 aa)
ATL2Atlastin GTPase 2. (583 aa)
RAB1ARAB1A isoform 1. (205 aa)
GCC2GCC2 isoform 3. (1686 aa)
TTC38Tetratricopeptide repeat protein 38; Belongs to the TTC38 family. (469 aa)
TANGO2Transport and golgi organization 2 homolog. (276 aa)
DNAJC28DnaJ heat shock protein family (Hsp40) member C28. (387 aa)
STX16STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
NSFL1CNSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (370 aa)
SMIM7T0132324 isoform 5. (75 aa)
RAB8ARas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
ATP8B3Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1227 aa)
PLK5Serine/threonine-protein kinase PLK. (449 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1212 aa)
DYMDymeclin; Necessary for correct organization of Golgi apparatus. Involved in bone development; Belongs to the dymeclin family. (669 aa)
BCAS3BCAS3 isoform 8. (841 aa)
COG1COG1 isoform 2. (980 aa)
ENSPPYP00000009562annotation not available (399 aa)
MYO18AMYO18A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2049 aa)
TMED6Transmembrane emp24 domain-containing protein 6. (240 aa)
KIFC3Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (833 aa)
ENSPPYP00000008251annotation not available (212 aa)
COG7COG7 isoform 1. (771 aa)
FAM174BFAM174B isoform 1. (162 aa)
ENSPPYP00000007784annotation not available (131 aa)
CR201_G0055098GOLGA6L6 isoform 1. (403 aa)
LOC100443202GOLGA6D isoform 1. (686 aa)
CR201_G0014967GOLGA8N isoform 2. (361 aa)
CR201_G0056481-2GOLGA6L22 isoform 2. (564 aa)
CR201_G0050725Uncharacterized protein. (423 aa)
ENSPPYP00000007764annotation not available (72 aa)
CR201_G0056251GOLGA8Q isoform 1. (430 aa)
ENSPPYP00000007759annotation not available (261 aa)
CR201_G0051405GOLGA8H isoform 1. (739 aa)
LYSMD4LysM and putative peptidoglycan-binding domain-containing protein 4. (326 aa)
CR201_G0043294T0153360 isoform 1. (86 aa)
TMED3Transmembrane p24 trafficking protein 3. (217 aa)
ENSPPYP00000007564annotation not available (279 aa)
LMAN1LLMAN1L isoform 2. (468 aa)
ENSPPYP00000007506annotation not available (522 aa)
LYSMD2LYSMD2 isoform 2. (124 aa)
ATP8B4Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1149 aa)
SPTBN5SPTBN5 isoform 1. (3674 aa)
ENSPPYP00000007156annotation not available (496 aa)
ENSPPYP00000007137annotation not available (195 aa)
CR201_G0056473GOLGA8R isoform 1. (576 aa)
CR201_G0056275Uncharacterized protein. (396 aa)
ENSPPYP00000007090annotation not available (597 aa)
BAG5BCL2 associated athanogene 5. (447 aa)
GOLGA5GOLGA5 isoform 1. (731 aa)
TRIP11TRIP11 isoform 2. (1979 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine resi [...] (637 aa)
RAB2BRAB2B isoform 1. (216 aa)
ARHGEF7ARHGEF7 isoform 7. (803 aa)
COG3COG3 isoform 1. (742 aa)
COG6Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (657 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2054 aa)
FBXW8FBXW8 isoform 2. (596 aa)
ARL1ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
FAM71CFamily with sequence similarity 71 member C. (241 aa)
ZW10Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (By similarity). (779 aa)
CR201_G0025506DYNC2H1 isoform 3. (1794 aa)
ENSPPYP00000004367annotation not available (644 aa)
DYNC2H1DYNC2H1 isoform 2. (987 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
STX5STX5 isoform 1; Belongs to the syntaxin family. (355 aa)
ATL3ATL3 isoform 1. (568 aa)
VPS51VPS51 isoform 3. (303 aa)
RAB1BRas-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates [...] (199 aa)
SEC23IPSEC23IP isoform 1. (1018 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)
GBF1GBF1 isoform 1. (1855 aa)
PI4K2APhosphatidylinositol 4-kinase type 2 alpha. (479 aa)
CDK1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] (297 aa)
ARHGAP21ARHGAP21 isoform 2. (1957 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa)
HOOK1Hook microtubule tethering protein 1. (728 aa)
USP6NLUSP6 N-terminal like. (827 aa)
CR201_G0041907Serine/threonine-protein kinase PLK. (286 aa)
ZFP69BZFP69B isoform 3. (400 aa)
CDC42Cell division cycle 42. (191 aa)
PLEKHM2PLEKHM2 isoform 1. (953 aa)
COG2COG2 isoform 1. (738 aa)
RAB29Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] (203 aa)
STX6Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa)
SEC16BProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (950 aa)
VAMP4VAMP4 isoform 1. (134 aa)
BLZF1BLZF1 isoform 1. (397 aa)
GOLPH3LGolgi phosphoprotein 3 like. (285 aa)
TMED5Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity). (278 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (20%) [HD]