50 items (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAC2	Rac family small GTPase 2. (192 aa)
	SELE	SELE isoform 3. (601 aa)
	PTPRC	PTPRC isoform 2. (1267 aa)
	ITGB2	Integrin beta. (768 aa)
	SELL	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa)
	ZAP70	Tyrosine-protein kinase. (559 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	ADD2	Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. (726 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
	PODXL2	PODXL2 isoform 1. (523 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	SLC39A8	SLC39A8 isoform 4. (424 aa)
	GOLPH3	Golgi phosphoprotein 3. (298 aa)
	TNIP1	TNIP1 isoform 10. (583 aa)
	STK10	STK10 isoform 1. (968 aa)
	TNF	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
	EZR	EZR isoform 1. (586 aa)
	EXT1	Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
	GCNT1	Glucosaminyl (N-acetyl) transferase 1. (428 aa)
	SEMA4D	SEMA4D isoform 10; Belongs to the semaphorin family. (862 aa)
	SYK	Tyrosine-protein kinase. (588 aa)
	CERCAM	CERCAM isoform 3. (528 aa)
	MSN	MSN isoform 6. (577 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	CALCA	Calcitonin related polypeptide alpha. (142 aa)
	JAM2	Junctional adhesion molecule 2. (298 aa)
	APOA4	Apolipoprotein A4. (416 aa)
	OLR1	Oxidized low density lipoprotein receptor 1. (273 aa)
	BMP7	Bone morphogenetic protein 7. (365 aa)
	ENSPPYP00000011254	CD177 antigen. (166 aa)
	CD177	CD177 isoform 1. (437 aa)
	LRG1	Leucine-rich alpha-2-glycoprotein. (383 aa)
	MADCAM1	MADCAM1 isoform 4. (345 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1299 aa)
	PECAM1	PECAM1 isoform 1. (738 aa)
	CCL5	C-C motif chemokine. (91 aa)
	ITGAL	ITGAL isoform 1; Belongs to the integrin alpha chain family. (1131 aa)
	SPN	SPN isoform 1. (400 aa)
	UMOD	Uromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. (641 aa)
	SELPLG	SELPLG isoform 1. (402 aa)
	ITGA5	ITGA5 isoform 1; Belongs to the integrin alpha chain family. (1078 aa)
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (797 aa)
	CR201_G0011084	CD44 isoform 1. (351 aa)
	FERMT3	FERMT3 isoform 2. (694 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (114 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (93 aa)
	F11R	F11R isoform 1. (298 aa)
	SELP	SELP isoform 2. (829 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD2	ROCK1	ENSPPYP00000013740	ENSPPYP00000010161	Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.427
APOA4	LRG1	ENSPPYP00000024275	ENSPPYP00000010552	Apolipoprotein A4.	Leucine-rich alpha-2-glycoprotein.	0.457
BMP7	CR201_G0011084	ENSPPYP00000012465	ENSPPYP00000003856	Bone morphogenetic protein 7.	CD44 isoform 1.	0.461
CCL5	CD40LG	ENSPPYP00000009214	ENSPPYP00000023252	C-C motif chemokine.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.574
CCL5	CR201_G0011084	ENSPPYP00000009214	ENSPPYP00000003856	C-C motif chemokine.	CD44 isoform 1.	0.631
CCL5	CX3CR1	ENSPPYP00000009214	ENSPPYP00000015654	C-C motif chemokine.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.893
CCL5	IL1B	ENSPPYP00000009214	ENSPPYP00000013573	C-C motif chemokine.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.741
CCL5	ITGAL	ENSPPYP00000009214	ENSPPYP00000008221	C-C motif chemokine.	ITGAL isoform 1; Belongs to the integrin alpha chain family.	0.446
CCL5	ITGB2	ENSPPYP00000009214	ENSPPYP00000012844	C-C motif chemokine.	Integrin beta.	0.559
CCL5	PECAM1	ENSPPYP00000009214	ENSPPYP00000009599	C-C motif chemokine.	PECAM1 isoform 1.	0.420
CCL5	PTPRC	ENSPPYP00000009214	ENSPPYP00000000426	C-C motif chemokine.	PTPRC isoform 2.	0.531
CCL5	SELE	ENSPPYP00000009214	ENSPPYP00000000612	C-C motif chemokine.	SELE isoform 3.	0.572
CCL5	SELL	ENSPPYP00000009214	ENSPPYP00000000614	C-C motif chemokine.	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.	0.465
CCL5	SELP	ENSPPYP00000009214	ENSPPYP00000000616	C-C motif chemokine.	SELP isoform 2.	0.579
CCL5	SELPLG	ENSPPYP00000009214	ENSPPYP00000005614	C-C motif chemokine.	SELPLG isoform 1.	0.517
CCL5	TNF	ENSPPYP00000009214	ENSPPYP00000018379	C-C motif chemokine.	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family.	0.750
CCL5	VCAM1	ENSPPYP00000009214	ENSPPYP00000001290	C-C motif chemokine.	Vascular cell adhesion molecule 1.	0.561
CD177	PECAM1	ENSPPYP00000011253	ENSPPYP00000009599	CD177 isoform 1.	PECAM1 isoform 1.	0.980
CD40LG	CCL5	ENSPPYP00000023252	ENSPPYP00000009214	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	C-C motif chemokine.	0.574
CD40LG	CR201_G0011084	ENSPPYP00000023252	ENSPPYP00000003856	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD44 isoform 1.	0.587