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| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | DISC1 | DISC1 scaffold protein. (840 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa) |
| | TNR | TNR isoform 1. (1309 aa) |
| | CRABP2 | Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa) |
| | IQGAP3 | IQGAP3 isoform 2. (1594 aa) |
| | SEMA4A | SEMA4A isoform 10; Belongs to the semaphorin family. (709 aa) |
| | TRIM46 | Tripartite motif containing 46. (759 aa) |
| | SEMA6C | SEMA6C isoform 1; Belongs to the semaphorin family. (932 aa) |
| | NGF | NGF isoform 1; Belongs to the NGF-beta family. (294 aa) |
| | LAMTOR5 | LAMTOR5 isoform 1. (182 aa) |
| | VAV3 | VAV3 isoform 1. (824 aa) |
| | BARHL2 | BarH like homeobox 2. (387 aa) |
| | LPAR3 | Lysophosphatidic acid receptor 3. (344 aa) |
| | MACF1 | Microtubule actin crosslinking factor 1. (5430 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa) |
| | CLCN6 | CLCN6 isoform 2; Belongs to the chloride channel (TC 2.A.49) family. (824 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (350 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa) |
| | CXCL12 | CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa) |
| | CR201_G0030157 | KCNMA1 isoform 84. (265 aa) |
| | PTEN | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | SLIT1 | Slit guidance ligand 1. (1578 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] (480 aa) |
| | SEMA4G | SEMA4G isoform 7; Belongs to the semaphorin family. (811 aa) |
| | SHTN1 | Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] (647 aa) |
| | SCT | SCT isoform 1. (83 aa) |
| | CTTN | CTTN isoform 1. (508 aa) |
| | BDNF | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa) |
| | AQP11 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa) |
| | CLNS1A | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] (237 aa) |
| | TMEM123 | TMEM123 isoform 1. (163 aa) |
| | RDX | RDX isoform 3. (604 aa) |
| | GNB3 | G protein subunit beta 3. (340 aa) |
| | ANO6 | Anoctamin. (860 aa) |
| | DIP2B | Disco interacting protein 2 homolog B. (1576 aa) |
| | RARG | RARG isoform 5. (469 aa) |
| | TRPV4 | TRPV4 isoform 2; Belongs to the transient receptor (TC 1.A.4) family. (699 aa) |
| | CR201_G0000874 | P2RX7 isoform 7. (101 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | ULK1 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa) |
| | RNF6 | RNF6 isoform 2. (685 aa) |
| | SPART | SPART isoform 1. (666 aa) |
| | ARHGAP5 | ARHGAP5 isoform 3. (1502 aa) |
| | CYFIP1 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa) |
| | SLC12A6 | SLC12A6 isoform 1. (1099 aa) |
| | SLC12A1 | SLC12A1 isoform 4. (1131 aa) |
| | SEMA7A | SEMA7A isoform 1; Belongs to the semaphorin family. (664 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | SEMA4B | SEMA4B isoform 4. (930 aa) |
| | CLN3 | Battenin. (438 aa) |
| | MT3 | Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa) |
| | SLC12A3 | SLC12A3 isoform 2. (1035 aa) |
| | E2F4 | E2F transcription factor 4. (411 aa) |
| | SLC12A4 | SLC12A4 isoform 2. (1085 aa) |
| | RAP1GAP2 | RAP1GAP2 isoform 4. (739 aa) |
| | CR201_G0035363 | NTN1 isoform 1. (337 aa) |
| | TRPV2 | Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | MAPT | Microtubule-associated protein. (759 aa) |
| | RND2 | RND2 isoform 1. (193 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa) |
| | ULK2 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1028 aa) |
| | AQP4 | AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa) |
| | DCC | DCC isoform 2. (1419 aa) |
| | SEMA6B | SEMA6B isoform 1; Belongs to the semaphorin family. (876 aa) |
| | PTPRS | PTPRS isoform 2. (1616 aa) |
| | VAV1 | VAV1 isoform 2. (829 aa) |
| | LRRC8E | Leucine rich repeat containing 8 VRAC subunit E. (796 aa) |
| | DNM2 | DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa) |
| | MAG | MAG isoform 1. (627 aa) |
| | KCNN4 | KCNN4 isoform 3. (374 aa) |
| | ARHGAP35 | Rho GTPase activating protein 35. (1513 aa) |
| | AKT1S1 | AKT1S1 isoform 1. (256 aa) |
| | SLC12A5 | Solute carrier family 12 member 5. (1116 aa) |
| | ADNP | Activity dependent neuroprotector homeobox. (1102 aa) |
| | CDH4 | CDH4 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (862 aa) |
| | DSCAM | DSCAM isoform 1. (1997 aa) |
| | RTN4R | RTN4R isoform 1. (535 aa) |
| | SHANK3 | SHANK3 isoform 2. (1202 aa) |
| | TTL | Tubulin tyrosine ligase. (377 aa) |
| | CR201_G0002974 | SEMA4F isoform 2; Belongs to the semaphorin family. (585 aa) |
| | PLEK | PLEK isoform 1. (350 aa) |
| | BCL11A | BAF chromatin remodeling complex subunit BCL11A. (773 aa) |
| | RTN4 | Reticulon. (1192 aa) |
| | UCN | UCN isoform 1. (129 aa) |
| | SEMA4C | SEMA4C isoform 1; Belongs to the semaphorin family. (746 aa) |
| | SCTR | SCTR isoform 3; Belongs to the G-protein coupled receptor 2 family. (415 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | ENSPPYP00000014638 | annotation not available (242 aa) |
| | CREB1 | CREB1 isoform 1. (341 aa) |
| | MAP2 | Microtubule-associated protein. (1770 aa) |
| | FN1 | FN1 isoform 4. (2445 aa) |
| | SEMA5B | SEMA5B isoform 1. (1091 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa) |
| | SEMA3G | SEMA3G isoform 1; Belongs to the semaphorin family. (878 aa) |
| | TWF2 | Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. (349 aa) |
| | IFRD2 | IFRD2 isoform 1. (607 aa) |
| | SEMA3B | SEMA3B isoform 6; Belongs to the semaphorin family. (690 aa) |
| | SEMA3F | SEMA3F isoform 4; Belongs to the semaphorin family. (755 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa) |
| | CCDC51 | CCDC51 isoform 2. (411 aa) |
| | GOLGA4 | GOLGA4 isoform 1. (1931 aa) |
| | CLASP2 | CLASP2 isoform 2. (1505 aa) |
| | RYK | RYK isoform 3. (535 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). (965 aa) |
| | RUFY3 | Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. (620 aa) |
| | NKX6-1 | NKX6-1 isoform 2. (367 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | SPP1 | SPP1 isoform 6. (136 aa) |
| | SLC12A7 | SLC12A7 isoform 1. (942 aa) |
| | SEMA5A | SEMA5A isoform 1. (1044 aa) |
| | IL7R | IL7R isoform 1. (459 aa) |
| | CR201_G0016076 | MAP1B isoform 1. (1431 aa) |
| | EFNA5 | EFNA5 isoform 1; Belongs to the ephrin family. (228 aa) |
| | WDR36 | WD repeat domain 36. (895 aa) |
| | SEMA6A | SEMA6A isoform 1; Belongs to the semaphorin family. (1030 aa) |
| | PRR16 | PRR16 isoform 2. (251 aa) |
| | SLC12A2 | Solute carrier family 12 member 2. (1209 aa) |
| | FSTL4 | FSTL4 isoform 1. (792 aa) |
| | CDKL3 | CDKL3 isoform 6. (545 aa) |
| | NPM1 | NPM1 isoform 1. (274 aa) |
| | DBN1 | DBN1 isoform 4. (632 aa) |
| | EDN1 | EDN1 isoform 1. (212 aa) |
| | KIAA0319 | KIAA0319 isoform 5. (1072 aa) |
| | SRF | Serum response factor. (508 aa) |
| | EPHA7 | EPHA7 isoform 1. (998 aa) |
| | OCM | OCM isoform 1; Belongs to the parvalbumin family. (109 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | LAMTOR4 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). (99 aa) |
| | SLC12A9 | SLC12A9 isoform 1. (769 aa) |
| | LIMK1 | LIMK1 isoform 2. (468 aa) |
| | ENSPPYP00000019672 | annotation not available (240 aa) |
| | DBNL | DBNL isoform 9. (430 aa) |
| | AQP1 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (323 aa) |
| | SEMA3D | SEMA3D isoform 1; Belongs to the semaphorin family. (777 aa) |
| | SEMA3A | SEMA3A isoform 1; Belongs to the semaphorin family. (771 aa) |
| | SEMA3E | SEMA3E isoform 1; Belongs to the semaphorin family. (504 aa) |
| | SLC26A5 | Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (722 aa) |
| | NRCAM | NRCAM isoform 11. (1253 aa) |
| | ENSPPYP00000020088 | annotation not available (138 aa) |
| | PLXNA4 | PLXNA4 isoform 2. (1894 aa) |
| | MTPN | MTPN isoform 2. (118 aa) |
| | KEL | KEL isoform 1. (731 aa) |
| | ENSPPYP00000020360 | annotation not available (272 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | ENSPPYP00000020473 | annotation not available (129 aa) |
| | DPYSL2 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. (572 aa) |
| | RB1CC1 | RB1CC1 isoform 1. (1594 aa) |
| | ENSPPYP00000020880 | annotation not available (223 aa) |
| | ENSPPYP00000021091 | annotation not available (270 aa) |
| | DEPTOR | DEPTOR isoform 1. (408 aa) |
| | SEMA4D | SEMA4D isoform 10; Belongs to the semaphorin family. (862 aa) |
| | LRRC8A | Leucine rich repeat containing 8 VRAC subunit A. (810 aa) |
| | CR201_G0027499 | ABL1 isoform 3. (48 aa) |
| | TSC1 | TSC1 isoform 8. (1157 aa) |
| | CR201_G0027422 | VAV2 isoform 3. (772 aa) |
| | CR201_G0027392 | OLFM1 isoform 6. (357 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | ABL1 | Tyrosine-protein kinase. (948 aa) |
| | CDKL5 | CDKL5 isoform 1. (1007 aa) |
| | ENSPPYP00000022712 | annotation not available (241 aa) |
| | WNK3 | WNK3 isoform 2. (1777 aa) |
| | MSN | MSN isoform 6. (577 aa) |
| | ATP7A | ATPase copper transporting alpha. (1500 aa) |
| | TRPC5 | Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa) |
| | AMOT | AMOT isoform 3. (1088 aa) |
| | FGF13 | Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa) |
| | L1CAM | L1 cell adhesion molecule. (1257 aa) |
| | ARHGAP4 | ARHGAP4 isoform 5. (897 aa) |
| | PLXNA3 | PLXNA3 isoform 1. (1752 aa) |
| | IFRD1 | IFRD1 isoform 4. (405 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (677 aa) |
| | RPTOR | RPTOR isoform 4. (708 aa) |
