STRINGSTRING
MARK1 MARK1 TGFB2 TGFB2 ADIPOR1 ADIPOR1 EFNA1 EFNA1 CR201_G0015745 CR201_G0015745 PDPN PDPN MAD2L2 MAD2L2 GATA3 GATA3 BAMBI BAMBI PTEN PTEN CR201_G0012836 CR201_G0012836 SDHAF2 SDHAF2 PHLDB1 PHLDB1 BCL9L BCL9L PAWR PAWR ALX1 ALX1 TBX5 TBX5 NKX2-1 NKX2-1 FOXA1 FOXA1 FERMT2 FERMT2 BMP4 BMP4 TGFB3 TGFB3 GREM1 GREM1 ELL3 ELL3 SMAD3 SMAD3 VASN VASN EMP2 EMP2 TGFB1I1 TGFB1I1 NOG NOG AXIN2 AXIN2 ZNF750 ZNF750 COL1A1 COL1A1 LDLRAD4 LDLRAD4 SMAD2 SMAD2 SMAD7 SMAD7 SMAD4 SMAD4 LOC100441148 LOC100441148 LRG1 LRG1 HPN HPN SPRED3 SPRED3 TGFB1 TGFB1 DACT3 DACT3 FUZ FUZ JAG1 JAG1 CR201_G0019832 CR201_G0019832 SNAI1 SNAI1 BMP7 BMP7 TIAM1 TIAM1 POFUT2 POFUT2 IL1B IL1B LOC100438930 LOC100438930 LOXL3 LOXL3 SPRED2 SPRED2 CLASP1 CLASP1 ACVR1 ACVR1 EPHA4 EPHA4 USF3 USF3 PHLDB2 PHLDB2 EPHA3 EPHA3 IL17RD IL17RD CTNNB1 CTNNB1 CLASP2 CLASP2 TGFBR2 TGFBR2 WWTR1 WWTR1 LEF1 LEF1 SPRY1 SPRY1 SFRP2 SFRP2 DAB2 DAB2 ISL1 ISL1 FOXC1 FOXC1 GCNT2 GCNT2 BMP5 BMP5 ENSPPYP00000018739 ENSPPYP00000018739 HDAC2 HDAC2 TBX20 TBX20 IL6 IL6 TWIST1 TWIST1 ZNF703 ZNF703 CR201_G0033322 CR201_G0033322 SDCBP SDCBP GLIPR2 GLIPR2 TGFBR1 TGFBR1 DAB2IP DAB2IP CRB2 CRB2 ENG ENG CR201_G0027392 CR201_G0027392 NOTCH1 NOTCH1 EZH2 EZH2 BMP2 BMP2 LOXL2 LOXL2 MCRIP1 MCRIP1 OVOL2 OVOL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MARK1Non-specific serine/threonine protein kinase. (795 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
ADIPOR1ADIPOR1 isoform 2. (375 aa)
EFNA1EFNA1 isoform 1; Belongs to the ephrin family. (205 aa)
CR201_G0015745TRIM62 isoform 3. (352 aa)
PDPNPDPN isoform 1. (236 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
GATA3GATA binding protein 3. (444 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
PTENPongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CR201_G0012836TCF7L2 isoform 2. (430 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
PHLDB1PHLDB1 isoform 1. (1423 aa)
BCL9LBCL9L isoform 4. (1542 aa)
PAWRPAWR isoform 3. (340 aa)
ALX1ALX homeobox 1. (326 aa)
TBX5T-box transcription factor 5. (518 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
FOXA1FOXA1 isoform 1. (448 aa)
FERMT2FERMT2 isoform 1. (623 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GREM1Gremlin. (184 aa)
ELL3ELL3 isoform 1. (397 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
VASNVASN isoform 1. (673 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
AXIN2AXIN2 isoform 1. (843 aa)
ZNF750Zinc finger protein 750. (723 aa)
COL1A1COL1A1 isoform 2. (1463 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC100441148SERPINB4 isoform 1; Belongs to the serpin family. (390 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (383 aa)
HPNSerine protease hepsin non-catalytic chain; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2 (By similarity). (417 aa)
SPRED3Sprouty related EVH1 domain containing 3. (410 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
DACT3DACT3 isoform 2. (516 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CR201_G0019832T0068022 isoform 1. (302 aa)
SNAI1SNAI1 isoform 1. (263 aa)
BMP7Bone morphogenetic protein 7. (365 aa)
TIAM1TIAM1 isoform 1. (1591 aa)
POFUT2Protein O-fucosyltransferase 2. (429 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
LOC100438930MDK isoform 6. (143 aa)
LOXL3LOXL3 isoform 4. (668 aa)
SPRED2Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. (418 aa)
CLASP1CLASP1 isoform 3. (1537 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
EPHA4EPHA4 isoform 2. (927 aa)
USF3USF3 isoform 1. (2239 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X2. (1280 aa)
EPHA3EPHA3 isoform 1. (983 aa)
IL17RDInterleukin 17 receptor D. (739 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
CLASP2CLASP2 isoform 2. (1505 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
DAB2DAB adaptor protein 2. (770 aa)
ISL1ISL1 isoform 1. (349 aa)
FOXC1FOXC1 isoform 1. (332 aa)
GCNT2GCNT2 isoform 18. (402 aa)
BMP5BMP5 isoform 1. (453 aa)
ENSPPYP00000018739annotation not available (186 aa)
HDAC2Histone deacetylase 2. (580 aa)
TBX20TBX20 isoform 1. (447 aa)
IL6IL6 isoform 2. (212 aa)
TWIST1Twist family bHLH transcription factor 1. (203 aa)
ZNF703ZNF703 isoform 1. (591 aa)
CR201_G0033322SFRP1 isoform 1. (260 aa)
SDCBPSDCBP isoform 3. (297 aa)
GLIPR2GLIPR2 isoform 1; Belongs to the CRISP family. (320 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
DAB2IPDAB2IP isoform 2. (1130 aa)
CRB2CRB2 isoform 2. (637 aa)
ENGENG isoform 3. (668 aa)
CR201_G0027392OLFM1 isoform 6. (357 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
EZH2EZH2 isoform 5. (704 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
LOXL2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (549 aa)
MCRIP1MCRIP1 isoform 12. (128 aa)
OVOL2Ovo like zinc finger 2. (289 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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