STRINGSTRING
TGFB2 TGFB2 PDPN PDPN BAMBI BAMBI CR201_G0012836 CR201_G0012836 BCL9L BCL9L ALX1 ALX1 FERMT2 FERMT2 BMP4 BMP4 TGFB3 TGFB3 SMAD3 SMAD3 EMP2 EMP2 TGFB1I1 TGFB1I1 AXIN2 AXIN2 COL1A1 COL1A1 SMAD2 SMAD2 SMAD4 SMAD4 LOC100441148 LOC100441148 LRG1 LRG1 TGFB1 TGFB1 JAG1 JAG1 SNAI1 SNAI1 BMP7 BMP7 TIAM1 TIAM1 IL1B IL1B LOC100438930 LOC100438930 LOXL3 LOXL3 ACVR1 ACVR1 CTNNB1 CTNNB1 TGFBR2 TGFBR2 WWTR1 WWTR1 LEF1 LEF1 DAB2 DAB2 ISL1 ISL1 FOXC1 FOXC1 GCNT2 GCNT2 ENSPPYP00000018739 ENSPPYP00000018739 HDAC2 HDAC2 TBX20 TBX20 IL6 IL6 TWIST1 TWIST1 ZNF703 ZNF703 SDCBP SDCBP GLIPR2 GLIPR2 TGFBR1 TGFBR1 CRB2 CRB2 ENG ENG CR201_G0027392 CR201_G0027392 NOTCH1 NOTCH1 EZH2 EZH2 BMP2 BMP2 LOXL2 LOXL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
PDPNPDPN isoform 1. (236 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
CR201_G0012836TCF7L2 isoform 2. (430 aa)
BCL9LBCL9L isoform 4. (1542 aa)
ALX1ALX homeobox 1. (326 aa)
FERMT2FERMT2 isoform 1. (623 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
AXIN2AXIN2 isoform 1. (843 aa)
COL1A1COL1A1 isoform 2. (1463 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC100441148SERPINB4 isoform 1; Belongs to the serpin family. (390 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (383 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SNAI1SNAI1 isoform 1. (263 aa)
BMP7Bone morphogenetic protein 7. (365 aa)
TIAM1TIAM1 isoform 1. (1591 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
LOC100438930MDK isoform 6. (143 aa)
LOXL3LOXL3 isoform 4. (668 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
DAB2DAB adaptor protein 2. (770 aa)
ISL1ISL1 isoform 1. (349 aa)
FOXC1FOXC1 isoform 1. (332 aa)
GCNT2GCNT2 isoform 18. (402 aa)
ENSPPYP00000018739annotation not available (186 aa)
HDAC2Histone deacetylase 2. (580 aa)
TBX20TBX20 isoform 1. (447 aa)
IL6IL6 isoform 2. (212 aa)
TWIST1Twist family bHLH transcription factor 1. (203 aa)
ZNF703ZNF703 isoform 1. (591 aa)
SDCBPSDCBP isoform 3. (297 aa)
GLIPR2GLIPR2 isoform 1; Belongs to the CRISP family. (320 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
CRB2CRB2 isoform 2. (637 aa)
ENGENG isoform 3. (668 aa)
CR201_G0027392OLFM1 isoform 6. (357 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
EZH2EZH2 isoform 5. (704 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
LOXL2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (549 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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