STRINGSTRING
SLC25A4 SLC25A4 TRIAP1 TRIAP1 BAK1 BAK1 ADCK1 ADCK1 AKT1 AKT1 TSC2 TSC2 NOL3 NOL3 MPV17L MPV17L TP53 TP53 VAT1 VAT1 ACAA2 ACAA2 AVP AVP BCL2L1 BCL2L1 TSPO TSPO SLC35F6 SLC35F6 BOK BOK PPARG PPARG OPA1 OPA1 TFRC TFRC SLC25A31 SLC25A31 USP30 USP30 PRELID1 PRELID1 CR201_G0016264 CR201_G0016264 TMEM14A TMEM14A GCLC GCLC CR201_G0036895 CR201_G0036895 FZD9 FZD9 HGF HGF CLU CLU FLCN FLCN PARL PARL ENSPPYP00000021457 ENSPPYP00000021457 CR201_G0001564 CR201_G0001564 HUWE1 HUWE1 PSMD10 PSMD10 SLC25A5 SLC25A5 GPX1 GPX1 TIGAR TIGAR C11orf65 C11orf65 BNIP3 BNIP3 PPIF PPIF GHITM GHITM MUL1 MUL1 PINK1 PINK1 OMA1 OMA1 LMNA LMNA ENSPPYP00000000548 ENSPPYP00000000548 RNF41 RNF41 IGF1 IGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
TRIAP1TRIAP1 isoform 1. (91 aa)
BAK1Bcl-2 homologous antagonist/killer. (147 aa)
ADCK1ADCK1 isoform 2. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
TSC2TSC2 isoform 1. (1738 aa)
NOL3NOL3 isoform 6. (207 aa)
MPV17LT0166455 isoform 1; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
VAT1VAT1 isoform 3. (399 aa)
ACAA23-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activit [...] (338 aa)
AVPAVP isoform 1; Belongs to the vasopressin/oxytocin family. (164 aa)
BCL2L1BCL2L1 isoform 2. (233 aa)
TSPOTranslocator protein. (169 aa)
SLC35F6Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). (371 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intri [...] (951 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (760 aa)
SLC25A31SLC25A31 isoform 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (253 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (513 aa)
PRELID1PRELI domain containing 1. (219 aa)
CR201_G0016264BAK1 isoform 3. (172 aa)
TMEM14ATransmembrane protein 14A. (99 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
CR201_G0036895PRKN isoform 8. (335 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (415 aa)
FLCNT0179577 isoform 1. (579 aa)
PARLPresenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). (408 aa)
ENSPPYP00000021457Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. (72 aa)
CR201_G0001564FXN isoform 5. (137 aa)
HUWE1HUWE1 isoform 1. (4373 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
SLC25A5ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). (530 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (271 aa)
C11orf65Chromosome 11 open reading frame 65. (313 aa)
BNIP3BNIP3 isoform 1. (256 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (209 aa)
GHITMGHITM isoform 1; Belongs to the BI1 family. (345 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
PINK1PTEN induced kinase 1. (581 aa)
OMA1OMA1 zinc metallopeptidase. (524 aa)
LMNALMNA isoform 2; Belongs to the intermediate filament family. (664 aa)
ENSPPYP00000000548annotation not available (162 aa)
RNF41E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa)
IGF1Insulin like growth factor 1. (159 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.