STRINGSTRING
LEFTY2 LEFTY2 ENSPPYP00000000171 ENSPPYP00000000171 TGFB2 TGFB2 BMP8B BMP8B CR201_G0015593 CR201_G0015593 GDF2 GDF2 GDF10 GDF10 BMPR1A BMPR1A NODAL NODAL GDF3 GDF3 ACVRL1 ACVRL1 INHBE INHBE BMP4 BMP4 TGFB3 TGFB3 TWSG1 TWSG1 SMAD4 SMAD4 GDF15 GDF15 TGFB1 TGFB1 GDF5 GDF5 BMP7 BMP7 BMP10 BMP10 GDF7 GDF7 INHBB INHBB ACVR2A ACVR2A ACVR1 ACVR1 MSTN MSTN BMPR2 BMPR2 INHA INHA PPARG PPARG TGFBR2 TGFBR2 BMP3 BMP3 DAB2 DAB2 GDF9 GDF9 BMP6 BMP6 HFE HFE BMP5 BMP5 TTK TTK INHBA INHBA RBPMS RBPMS SDCBP SDCBP GDF6 GDF6 TGFBR1 TGFBR1 ENG ENG BMP15 BMP15 BMP2 BMP2 GDF11 GDF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEFTY2Left-right determination factor. (366 aa)
ENSPPYP00000000171Left-right determination factor 1 isoform X1. (366 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
BMP8BBMP8B isoform 1. (336 aa)
CR201_G0015593BMP8A isoform 1. (357 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNodal growth differentiation factor. (347 aa)
GDF3Growth differentiation factor 3. (364 aa)
ACVRL1Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well (By similarity). (503 aa)
INHBEInhibin subunit beta E. (350 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TWSG1Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity); Belongs to the twisted gastrulation protei [...] (223 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF15Growth differentiation factor 15. (308 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
GDF5Growth differentiation factor 5. (501 aa)
BMP7Bone morphogenetic protein 7. (365 aa)
BMP10BMP10 isoform 1. (424 aa)
GDF7GDF7 isoform 1. (447 aa)
INHBBINHBB isoform 1. (273 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MSTNMSTN isoform 1. (375 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
DAB2DAB adaptor protein 2. (770 aa)
GDF9Growth differentiation factor 9. (455 aa)
BMP6BMP6 isoform 1. (510 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
BMP5BMP5 isoform 1. (453 aa)
TTKTTK isoform 4. (855 aa)
INHBAInhibin subunit beta A. (426 aa)
RBPMSRNA binding protein, mRNA processing factor. (219 aa)
SDCBPSDCBP isoform 3. (297 aa)
GDF6Growth differentiation factor 6. (455 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
ENGENG isoform 3. (668 aa)
BMP15BMP15 isoform 1. (393 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GDF11GDF11 isoform 2. (263 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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