52 items (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPYP00000000181	annotation not available (121 aa)
	KLHL12	KLHL12 isoform 2. (567 aa)
	SEC16B	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (950 aa)
	SEC22B	Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
	PEF1	Penta-EF-hand domain containing 1. (284 aa)
	SEC24C	SEC24C isoform 1. (1095 aa)
	SAR1A	GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity). (198 aa)
	SEC31B	LOW QUALITY PROTEIN: protein transport protein Sec31B. (1149 aa)
	VTI1A	Vesicle transport through interaction with t-SNAREs 1A. (217 aa)
	SEC23IP	SEC23IP isoform 1. (1018 aa)
	CNIH2	Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
	STX5	STX5 isoform 1; Belongs to the syntaxin family. (355 aa)
	SEC23A	Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (713 aa)
	VTI1B	Vesicle transport through interaction with t-SNAREs 1B. (232 aa)
	ENSPPYP00000008251	annotation not available (212 aa)
	SREBF1	SREBF1 isoform 2. (1153 aa)
	GOSR2	T0082108 isoform 1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa)
	SEC23B	Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. (767 aa)
	SREBF2	SREBF2 isoform 1. (1058 aa)
	TGFA	TGFA isoform 5. (159 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
	SCAP	SCAP isoform 2. (1278 aa)
	AREG	AREG isoform 1. (252 aa)
	USO1	USO1 isoform 2. (969 aa)
	SEC31A	Protein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1121 aa)
	SEC24D	SEC24D isoform 7. (1002 aa)
	PDCD6	Programmed cell death protein 6 isoform X1. (191 aa)
	SAR1B	Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	SEC24A	SEC24 homolog A, COPII coat complex component. (1093 aa)
	CD74	CD74 isoform 2. (232 aa)
	GRIA1	GRIA1 isoform 7. (888 aa)
	HLA-A	Popy Class I histocompatibility antigen, A-1 alpha chain. (365 aa)
	HLA-DRB5	Ig-like domain-containing protein. (266 aa)
	CR201_G0016196	HLA-DQB1 isoform 5. (304 aa)
	CR201_G0055889	Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
	MHC-Poab-B	MHC class I antigen; Belongs to the MHC class I family. (323 aa)
	CR201_G0016191	HLA-DRB5 isoform 1. (290 aa)
	ENSPPYP00000019293	HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa)
	HLA-DQB2	Major histocompatibility complex, class II, DQ beta 2. (264 aa)
	CR201_G0016218	HLA-DPA1 isoform 1; Belongs to the MHC class II family. (260 aa)
	CR201_G0016219	HLA-DPB1 isoform 1. (283 aa)
	CR201_G0042422	HLA-G isoform 2; Belongs to the MHC class I family. (365 aa)
	LOC100460187	MHC class II protein; Belongs to the MHC class II family. (254 aa)
	ENSPPYP00000019322	annotation not available (157 aa)
	CR201_G0016218-2	HLA-DPA1 isoform 3. (239 aa)
	CR201_G0055693	HLA-B isoform 1; Belongs to the MHC class I family. (362 aa)
	STX17	STX17 isoform 1; Belongs to the syntaxin family. (302 aa)
	SEC16A	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2328 aa)
	VMA21	Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. (101 aa)
	SEC24B	SEC24B isoform 3. (1137 aa)
	HLA-DPB1	Major histocompatibility complex, class II, DP beta 1. (258 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	CNIH2	ENSPPYP00000016568	ENSPPYP00000003506	AREG isoform 1.	Cornichon family AMPA receptor auxiliary protein 2.	0.404
AREG	ENSPPYP00000000181	ENSPPYP00000016568	ENSPPYP00000000181	AREG isoform 1.	annotation not available	0.404
AREG	STX17	ENSPPYP00000016568	ENSPPYP00000021787	AREG isoform 1.	STX17 isoform 1; Belongs to the syntaxin family.	0.446
AREG	TGFA	ENSPPYP00000016568	ENSPPYP00000013742	AREG isoform 1.	TGFA isoform 5.	0.796
CD74	CR201_G0016191	ENSPPYP00000017848	ENSPPYP00000019292	CD74 isoform 2.	HLA-DRB5 isoform 1.	0.636
CD74	CR201_G0016196	ENSPPYP00000017848	ENSPPYP00000018443	CD74 isoform 2.	HLA-DQB1 isoform 5.	0.997
CD74	CR201_G0016218	ENSPPYP00000017848	ENSPPYP00000019310	CD74 isoform 2.	HLA-DPA1 isoform 1; Belongs to the MHC class II family.	0.847
CD74	CR201_G0016218-2	ENSPPYP00000017848	ENSPPYP00000019340	CD74 isoform 2.	HLA-DPA1 isoform 3.	0.984
CD74	CR201_G0016219	ENSPPYP00000017848	ENSPPYP00000019311	CD74 isoform 2.	HLA-DPB1 isoform 1.	0.960
CD74	ENSPPYP00000019293	ENSPPYP00000017848	ENSPPYP00000019293	CD74 isoform 2.	HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1.	0.970
CD74	ENSPPYP00000019322	ENSPPYP00000017848	ENSPPYP00000019322	CD74 isoform 2.	annotation not available	0.618
CD74	HLA-DPB1	ENSPPYP00000017848	ENSPPYP00000024121	CD74 isoform 2.	Major histocompatibility complex, class II, DP beta 1.	0.618
CD74	HLA-DQB2	ENSPPYP00000017848	ENSPPYP00000019299	CD74 isoform 2.	Major histocompatibility complex, class II, DQ beta 2.	0.980
CD74	HLA-DRB5	ENSPPYP00000017848	ENSPPYP00000018440	CD74 isoform 2.	Ig-like domain-containing protein.	0.973
CD74	LOC100460187	ENSPPYP00000017848	ENSPPYP00000019319	CD74 isoform 2.	MHC class II protein; Belongs to the MHC class II family.	0.999
CD74	SAR1A	ENSPPYP00000017848	ENSPPYP00000002755	CD74 isoform 2.	GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity).	0.406
CD74	SAR1B	ENSPPYP00000017848	ENSPPYP00000017655	CD74 isoform 2.	Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family.	0.406
CNIH2	AREG	ENSPPYP00000003506	ENSPPYP00000016568	Cornichon family AMPA receptor auxiliary protein 2.	AREG isoform 1.	0.404
CNIH2	GRIA1	ENSPPYP00000003506	ENSPPYP00000017871	Cornichon family AMPA receptor auxiliary protein 2.	GRIA1 isoform 7.	0.959
CNIH2	SAR1A	ENSPPYP00000003506	ENSPPYP00000002755	Cornichon family AMPA receptor auxiliary protein 2.	GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity).	0.454