STRINGSTRING
PTN PTN BMP2 BMP2 ID4 ID4 SIRT2 SIRT2 CLCF1 CLCF1 EZH2 EZH2 MECP2 MECP2 NOTCH1 NOTCH1 CDKN2B CDKN2B PLAG1 PLAG1 LYN LYN SHH SHH RHEB RHEB PTPRZ1 PTPRZ1 IL6 IL6 HDAC2 HDAC2 NR2E1 NR2E1 UFL1 UFL1 ENSPPYP00000018739 ENSPPYP00000018739 TTBK1 TTBK1 TREM2 TREM2 DAAM2 DAAM2 TNF TNF IL6ST IL6ST ATOH1 ATOH1 VEGFC VEGFC NKX6-1 NKX6-1 GSX2 GSX2 HES1 HES1 PRKCI PRKCI CTNNB1 CTNNB1 PPARG PPARG SERPINE2 SERPINE2 DLX2 DLX2 DLX1 DLX1 LRP2 LRP2 BIN1 BIN1 LOC100438930 LOC100438930 IL1B IL1B TSPO TSPO SOX10 SOX10 LIF LIF NF2 NF2 OLIG2 OLIG2 SYNJ1 SYNJ1 E2F1 E2F1 NKX2-2 NKX2-2 TGFB1 TGFB1 MAG MAG LDLR LDLR MBD1 MBD1 NR1D1 NR1D1 GFAP GFAP NOG NOG TMEM98 TMEM98 NF1 NF1 RNF112 RNF112 CR201_G0035363 CR201_G0035363 TP53 TP53 ASPA ASPA SLC7A5 SLC7A5 IL34 IL34 SOX8 SOX8 SPINT1 SPINT1 DICER1 DICER1 RB1 RB1 RNF10 RNF10 PPP1CC PPP1CC KRAS KRAS NTF3 NTF3 CR201_G0026159 CR201_G0026159 TENM4 TENM4 F2 F2 PRPF19 PRPF19 ACY3 ACY3 ASCL2 ASCL2 NKX6-2 NKX6-2 PITX3 PITX3 ZNF365 ZNF365 EGR2 EGR2 SKI SKI TP73 TP73 TNFRSF1B TNFRSF1B LIN28A LIN28A HDAC1 HDAC1 DAB1 DAB1 CERS2 CERS2 GPR37L1 GPR37L1 DUSP10 DUSP10 GJC2 GJC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTNPTN isoform 1. (168 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] (389 aa)
CLCF1Cardiotrophin-like cytokine factor 1 isoform X3. (182 aa)
EZH2EZH2 isoform 5. (704 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (444 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (137 aa)
PLAG1PLAG1 isoform 1. (499 aa)
LYNTyrosine-protein kinase. (512 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
RHEBRHEB isoform 1. (167 aa)
PTPRZ1PTPRZ1 isoform 1. (2317 aa)
IL6IL6 isoform 2. (212 aa)
HDAC2Histone deacetylase 2. (580 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
UFL1UFL1 isoform 2. (773 aa)
ENSPPYP00000018739annotation not available (186 aa)
TTBK1TTBK1 isoform 1. (1323 aa)
TREM2TREM2 isoform 1. (202 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
IL6STIL6ST isoform 1. (935 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
VEGFCVEGFC isoform 1; Belongs to the PDGF/VEGF growth factor family. (418 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
GSX2GSX2 isoform 2. (305 aa)
HES1HES1 isoform 1. (198 aa)
PRKCIProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] (690 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
SERPINE2SERPINE2 isoform 5; Belongs to the serpin family. (409 aa)
DLX2Distal-less homeobox 2. (328 aa)
DLX1Distal-less homeobox 1. (255 aa)
LRP2LRP2 isoform 1. (4512 aa)
BIN1BIN1 isoform 9. (517 aa)
LOC100438930MDK isoform 6. (143 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
TSPOTranslocator protein. (169 aa)
SOX10SOX10 isoform 2. (436 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
NF2Neurofibromin 2. (590 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
SYNJ1SYNJ1 isoform 6. (1396 aa)
E2F1E2F1 isoform 1. (361 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
MAGMAG isoform 1. (627 aa)
LDLRLDLR isoform 3. (815 aa)
MBD1MBD1 isoform 3. (667 aa)
NR1D1NR1D1 isoform 1. (612 aa)
GFAPGlial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. (431 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TMEM98Transmembrane protein 98. (226 aa)
NF1NF1 isoform 6. (2838 aa)
RNF112RNF112 isoform 1. (632 aa)
CR201_G0035363NTN1 isoform 1. (337 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ASPAAspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids (By similarity). (313 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
IL34IL34 isoform 1. (242 aa)
SOX8SRY-box transcription factor 8. (446 aa)
SPINT1SPINT1 isoform 1. (531 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
RB1RB1 isoform 1. (928 aa)
RNF10RNF10 isoform 1. (725 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
CR201_G0026159ABCC8 isoform 10. (685 aa)
TENM4TENM4 isoform 2. (2794 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
PRPF19PRPF19 isoform 1. (523 aa)
ACY3ACY3 isoform 1. (315 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
NKX6-2NKX6-2 isoform 2. (277 aa)
PITX3Homeobox protein. (302 aa)
ZNF365Protein ZNF365; Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (By similarity). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand [...] (407 aa)
EGR2Early growth response 2. (476 aa)
SKISKI isoform 1. (406 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (522 aa)
TNFRSF1BTNFRSF1B isoform 2. (455 aa)
LIN28ALIN28A isoform 1. (209 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa)
DAB1DAB adaptor protein 1. (555 aa)
CERS2CERS2 isoform 5. (380 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (441 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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