STRINGSTRING
PREX2 PREX2 PIK3CG PIK3CG KBTBD2 KBTBD2 NYAP1 NYAP1 PPARD PPARD EDN1 EDN1 PIK3R1 PIK3R1 PIK3CB PIK3CB NYAP2 NYAP2 ENSPPYP00000014637 ENSPPYP00000014637 XBP1 XBP1 CR201_G0037390 CR201_G0037390 ERBB2 ERBB2 NF1 NF1 PIK3R5 PIK3R5 C1QBP C1QBP IGF1R IGF1R LTK LTK AKT1 AKT1 PIK3C2B PIK3C2B MYO16 MYO16 HTR2A HTR2A CR201_G0055568 CR201_G0055568 IGF1 IGF1 ERBB3 ERBB3 PRR5L PRR5L PTEN PTEN GATA3 GATA3 PLEKHA1 PLEKHA1 ZFP36L1 ZFP36L1 SERPINA12 SERPINA12 PIK3CD PIK3CD CD160 CD160 PEAR1 PEAR1 SIRT2 SIRT2 PIK3CA PIK3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PREX2PREX2 isoform 1. (1591 aa)
PIK3CGPIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. (1102 aa)
KBTBD2Kelch repeat and BTB domain-containing protein 2. (623 aa)
NYAP1NYAP1 isoform 1. (841 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
EDN1EDN1 isoform 1. (212 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
NYAP2NYAP2 isoform 1. (645 aa)
ENSPPYP00000014637annotation not available (137 aa)
XBP1X-box binding protein 1. (262 aa)
CR201_G0037390PIK3R2 isoform 1. (641 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
NF1NF1 isoform 6. (2838 aa)
PIK3R5PIK3R5 isoform 10. (883 aa)
C1QBPComplement C1q binding protein. (281 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
MYO16MYO16 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1861 aa)
HTR2AHTR2A isoform 2. (353 aa)
CR201_G0055568TPTE2 isoform 2. (126 aa)
IGF1Insulin like growth factor 1. (159 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. (1342 aa)
PRR5LProline rich 5 like. (368 aa)
PTENPongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GATA3GATA binding protein 3. (444 aa)
PLEKHA1PLEKHA1 isoform 4. (383 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
SERPINA12SERPINA12 isoform 1; Belongs to the serpin family. (412 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
CD160CD160 isoform 1. (181 aa)
PEAR1PEAR1 isoform 2. (1037 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] (389 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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