STRINGSTRING
GLRX GLRX ENSPPYP00000016598 ENSPPYP00000016598 GRXCR1 GRXCR1 STAB1 STAB1 PDIA5 PDIA5 TXNRD3 TXNRD3 DNAJC10 DNAJC10 CR201_G0024663 CR201_G0024663 TXNRD2 TXNRD2 NXNL1 NXNL1 TMEM221 TMEM221 CR201_G0002531 CR201_G0002531 P4HB P4HB TXNDC17 TXNDC17 NXN NXN GFER GFER PDIA2 PDIA2 PDIA3 PDIA3 GLRX5 GLRX5 ERO1A ERO1A ENOX1 ENOX1 CR201_G0001249 CR201_G0001249 STAB2 STAB2 CCS CCS GLRX3 GLRX3 TXNDC12 TXNDC12 QSOX1 QSOX1 GLRX2 GLRX2 ERO1B ERO1B SELENOT SELENOT TXNL1 TXNL1 CHCHD4 CHCHD4 ENOX2 ENOX2 QSOX2 QSOX2 TXNDC8 TXNDC8 TXN TXN NXNL2 NXNL2 GSR GSR TXNDC5 TXNDC5 ENSPPYP00000018104 ENSPPYP00000018104 GRXCR2 GRXCR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLRXGLRX isoform 1. (106 aa)
ENSPPYP00000016598annotation not available (104 aa)
GRXCR1GRXCR1 isoform 1. (231 aa)
STAB1STAB1 isoform 1. (2509 aa)
PDIA5Protein disulfide isomerase family A member 5. (519 aa)
TXNRD3TXNRD3 isoform 1. (569 aa)
DNAJC10DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...] (793 aa)
CR201_G0024663TXN2 isoform 1. (129 aa)
TXNRD2Thioredoxin reductase 2. (522 aa)
NXNL1NXNL1 isoform 1. (109 aa)
TMEM221Transmembrane protein 221 isoform X1. (129 aa)
CR201_G0002531TXNDC2 isoform 4. (478 aa)
P4HBProtein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (508 aa)
TXNDC17Thioredoxin domain-containing protein 17; Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity); Belongs to the thioredoxin family. (123 aa)
NXNNXN isoform 1. (390 aa)
GFERSulfhydryl oxidase. (81 aa)
PDIA2Protein disulfide-isomerase A2; Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity); Belongs to the protein disulfide isomerase family. (521 aa)
PDIA3Protein disulfide-isomerase A3. (466 aa)
GLRX5GLRX5 isoform 2. (157 aa)
ERO1AERO1A isoform 1. (467 aa)
ENOX1ENOX1 isoform 1. (687 aa)
CR201_G0001249TXNRD1 isoform 17. (277 aa)
STAB2STAB2 isoform 1. (2293 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
GLRX3GLRX3 isoform 1. (335 aa)
TXNDC12Thioredoxin domain containing 12. (172 aa)
QSOX1Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. (607 aa)
GLRX2Glutaredoxin-2, mitochondrial; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylat [...] (161 aa)
ERO1BERO1B isoform 1. (394 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
TXNL1Thioredoxin like 1. (292 aa)
CHCHD4Coiled-coil-helix-coiled-coil-helix domain containing 4. (142 aa)
ENOX2Ecto-NOX disulfide-thiol exchanger 2. (610 aa)
QSOX2Sulfhydryl oxidase. (576 aa)
TXNDC8TXNDC8 isoform 3. (115 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (220 aa)
NXNL2Nucleoredoxin like 2. (156 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (472 aa)
TXNDC5Thioredoxin domain-containing protein 5. (431 aa)
ENSPPYP00000018104annotation not available (312 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (248 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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