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| | RAB29 | Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] (203 aa) |
| | LYST | LYST isoform 5. (3756 aa) |
| | ENSPPYP00000000352 | annotation not available (88 aa) |
| | DENND1B | DENND1B isoform 3. (425 aa) |
| | STX6 | Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa) |
| | VAMP4 | VAMP4 isoform 1. (134 aa) |
| | RAB13 | RAB13 isoform 2. (203 aa) |
| | SNX27 | SNX27 isoform 2. (528 aa) |
| | SORT1 | Sortilin. (789 aa) |
| | SNX7 | SNX7 isoform 1. (473 aa) |
| | EVI5 | Ecotropic viral integration site 5. (810 aa) |
| | CR201_G0020056 | BTBD8 isoform 2. (438 aa) |
| | ZFYVE9 | Zinc finger FYVE domain-containing protein. (1390 aa) |
| | EPS15 | Epidermal growth factor receptor pathway substrate 15. (896 aa) |
| | TINAGL1 | Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family. (467 aa) |
| | TMEM50A | TMEM50A isoform 1. (157 aa) |
| | VAMP3 | Vesicle associated membrane protein 3. (100 aa) |
| | STAM | Signal transducing adaptor molecule. (540 aa) |
| | Washc2 | WASH complex subunit 2; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation- promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] (1331 aa) |
| | LOC100433557 | Annexin. (327 aa) |
| | VPS26A | VPS26, retromer complex component A. (327 aa) |
| | BLOC1S2 | BLOC1S2 isoform 1. (99 aa) |
| | GBF1 | GBF1 isoform 1. (1855 aa) |
| | VTI1A | Vesicle transport through interaction with t-SNAREs 1A. (217 aa) |
| | DENND10 | FAM45A isoform 2. (405 aa) |
| | TBC1D10C | TBC1D10C isoform 5. (435 aa) |
| | SNX32 | Sorting nexin; Involved in several stages of intracellular trafficking. (400 aa) |
| | VPS51 | VPS51 isoform 3. (303 aa) |
| | EHD1 | EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary v [...] (534 aa) |
| | STX5 | STX5 isoform 1; Belongs to the syntaxin family. (355 aa) |
| | ARHGAP1 | ARHGAP1 isoform 3. (504 aa) |
| | TSG101 | TSG101 isoform 4. (352 aa) |
| | RASSF10 | RASSF10 isoform 1. (419 aa) |
| | DENND5A | DENND5A isoform 1. (1191 aa) |
| | LAMTOR1 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] (161 aa) |
| | PICALM | PICALM isoform 11. (686 aa) |
| | VPS26B | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for car [...] (336 aa) |
| | CR201_G0036182 | CRACR2A isoform 1. (319 aa) |
| | GOLT1B | Golgi transport 1B. (138 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa) |
| | GRIP1 | GRIP1 isoform 2. (1016 aa) |
| | ARL1 | ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family. (181 aa) |
| | WASHC3 | WASHC3 isoform 2. (194 aa) |
| | WASHC4 | WASHC4 isoform 1. (1120 aa) |
| | CORO1C | Coronin; Belongs to the WD repeat coronin family. (434 aa) |
| | VPS29 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] (182 aa) |
| | PHETA1 | PH domain containing endocytic trafficking adaptor 1. (247 aa) |
| | RAB35 | RAB35, member RAS oncogene family. (201 aa) |
| | VPS37B | VPS37B isoform 1. (285 aa) |
| | DCLK1 | DCLK1 isoform 4. (701 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | HEATR5A | HEATR5A isoform 1. (1951 aa) |
| | SNX6 | Sorting nexin-6, N-terminally processed; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome- to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile call [...] (389 aa) |
| | ARF6 | ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa) |
| | AP5M1 | Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (490 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) |
| | EHD4 | EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa) |
| | VPS39 | VPS39 isoform 1. (875 aa) |
| | TMEM87A | TMEM87A isoform 1. (562 aa) |
| | SNX1 | Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa) |
| | SNX33 | Sorting nexin. (572 aa) |
| | ENSPPYP00000007763 | annotation not available (222 aa) |
| | LOC100437697 | RAB11FIP3 isoform 1. (536 aa) |
| | BAIAP3 | BAIAP3 isoform 3. (1072 aa) |
| | SRL | SRL isoform 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (429 aa) |
| | CLEC16A | CLEC16A isoform 1. (960 aa) |
| | VPS35L | VPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numero [...] (992 aa) |
| | TBC1D10B | TBC1 domain family member 10B. (812 aa) |
| | VPS4A | VPS4A isoform 1; Belongs to the AAA ATPase family. (437 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa) |
| | VPS53 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] (770 aa) |
| | TRARG1 | Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa) |
| | RILP | RILP isoform 2. (400 aa) |
| | SGSM2 | SGSM2 isoform 3. (1040 aa) |
| | ANKFY1 | Ankyrin repeat and FYVE domain containing 1. (1170 aa) |
| | ARHGAP44 | ARHGAP44 isoform 2. (736 aa) |
| | RAB11FIP4 | RAB11FIP4 isoform 1. (557 aa) |
| | ENSPPYP00000009265 | annotation not available (102 aa) |
| | SPAG9 | Sperm associated antigen 9. (1307 aa) |
| | VPS25 | VPS25 isoform 1. (174 aa) |
| | GGA3 | GGA3 isoform 1. (716 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1293 aa) |
| | CR201_G0021153 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (616 aa) |
| | CLTC | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa) |
| | SNF8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (279 aa) |
| | EPG5 | EPG5 isoform 1. (2578 aa) |
| | MYO5B | T0098307 isoform 1. (1849 aa) |
| | SLC66A2 | Solute carrier family 66 member 2. (271 aa) |
| | RNF126 | RNF126 isoform 1. (240 aa) |
| | AP3D1 | AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1099 aa) |
| | PLEKHJ1 | PLEKHJ1 isoform 1. (149 aa) |
| | UBXN6 | UBXN6 isoform 3. (436 aa) |
| | DENND1C | DENND1C isoform 1. (616 aa) |
| | RAB11B | RAB11B, member RAS oncogene family. (218 aa) |
| | STX10 | STX10 isoform 6; Belongs to the syntaxin family. (249 aa) |
| | MVB12A | Multivesicular body subunit 12A. (273 aa) |
| | ANKRD27 | Ankyrin repeat domain-containing protein 27; May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (By similarity). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the fun [...] (893 aa) |
| | ENSPPYP00000011173 | annotation not available (222 aa) |
| | EHD2 | EHD2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (605 aa) |
| | TBC1D17 | TBC1 domain family member 17. (648 aa) |
| | CHMP2A | CHMP2A isoform 1. (222 aa) |
| | SNX5 | Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa) |
| | CHMP4B | CHMP4B isoform 1. (210 aa) |
| | STX16 | STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa) |
| | ARFRP1 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. (201 aa) |
| | TMEM50B | Transmembrane protein 50B; Belongs to the UPF0220 family. (157 aa) |
| | ITSN1 | ITSN1 isoform 4. (1610 aa) |
| | VPS26C | Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of nu [...] (297 aa) |
| | TRAPPC10 | TRAPPC10 isoform 2. (1259 aa) |
| | CLTCL1 | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa) |
| | TBC1D10A | TBC1 domain family member 10A. (503 aa) |
| | TOM1 | TOM1 isoform 6; Belongs to the TOM1 family. (459 aa) |
| | GGA1 | GGA1 isoform 1. (634 aa) |
| | PHETA2 | PH domain containing endocytic trafficking adaptor 2. (259 aa) |
| | GCC2 | GCC2 isoform 3. (1686 aa) |
| | CR201_G0003005 | T0009947 isoform 1. (1278 aa) |
| | ALMS1 | ALMS1 isoform 2. (4160 aa) |
| | VPS54 | VPS54 subunit of GARP complex. (977 aa) |
| | PREPL | Prolyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). (705 aa) |
| | HEATR5B | HEATR5B isoform 1. (1991 aa) |
| | DPY30 | Dpy-30 histone methyltransferase complex regulatory subunit. (99 aa) |
| | EHD3 | EHD3 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa) |
| | SNX17 | Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (470 aa) |
| | RAB10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa) |
| | ITSN2 | ITSN2 isoform 3. (1658 aa) |
| | LAPTM4A | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. (233 aa) |
| | ENSPPYP00000014104 | annotation not available (161 aa) |
| | EIPR1 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. (409 aa) |
| | CCDC93 | Coiled-coil domain containing 93. (631 aa) |
| | WASHC1 | WAS protein family homolog 1. (467 aa) |
| | STAM2 | STAM2 isoform 1. (563 aa) |
| | ALS2 | ALS2 isoform 1. (1638 aa) |
| | PIKFYVE | PIKFYVE isoform 1. (2088 aa) |
| | ARL4C | ADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family. (201 aa) |
| | RAB17 | RAB17 isoform 2. (212 aa) |
| | GRIP2 | GRIP2 isoform 4. (1002 aa) |
| | RBSN | Rabenosyn, RAB effector. (784 aa) |
| | TMCC1 | Transmembrane and coiled-coil domain family 1. (653 aa) |
| | RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa) |
| | SNX4 | Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family. (450 aa) |
| | TBC1D23 | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1 (By similarity). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outg [...] (699 aa) |
| | ARL8B | ADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). (185 aa) |
| | PTPN23 | PTPN23 isoform 3. (1636 aa) |
| | ALS2CL | ALS2CL isoform 2. (909 aa) |
| | CMTM6 | CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...] (183 aa) |
| | TBC1D5 | TBC1D5 isoform 1. (784 aa) |
| | RAB6B | RAB6B, member RAS oncogene family. (208 aa) |
| | ACAP2 | ACAP2 isoform 1. (773 aa) |
| | NSG1 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa) |
| | KIAA1109 | KIAA1109 isoform 1. (4939 aa) |
| | ANKRD50 | ANKRD50 isoform 2. (1429 aa) |
| | SNX18 | Sorting nexin. (624 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa) |
| | ZFYVE16 | Zinc finger FYVE domain-containing protein. (1539 aa) |
| | RHOBTB3 | RHOBTB3 isoform 7. (548 aa) |
| | NSG2 | Neuronal vesicle trafficking associated 2. (171 aa) |
| | LRRC1 | Leucine rich repeat containing 1. (524 aa) |
| | REPS1 | RALBP1 associated Eps domain containing 1. (796 aa) |
| | VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). (307 aa) |
| | VPS52 | VPS52 isoform 4. (723 aa) |
| | MICALL2 | MICALL2 isoform 9. (905 aa) |
| | SNX8 | Sorting nexin 8. (465 aa) |
| | LMTK2 | LMTK2 isoform 1. (1474 aa) |
| | YKT6 | YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa) |
| | VPS50 | VPS50 isoform 2. (964 aa) |
| | DENND2A | DENND2A isoform 4. (1009 aa) |
| | VPS37A | VPS37A subunit of ESCRT-I. (397 aa) |
| | LEPROTL1 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). Belongs to the OB-RGRP/VPS55 family. (131 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (233 aa) |
| | LAPTM4B | LAPTM4B isoform 1. (193 aa) |
| | SCRIB | SCRIB isoform 2. (1472 aa) |
| | VPS28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (205 aa) |
| | RGP1 | RGP1 homolog, RAB6A GEF complex partner 1. (391 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase isoform X1. (806 aa) |
| | UBAP1 | UBAP1 isoform 1. (314 aa) |
| | RIC1 | RIC1 isoform 3. (1344 aa) |
| | ABCA1 | ABCA1 isoform 1. (2234 aa) |
| | SNX30 | Sorting nexin family member 30. (437 aa) |
| | RAB14 | Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell [...] (179 aa) |
| | DENND1A | DENND1A isoform 1. (1008 aa) |
| | MVB12B | MVB12B isoform 1. (278 aa) |
| | ENTR1 | SDCCAG3 isoform 2. (362 aa) |
| | CALY | CALY isoform 1. (217 aa) |
| | REPS2 | REPS2 isoform 2. (655 aa) |
| | WAS | WAS isoform 1. (445 aa) |
| | CR201_G0052920 | GRIPAP1 isoform 14. (643 aa) |
| | CCDC22 | CCDC22 isoform 1. (608 aa) |
| | SNX12 | Sorting nexin 12. (162 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (475 aa) |
| | SNX9 | Sorting nexin. (618 aa) |
| | EPS15L1 | Epidermal growth factor receptor pathway substrate 15 like 1. (926 aa) |
| | ERC1 | ELKS/RAB6-interacting/CAST family member 1. (1120 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | TMEM87B | Transmembrane protein 87B. (554 aa) |
| | ENSPPYP00000024575 | BTB/POZ domain-containing protein 8. (1022 aa) |
| | AP5B1 | AP5B1 isoform 1. (878 aa) |
| | SNX2 | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (523 aa) |
