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| | FYCO1 | FYVE and coiled-coil domain containing 1. (1478 aa) |
| | CR201_G0007982 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | TMEM39A | Transmembrane protein 39A. (488 aa) |
| | SNX4 | Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family. (450 aa) |
| | RUFY4 | RUFY4 isoform 7. (607 aa) |
| | RAB3GAP1 | RAB3GAP1 isoform 3. (975 aa) |
| | FEZ2 | FEZ2 isoform 2. (379 aa) |
| | ATP6V1C2 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (389 aa) |
| | ATP6V1E2 | ATPase H+ transporting V1 subunit E2. (226 aa) |
| | HMOX1 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (288 aa) |
| | ATP6V1E1 | ATP6V1E1 isoform 1. (203 aa) |
| | CHMP4B | CHMP4B isoform 1. (210 aa) |
| | SNX5 | Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa) |
| | EXOC8 | EXOC8 isoform 1. (728 aa) |
| | AMBRA1 | AMBRA1 isoform 3. (1241 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | SUPT5H | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] (1072 aa) |
| | SESN3 | SESN3 isoform 1. (491 aa) |
| | FEZ1 | Fasciculation and elongation protein zeta 1. (392 aa) |
| | CR201_G0050832 | NRBP2 isoform 6. (251 aa) |
| | ENSPPYP00000021457 | Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. (72 aa) |
| | C9orf72 | C9orf72-SMCR8 complex subunit. (481 aa) |
| | SPTLC1 | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] (473 aa) |
| | SNX30 | Sorting nexin family member 30. (437 aa) |
| | LRSAM1 | LRSAM1 isoform 1. (689 aa) |
| | TSC1 | TSC1 isoform 8. (1157 aa) |
| | GPSM1 | GPSM1 isoform 3. (649 aa) |
| | TBC1D25 | TBC1D25 isoform 1. (616 aa) |
| | HDAC6 | HDAC6 isoform 2. (1208 aa) |
| | UBQLN2 | UBQLN2 isoform 1. (624 aa) |
| | MTMR8 | MTMR8 isoform 1. (704 aa) |
| | SLC25A5 | ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). (530 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (435 aa) |
| | PAFAH1B2 | Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit (By similarity); Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. (241 aa) |
| | LRRK2 | LRRK2 isoform 3. (1560 aa) |
| | EPM2A | EPM2A glucan phosphatase, laforin. (331 aa) |
| | ENSPPYP00000024559 | annotation not available (71 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | SNX7 | SNX7 isoform 1. (473 aa) |
| | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa) |
| | ATP6V0B | ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family. (156 aa) |
| | TMEM39B | TMEM39B isoform 5. (424 aa) |
| | SESN2 | Sestrin-2; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcripti [...] (480 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1175 aa) |
| | VPS13D | VPS13D isoform 1. (4302 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (347 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (647 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | VPS26A | VPS26, retromer complex component A. (327 aa) |
| | SIRT1 | SIRT1 isoform 1. (746 aa) |
| | BAG3 | BAG3 isoform 1. (574 aa) |
| | BNIP3 | BNIP3 isoform 1. (256 aa) |
| | SNX32 | Sorting nexin; Involved in several stages of intracellular trafficking. (400 aa) |
| | ATG2A | ATG2A isoform 1. (1932 aa) |
| | BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | POLDIP2 | POLDIP2 isoform 1. (368 aa) |
| | RAB3GAP2 | RAB3GAP2 isoform 1. (1393 aa) |
| | QSOX1 | Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. (607 aa) |
| | UBQLN4 | UBQLN4 isoform 1. (600 aa) |
| | SEC22B | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa) |
| | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (862 aa) |
| | ERN1 | ERN1 isoform 1. (963 aa) |
| | CR201_G0024013 | WIPI1 isoform 2. (251 aa) |
| | EXOC7 | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (732 aa) |
| | TSC2 | TSC2 isoform 1. (1738 aa) |
| | WDR24 | WDR24 isoform 1. (868 aa) |
| | VPS13C | VPS13C isoform 1. (3448 aa) |
| | NEDD4 | E3 ubiquitin-protein ligase. (937 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | MOAP1 | MOAP1 isoform 1. (351 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (564 aa) |
| | CR201_G0009767 | HIF1A isoform 5. (735 aa) |
| | ATG14 | Autophagy related 14. (492 aa) |
| | SCFD1 | SCFD1 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (644 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | RNF31 | T0114761 isoform 1. (1053 aa) |
| | ULK1 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa) |
| | USP30 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (513 aa) |
| | DCN | Decorin; May affect the rate of fibrils formation. (359 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. (421 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa) |
| | LACRT | LACRT isoform 1. (137 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (271 aa) |
| | USP36 | Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1124 aa) |
| | CALCOCO2 | Calcium-binding and coiled-coil domain-containing protein 2; Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen- containing autophagosome maturation (By similarity). Bacteria targeting [...] (447 aa) |
| | NPC1 | NPC1 isoform 1. (1243 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | CAPNS1 | CAPNS1 isoform 1. (268 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa) |
| | KIAA1324 | KIAA1324 isoform 4. (1013 aa) |
| | SCOC | Short coiled-coil protein. (159 aa) |
| | CLEC16A | CLEC16A isoform 1. (960 aa) |
| | ATP6V0C | V-type H+-transporting ATPase 16kDa proteolipid subunit. (128 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | SNX18 | Sorting nexin. (624 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | CR201_G0048121 | PHF23 isoform 2. (264 aa) |
| | CR201_G0047047 | SMG1 isoform 2. (163 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa) |
| | NOD2 | NOD2 isoform 4. (1040 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | NUPR1 | NUPR1 isoform 3. (68 aa) |
| | CLN3 | Battenin. (438 aa) |
| | SMG1 | SMG1 isoform 8; Belongs to the PI3/PI4-kinase family. (2434 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (384 aa) |
| | EXOC1 | EXOC1 isoform 1. (912 aa) |
| | VDAC1 | VDAC1 isoform 1. (232 aa) |
| | STING1 | Transmembrane protein 173. (379 aa) |
| | ADRB2 | Adrenoceptor beta 2. (415 aa) |
| | ATP6V1G2 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | EHMT2 | EHMT2 isoform 5. (1267 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (275 aa) |
| | SESN1 | SESN1 isoform 1. (551 aa) |
| | TECPR1 | Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity); Belongs to the TECPR1 family. (1165 aa) |
| | NOD1 | NOD1 isoform 4. (953 aa) |
| | EXOC4 | EXOC4 isoform 2. (974 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | RHEB | RHEB isoform 1. (167 aa) |
| | ATP6V1B2 | V-type proton ATPase subunit B, brain isoform. (278 aa) |
| | LZTS1 | LZTS1 isoform 1. (544 aa) |
| | BNIP3L | BCL2 interacting protein 3 like. (219 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (465 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | UCHL1 | Ubiquitin carboxyl-terminal hydrolase. (223 aa) |
| | HTT | HTT isoform 1. (3130 aa) |
| | RUBCN | RUBCN isoform 2. (817 aa) |
| | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa) |
