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VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa) | ||||
CES1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (542 aa) | ||||
ENSPPYP00000008314 | Liver carboxylesterase 1-like isoform X1. (246 aa) | ||||
AKTIP | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). (293 aa) | ||||
TBC1D10B | TBC1 domain family member 10B. (812 aa) | ||||
CORO1A | Coronin; Belongs to the WD repeat coronin family. (445 aa) | ||||
CLN3 | Battenin. (438 aa) | ||||
EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa) | ||||
CORO7 | Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). (955 aa) | ||||
BAIAP3 | BAIAP3 isoform 3. (1072 aa) | ||||
SNX1 | Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa) | ||||
VPS13C | VPS13C isoform 1. (3448 aa) | ||||
TMEM87A | TMEM87A isoform 1. (562 aa) | ||||
VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) | ||||
ATG14 | Autophagy related 14. (492 aa) | ||||
SNX6 | Sorting nexin-6, N-terminally processed; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome- to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile call [...] (389 aa) | ||||
HEATR5A | HEATR5A isoform 1. (1951 aa) | ||||
PHETA1 | PH domain containing endocytic trafficking adaptor 1. (247 aa) | ||||
VPS29 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] (182 aa) | ||||
ARL1 | ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family. (181 aa) | ||||
MON2 | MON2 isoform 1. (1716 aa) | ||||
CCDC91 | Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. (441 aa) | ||||
GOLT1B | Golgi transport 1B. (138 aa) | ||||
VPS26B | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for car [...] (336 aa) | ||||
FAM160A2 | FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family. (950 aa) | ||||
DENND5A | DENND5A isoform 1. (1191 aa) | ||||
SLC66A2 | Solute carrier family 66 member 2. (271 aa) | ||||
TBC1D5 | TBC1D5 isoform 1. (784 aa) | ||||
PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa) | ||||
RAB6B | RAB6B, member RAS oncogene family. (208 aa) | ||||
GAK | GAK isoform 7. (1062 aa) | ||||
AP1AR | Adaptor related protein complex 1 associated regulatory protein. (302 aa) | ||||
RHOBTB3 | RHOBTB3 isoform 7. (548 aa) | ||||
DOP1A | DOPEY1 isoform 2. (2384 aa) | ||||
VPS52 | VPS52 isoform 4. (723 aa) | ||||
SNX8 | Sorting nexin 8. (465 aa) | ||||
LMTK2 | LMTK2 isoform 1. (1474 aa) | ||||
AP4M1 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa) | ||||
YKT6 | YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa) | ||||
VPS50 | VPS50 isoform 2. (964 aa) | ||||
WDR91 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis. (747 aa) | ||||
DENND2A | DENND2A isoform 4. (1009 aa) | ||||
HOOK3 | Protein Hook homolog 3 isoform X1. (804 aa) | ||||
SNX16 | Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity); Belongs to the sorting nexin family. (344 aa) | ||||
RGP1 | RGP1 homolog, RAB6A GEF complex partner 1. (391 aa) | ||||
RIC1 | RIC1 isoform 3. (1344 aa) | ||||
VPS13A | VPS13A isoform 1. (3118 aa) | ||||
RAB14 | Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell [...] (179 aa) | ||||
SNX12 | Sorting nexin 12. (162 aa) | ||||
FLNA | FLNA isoform 7. (2647 aa) | ||||
ERC1 | ELKS/RAB6-interacting/CAST family member 1. (1120 aa) | ||||
RAB5A | RAB5A, member RAS oncogene family. (215 aa) | ||||
PTPN23 | PTPN23 isoform 3. (1636 aa) | ||||
ARL8B | ADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). (185 aa) | ||||
TBC1D23 | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1 (By similarity). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outg [...] (699 aa) | ||||
RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa) | ||||
RBSN | Rabenosyn, RAB effector. (784 aa) | ||||
KIF1A | KIF1A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1554 aa) | ||||
PIKFYVE | PIKFYVE isoform 1. (2088 aa) | ||||
WASHC1 | WAS protein family homolog 1. (467 aa) | ||||
TGOLN2 | TGOLN2 isoform 3. (369 aa) | ||||
EHD3 | EHD3 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa) | ||||
HEATR5B | HEATR5B isoform 1. (1991 aa) | ||||
PREPL | Prolyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). (705 aa) | ||||
VPS54 | VPS54 subunit of GARP complex. (977 aa) | ||||
CR201_G0003005 | T0009947 isoform 1. (1278 aa) | ||||
GCC2 | GCC2 isoform 3. (1686 aa) | ||||
PHETA2 | PH domain containing endocytic trafficking adaptor 2. (259 aa) | ||||
GGA1 | GGA1 isoform 1. (634 aa) | ||||
TBC1D10A | TBC1 domain family member 10A. (503 aa) | ||||
CLTCL1 | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa) | ||||
TRAPPC10 | TRAPPC10 isoform 2. (1259 aa) | ||||
DOP1B | DOP1 leucine zipper like protein B. (2298 aa) | ||||
ARFRP1 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. (201 aa) | ||||
STX16 | STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa) | ||||
SNX5 | Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa) | ||||
CR201_G0019710 | KIF16B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1102 aa) | ||||
TBC1D17 | TBC1 domain family member 17. (648 aa) | ||||
TRIM27 | Tripartite motif containing 27. (513 aa) | ||||
HOOK2 | Hook microtubule tethering protein 2. (719 aa) | ||||
TMEM87B | Transmembrane protein 87B. (554 aa) | ||||
SNX2 | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (523 aa) | ||||
RAB29 | Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] (203 aa) | ||||
ENSPPYP00000000352 | annotation not available (88 aa) | ||||
STX6 | Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa) | ||||
KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (582 aa) | ||||
SORT1 | Sortilin. (789 aa) | ||||
EVI5 | Ecotropic viral integration site 5. (810 aa) | ||||
HOOK1 | Hook microtubule tethering protein 1. (728 aa) | ||||
EPS15 | Epidermal growth factor receptor pathway substrate 15. (896 aa) | ||||
SRSF10 | SRSF10 isoform 7. (262 aa) | ||||
VAMP3 | Vesicle associated membrane protein 3. (100 aa) | ||||
PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (347 aa) | ||||
KIF5B | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa) | ||||
Washc2 | WASH complex subunit 2; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation- promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] (1331 aa) | ||||
VPS26A | VPS26, retromer complex component A. (327 aa) | ||||
GBF1 | GBF1 isoform 1. (1855 aa) | ||||
VTI1A | Vesicle transport through interaction with t-SNAREs 1A. (217 aa) | ||||
CR201_G0031594 | TPCN2 isoform 7. (717 aa) | ||||
TBC1D10C | TBC1D10C isoform 5. (435 aa) | ||||
SNX32 | Sorting nexin; Involved in several stages of intracellular trafficking. (400 aa) | ||||
VPS51 | VPS51 isoform 3. (303 aa) | ||||
STX5 | STX5 isoform 1; Belongs to the syntaxin family. (355 aa) | ||||
RNF126 | RNF126 isoform 1. (240 aa) | ||||
PLEKHJ1 | PLEKHJ1 isoform 1. (149 aa) | ||||
STX10 | STX10 isoform 6; Belongs to the syntaxin family. (249 aa) | ||||
ANKRD27 | Ankyrin repeat domain-containing protein 27; May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (By similarity). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the fun [...] (893 aa) | ||||
CR201_G0029663 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (749 aa) | ||||
SYT4 | SYT4 isoform 1. (425 aa) | ||||
PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) | ||||
ENSPPYP00000010091 | annotation not available (152 aa) | ||||
SYT7 | SYT7 isoform 1. (400 aa) | ||||
SNF8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (279 aa) | ||||
CLTC | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa) | ||||
UBE2O | Ubiquitin conjugating enzyme E2 O. (1293 aa) | ||||
CR201_G0024013 | WIPI1 isoform 2. (251 aa) | ||||
BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa) | ||||
SPAG9 | Sperm associated antigen 9. (1307 aa) | ||||
ENSPPYP00000009265 | annotation not available (102 aa) | ||||
MYO1D | MYO1D isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa) | ||||
STX8 | STX8 isoform 2. (236 aa) | ||||
KIF1C | KIF1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1070 aa) | ||||
ANKFY1 | Ankyrin repeat and FYVE domain containing 1. (1170 aa) | ||||
SGSM2 | SGSM2 isoform 3. (1040 aa) | ||||
CR201_G0041408 | WDR81 isoform 4. (691 aa) | ||||
RILP | RILP isoform 2. (400 aa) | ||||
VPS53 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] (770 aa) |