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| | FMO4 | Dimethylaniline monooxygenase [N-oxide-forming]. (557 aa) |
| | FMO1 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) |
| | PTGS2 | PTGS2 isoform 1. (604 aa) |
| | SLC45A3 | SLC45A3 isoform 1. (552 aa) |
| | LPGAT1 | Lysophosphatidylglycerol acyltransferase 1. (370 aa) |
| | TWIST1 | Twist family bHLH transcription factor 1. (203 aa) |
| | PDK4 | Protein-serine/threonine kinase. (411 aa) |
| | CAV1 | Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa) |
| | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (531 aa) |
| | INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa) |
| | ERLIN2 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). (380 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa) |
| | FABP5 | FABP5 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa) |
| | NR4A3 | NR4A3 isoform 1. (626 aa) |
| | CR201_G0053199 | POTEB2 isoform 2. (305 aa) |
| | PDK3 | Protein-serine/threonine kinase. (415 aa) |
| | MID1IP1 | MID1IP1 isoform 1. (174 aa) |
| | ABCD1 | ABCD1 isoform 1. (710 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (677 aa) |
| | APOA4 | Apolipoprotein A4. (416 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (530 aa) |
| | FABP3 | Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa) |
| | TYSND1 | TYSND1 isoform 1. (565 aa) |
| | SIRT1 | SIRT1 isoform 1. (746 aa) |
| | ERLIN1 | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity). (341 aa) |
| | CPT1A | CPT1A isoform 3; Belongs to the carnitine/choline acetyltransferase family. (526 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (447 aa) |
| | DGAT2 | DGAT2 isoform 2. (445 aa) |
| | APOC3 | Apolipoprotein C3. (99 aa) |
| | ETFBKMT | Electron transfer flavoprotein subunit beta lysine methyltransferase. (262 aa) |
| | ABCD2 | ATP binding cassette subfamily D member 2. (740 aa) |
| | ENSPPYP00000005310 | annotation not available (135 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa) |
| | APPL2 | APPL2 isoform 1. (564 aa) |
| | ACACB | ACACB isoform 1. (2296 aa) |
| | SIRT4 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa) |
| | PIBF1 | PIBF1 isoform 1. (755 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | LONP2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family. (852 aa) |
| | MLYCD | T0129743 isoform 1. (381 aa) |
| | LOC112129374 | Putative ankyrin repeat domain-containing protein 26-like protein. (330 aa) |
| | ACADVL | ACADVL isoform 1. (650 aa) |
| | NCOR1 | NCOR1 isoform 1. (2467 aa) |
| | SREBF1 | SREBF1 isoform 2. (1153 aa) |
| | CR201_G0035225 | CCDC144A isoform 1. (482 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1863 aa) |
| | SOX9 | SRY-box transcription factor 9. (509 aa) |
| | GIP | GIP isoform 1. (124 aa) |
| | CR201_G0012267 | Protein-serine/threonine kinase. (406 aa) |
| | PLIN5 | Perilipin-5. (460 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | CEACAM1 | CEACAM1 isoform 2. (527 aa) |
| | APOC2 | Apolipoprotein C2. (101 aa) |
| | NR1H2 | NR1H2 isoform 11. (413 aa) |
| | CR201_G0043144 | ANKRD36 isoform 6. (119 aa) |
| | PANK2 | PANK2 isoform 5. (361 aa) |
| | AVP | AVP isoform 1; Belongs to the vasopressin/oxytocin family. (164 aa) |
| | TRIB3 | TRIB3 isoform 1. (358 aa) |
| | EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa) |
| | ENSPPYP00000012589 | Putative nuclear receptor corepressor 1-like protein NCOR1P1. (101 aa) |
| | PLA2G3 | PLA2G3 isoform 1. (505 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (474 aa) |
| | CR201_G0055029 | ANK_REP_REGION domain-containing protein. (402 aa) |
| | MTLN | LINC00116 isoform 1. (143 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | FABP1 | Fatty acid binding protein 1. (127 aa) |
| | ENSPPYP00000014180 | annotation not available (364 aa) |
| | CR201_G0045384 | POTEE isoform 2. (576 aa) |
| | INSIG2 | Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity). (216 aa) |
| | ABCB11 | ABCB11 isoform 1. (1321 aa) |
| | FMO2 | Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (535 aa) |
| | PDK1 | Protein-serine/threonine kinase. (463 aa) |
| | UGT1A3 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa) |
| | ERFE | ERFE isoform 3. (135 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma. (477 aa) |
| | TREX1 | Three prime repair exonuclease 1. (369 aa) |
| | SCAP | SCAP isoform 2. (1278 aa) |
| | SLC22A13 | SLC22A13 isoform 1. (551 aa) |
| | GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (244 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (798 aa) |
| | CD74 | CD74 isoform 2. (232 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa) |
| | MLXIPL | MLXIPL isoform 2. (879 aa) |
