STRINGSTRING
BECN2 BECN2 GNG4 GNG4 COQ8A COQ8A PIK3C2B PIK3C2B RGS1 RGS1 TPR TPR RGS8 RGS8 S100A6 S100A6 S100A10 S100A10 SYT6 SYT6 AP4B1 AP4B1 GNAT2 GNAT2 GNG5 GNG5 GNG12 GNG12 ENSPPYP00000001487 ENSPPYP00000001487 PIK3R3 PIK3R3 ZC3H12A ZC3H12A HPCA HPCA LCK LCK FGR FGR SYTL1 SYTL1 VPS13D VPS13D PIK3CD PIK3CD ERRFI1 ERRFI1 KCNAB2 KCNAB2 GNB1 GNB1 NMT2 NMT2 CUBN CUBN ENSPPYP00000002678 ENSPPYP00000002678 MSS51 MSS51 CR201_G0030294 CR201_G0030294 CDH23 CDH23 NRBF2 NRBF2 PSD PSD GFRA1 GFRA1 ATG2A ATG2A GNG3 GNG3 CTNND1 CTNND1 NUMA1 NUMA1 FOLR3 FOLR3 UVRAG UVRAG SYTL2 SYTL2 PICALM PICALM ST14 ST14 GNB3 GNB3 STYK1 STYK1 KRAS KRAS RACGAP1 RACGAP1 DCD DCD ARHGEF25 ARHGEF25 ATP23 ATP23 SOCS2 SOCS2 COQ5 COQ5 RNF10 RNF10 UBC UBC ULK1 ULK1 FARP1 FARP1 MCF2L MCF2L CDH24 CDH24 SEC23A SEC23A GNG2 GNG2 FERMT2 FERMT2 SOCS4 SOCS4 ATG14 ATG14 RGS6 RGS6 NUMB NUMB COQ6 COQ6 ATG2B ATG2B AKT1 AKT1 CR201_G0046277 CR201_G0046277 USP8 USP8 USP50 USP50 ENSPPYP00000007380 ENSPPYP00000007380 ENSPPYP00000007387 ENSPPYP00000007387 VPS13C VPS13C GRAMD2A GRAMD2A PML PML SNX33 SNX33 MFGE8 MFGE8 IQGAP1 IQGAP1 FES FES GNG13 GNG13 DNAJA3 DNAJA3 SOCS1 SOCS1 CR201_G0047042 CR201_G0047042 COQ7 COQ7 DOC2A DOC2A GNAO1 GNAO1 CDH8 CDH8 CDH11 CDH11 CDH5 CDH5 CARMIL2 CARMIL2 CDH3 CDH3 VAC14 VAC14 CDH15 CDH15 CR201_G0041408 CR201_G0041408 ALOX15 ALOX15 DLG4 DLG4 ACADVL ACADVL TNK1 TNK1 ALOX15B ALOX15B PIK3R6 PIK3R6 PIK3R5 PIK3R5 RNF112 RNF112 SARM1 SARM1 EPN3 EPN3 NMT1 NMT1 BECN1 BECN1 JUP JUP STAC2 STAC2 ENSPPYP00000009605 ENSPPYP00000009605 GNA13 GNA13 KPNA2 KPNA2 CR201_G0024013 CR201_G0024013 HID1 HID1 SOCS3 SOCS3 CYTH1 CYTH1 TEPSIN TEPSIN ASPSCR1 ASPSCR1 GNGT2 GNGT2 DOC2B DOC2B GNAL GNAL YES1 YES1 PIK3C3 PIK3C3 CDH20 CDH20 CDH7 CDH7 CDH19 CDH19 SOCS6 SOCS6 AZU1 AZU1 APC2 APC2 GNA11 GNA11 CR201_G0044254 CR201_G0044254 UBXN6 UBXN6 CR201_G0047202 CR201_G0047202 CR201_G0047202-2 CR201_G0047202-2 PDE4A PDE4A RTBDN RTBDN CR201_G0037390 CR201_G0037390 GRAMD1A GRAMD1A COQ8B COQ8B GNG8 GNG8 EHD2 EHD2 PLEKHA4 PLEKHA4 SNAP25 SNAP25 NDUFAF5 NDUFAF5 SNX5 SNX5 TGM3 TGM3 HCK HCK SLA2 SLA2 SRC SRC CDH22 CDH22 GNAS GNAS CDH26 CDH26 CDH4 CDH4 OSBPL2 OSBPL2 PTK6 PTK6 SRMS SRMS TIAM1 TIAM1 GNAZ GNAZ MTMR3 MTMR3 INPP5J INPP5J SYN3 SYN3 SOX10 SOX10 SCUBE1 SCUBE1 ARSA ARSA SHANK3 SHANK3 MAL MAL ZAP70 ZAP70 BCL2L11 BCL2L11 AAK1 AAK1 SOCS5 SOCS5 OSR1 OSR1 BIN1 BIN1 STK39 STK39 DNAJB2 DNAJB2 SERPINE2 SERPINE2 ENSPPYP00000014804 ENSPPYP00000014804 KIF1A KIF1A CCDC115 CCDC115 RAB7A RAB7A MGLL MGLL KALRN KALRN TAMM41 TAMM41 CISH CISH GNAI2 GNAI2 RHOA RHOA TDGF1 TDGF1 CTNNB1 CTNNB1 STAC STAC PIK3R4 PIK3R4 TF TF CR201_G0032561 CR201_G0032561 PIK3CB PIK3CB KCNAB1 KCNAB1 TNK2 TNK2 JAKMIP1 JAKMIP1 ENSPPYP00000016300 ENSPPYP00000016300 BST1 BST1 NAAA NAAA ENSPPYP00000016612 ENSPPYP00000016612 WDFY3 WDFY3 PPP3CA PPP3CA TRIO TRIO OTULINL OTULINL CDH18 CDH18 CR201_G0025391 CR201_G0025391 CDH10 CDH10 CDH9 CDH9 CDH6 CDH6 SNX18 SNX18 PIK3R1 PIK3R1 FER FER GFRA3 GFRA3 CTNNA1 CTNNA1 KCNIP1 KCNIP1 CBY3 CBY3 ARMC12 ARMC12 SNAP91 SNAP91 COQ3 COQ3 FYN FYN FRK FRK STXBP5 STXBP5 SYTL3 SYTL3 EZR EZR MICALL2 MICALL2 GNA12 GNA12 WIPI2 WIPI2 CYTH3 CYTH3 RAC1 RAC1 GNB2 GNB2 NCF1 NCF1 SNX10 SNX10 GNG11 GNG11 GNGT1 GNGT1 GNAT3 GNAT3 GNAI1 GNAI1 PIK3CG PIK3CG CAV2 CAV2 WNT2 WNT2 WDR91 WDR91 ENSPPYP00000020348 ENSPPYP00000020348 CDHR3 CDHR3 DEFB1 DEFB1 BLK BLK PTK2B PTK2B RB1CC1 RB1CC1 LYN LYN SNX16 SNX16 CDH17 CDH17 EMC2 EMC2 ANXA13 ANXA13 SLA SLA PTK2 PTK2 GML GML SCRIB SCRIB GBA2 GBA2 STOML2 STOML2 CNTFR CNTFR ANXA1 ANXA1 VPS13A VPS13A GNA14 GNA14 GNAQ GNAQ SYK SYK COQ4 COQ4 TOR1A TOR1A MITD1 MITD1 SYAP1 SYAP1 CNKSR2 CNKSR2 CDK16 CDK16 SYN1 SYN1 CR201_G0052920 CR201_G0052920 CR201_G0052915 CR201_G0052915 SYTL4 SYTL4 ENSPPYP00000023095 ENSPPYP00000023095 FMR1 FMR1 PIK3CA PIK3CA ESYT3 ESYT3 HIP1 HIP1 NPTX2 NPTX2 ESYT2 ESYT2 CR201_G0004084 CR201_G0004084 APC APC SOCS7 SOCS7 SNX9 SNX9 CRKL CRKL PLG PLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BECN2BECN2 isoform 1. (441 aa)
GNG4Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
COQ8ACOQ8A isoform 1. (647 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
RGS1RGS1 isoform 1. (209 aa)
TPRTPR isoform 1. (1308 aa)
RGS8Regulator of G protein signaling 8. (198 aa)
S100A6Protein S100; Belongs to the S-100 family. (90 aa)
S100A10S100A10 isoform 1; Belongs to the S-100 family. (222 aa)
SYT6SYT6 isoform 1. (509 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
GNG5Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG12Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSPPYP00000001487annotation not available (440 aa)
PIK3R3T0148502 isoform 1. (461 aa)
ZC3H12AZC3H12A isoform 1. (599 aa)
HPCAHPCA isoform 2. (193 aa)
LCKTyrosine-protein kinase. (487 aa)
FGRTyrosine-protein kinase. (529 aa)
SYTL1Synaptotagmin like 1. (550 aa)
VPS13DVPS13D isoform 1. (4302 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (461 aa)
KCNAB2KCNAB2 isoform 13. (367 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (340 aa)
NMT2Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (478 aa)
CUBNCUBN isoform 1. (3507 aa)
ENSPPYP00000002678annotation not available (281 aa)
MSS51MSS51 mitochondrial translational activator. (460 aa)
CR201_G0030294CDH23 isoform 6. (250 aa)
CDH23CDH23 isoform 1. (2498 aa)
NRBF2Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity); Belongs to the NRBF family. (287 aa)
PSDPSD isoform 2. (982 aa)
GFRA1GDNF family receptor alpha; Belongs to the GDNFR family. (462 aa)
ATG2AATG2A isoform 1. (1932 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CTNND1CTNND1 isoform 19. (968 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2114 aa)
FOLR3FOLR3 isoform 2. (257 aa)
UVRAGUV radiation resistance associated. (699 aa)
SYTL2SYTL2 isoform 4. (935 aa)
PICALMPICALM isoform 11. (686 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
GNB3G protein subunit beta 3. (340 aa)
STYK1Serine/threonine/tyrosine kinase 1. (422 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
DCDDCD isoform 1. (110 aa)
ARHGEF25ARHGEF25 isoform 6. (473 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (244 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (304 aa)
RNF10RNF10 isoform 1. (725 aa)
UBCUBC isoform 2. (625 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa)
FARP1FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). (1045 aa)
MCF2LMCF2L isoform 10. (1211 aa)
CDH24CDH24 isoform 3; Cadherins are calcium-dependent cell adhesion proteins. (819 aa)
SEC23AProtein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (713 aa)
GNG2Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). (71 aa)
FERMT2FERMT2 isoform 1. (623 aa)
SOCS4Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). (373 aa)
ATG14Autophagy related 14. (492 aa)
RGS6Regulator of G protein signaling 6. (455 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
COQ6COQ6 isoform 4. (393 aa)
ATG2BATG2B isoform 1. (2060 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
CR201_G0046277Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (143 aa)
USP8USP8 isoform 3; Belongs to the peptidase C19 family. (1118 aa)
USP50USP50 isoform 1. (365 aa)
ENSPPYP00000007380annotation not available (435 aa)
ENSPPYP00000007387annotation not available (61 aa)
VPS13CVPS13C isoform 1. (3448 aa)
GRAMD2AGRAM domain containing 2A. (354 aa)
PMLPML isoform 4. (869 aa)
SNX33Sorting nexin. (572 aa)
MFGE8MFGE8 isoform 3. (384 aa)
IQGAP1IQGAP1 isoform 1. (1656 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
GNG13GNG13 isoform 1. (67 aa)
DNAJA3DNAJA3 isoform 2. (464 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
CR201_G0047042Transmembrane channel-like protein. (513 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
DOC2ADouble C2-like domain-containing protein. (398 aa)
GNAO1GNAO1 isoform 1. (354 aa)
CDH8CDH8 isoform 3; Cadherins are calcium-dependent cell adhesion proteins. (695 aa)
CDH11CDH11 isoform 6; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
CDH5CDH5 isoform 2; Cadherins are calcium-dependent cell adhesion proteins. (781 aa)
CARMIL2CARMIL2 isoform 1. (1395 aa)
CDH3CDH3 isoform 2; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
CDH15CDH15 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (676 aa)
CR201_G0041408WDR81 isoform 4. (691 aa)
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (662 aa)
DLG4DLG4 isoform 3; Belongs to the MAGUK family. (690 aa)
ACADVLACADVL isoform 1. (650 aa)
TNK1TNK1 isoform 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (596 aa)
ALOX15BALOX15B isoform 2. (676 aa)
PIK3R6PIK3R6 isoform 2. (696 aa)
PIK3R5PIK3R5 isoform 10. (883 aa)
RNF112RNF112 isoform 1. (632 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
EPN3EPN3 isoform 1. (638 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. (517 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa)
JUPJUP isoform 1. (670 aa)
STAC2SH3 and cysteine rich domain 2. (411 aa)
ENSPPYP00000009605annotation not available (424 aa)
GNA13G protein subunit alpha 13. (377 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (526 aa)
CR201_G0024013WIPI1 isoform 2. (251 aa)
HID1HID1 isoform 2. (766 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
CYTH1CYTH1 isoform 4. (399 aa)
TEPSINTEPSIN isoform 1. (492 aa)
ASPSCR1ASPSCR1 isoform 2. (553 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
DOC2BDOC2B isoform 2. (301 aa)
GNALGNAL isoform 3. (381 aa)
YES1Tyrosine-protein kinase. (485 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
CDH20CDH20 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (712 aa)
CDH7CDH7 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (724 aa)
CDH19CDH19 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
SOCS6Suppressor of cytokine signaling 6; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine- phosphorylated receptor (By similarity). (535 aa)
AZU1AZU1 isoform 1. (250 aa)
APC2APC2 isoform 1. (2148 aa)
GNA11GNA11 isoform 1. (358 aa)
CR201_G0044254GNA15 isoform 1. (287 aa)
UBXN6UBXN6 isoform 3. (436 aa)
CR201_G0047202MUC16 isoform 3. (684 aa)
CR201_G0047202-2MUC16 isoform 1. (4354 aa)
PDE4APhosphodiesterase. (789 aa)
RTBDNRTBDN isoform 2. (229 aa)
CR201_G0037390PIK3R2 isoform 1. (641 aa)
GRAMD1AGRAMD1A isoform 3. (750 aa)
COQ8BCOQ8B isoform 1. (644 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
EHD2EHD2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (605 aa)
PLEKHA4PLEKHA4 isoform 2. (725 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. (206 aa)
NDUFAF5Arginine-hydroxylase NDUFAF5, mitochondrial; Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT- ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity. (459 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
TGM3TGM3 isoform 1. (693 aa)
HCKTyrosine-protein kinase. (449 aa)
SLA2Src like adaptor 2. (261 aa)
SRCTyrosine-protein kinase. (553 aa)
CDH22CDH22 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (690 aa)
GNASGNAS isoform 2. (1037 aa)
CDH26CDH26 isoform 5. (886 aa)
CDH4CDH4 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (862 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
PTK6Tyrosine-protein kinase. (451 aa)
SRMSTyrosine-protein kinase. (489 aa)
TIAM1TIAM1 isoform 1. (1591 aa)
GNAZGNAZ isoform 1. (350 aa)
MTMR3Myotubularin related protein 3. (1198 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1007 aa)
SYN3SYN3 isoform 1. (580 aa)
SOX10SOX10 isoform 2. (436 aa)
SCUBE1SCUBE1 isoform 1. (983 aa)
ARSAARSA isoform 3. (443 aa)
SHANK3SHANK3 isoform 2. (1202 aa)
MALMal, T cell differentiation protein. (153 aa)
ZAP70Tyrosine-protein kinase. (559 aa)
BCL2L11BCL2L11 isoform 4. (138 aa)
AAK1AAK1 isoform 9. (1306 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
OSR1OSR1 isoform 1. (265 aa)
BIN1BIN1 isoform 9. (517 aa)
STK39STK39 isoform 1. (546 aa)
DNAJB2DNAJB2 isoform 1. (298 aa)
SERPINE2SERPINE2 isoform 5; Belongs to the serpin family. (409 aa)
ENSPPYP00000014804Teratocarcinoma-derived growth factor 1-like. (155 aa)
KIF1AKIF1A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1554 aa)
CCDC115CCDC115 isoform 1. (180 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa)
MGLLMonoglyceride lipase. (313 aa)
KALRNKALRN isoform 1. (2858 aa)
TAMM41TAMM41 isoform 3. (151 aa)
CISHCytokine inducible SH2 containing protein. (258 aa)
GNAI2GNAI2 isoform 1. (303 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa)
TDGF1TDGF1 isoform 2. (182 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
STACSH3 and cysteine rich domain. (402 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa)
TFTF isoform 1; Belongs to the transferrin family. (703 aa)
CR201_G0032561ESYT3 isoform 2. (622 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
TNK2TNK2 isoform 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
JAKMIP1Janus kinase and microtubule-interacting protein 1 isoform X1. (652 aa)
ENSPPYP00000016300annotation not available (120 aa)
BST1BST1 isoform 4. (284 aa)
NAAANAAA isoform 1; Belongs to the acid ceramidase family. (418 aa)
ENSPPYP00000016612annotation not available (511 aa)
WDFY3WDFY3 isoform 1. (3520 aa)
PPP3CASerine/threonine-protein phosphatase. (514 aa)
TRIOTRIO isoform 3. (3011 aa)
OTULINLFAM105A isoform 1. (360 aa)
CDH18CDH18 isoform 2; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
CR201_G0025391CDH12 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (793 aa)
CDH10CDH10 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (788 aa)
CDH9CDH9 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (702 aa)
CDH6CDH6 isoform 2; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
SNX18Sorting nexin. (624 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
GFRA3GFRA3 isoform 1. (360 aa)
CTNNA1CTNNA1 isoform 1. (905 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (227 aa)
CBY3CBY3 isoform 1. (135 aa)
ARMC12Armadillo repeat containing 12. (367 aa)
SNAP91SNAP91 isoform 3. (908 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (369 aa)
FYNTyrosine-protein kinase. (537 aa)
FRKTyrosine-protein kinase. (505 aa)
STXBP5STXBP5 isoform 4. (1112 aa)
SYTL3Synaptotagmin like 3. (610 aa)
EZREZR isoform 1. (586 aa)
MICALL2MICALL2 isoform 9. (905 aa)
GNA12GNA12 isoform 1. (381 aa)
WIPI2WIPI2 isoform 1. (429 aa)
CYTH3CYTH3 isoform 1. (399 aa)
RAC1Rac family small GTPase 1. (211 aa)
GNB2GNB2 isoform 1. (340 aa)
NCF1NCF1 isoform 3. (364 aa)
SNX10Sorting nexin 10. (201 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAT3GNAT3 isoform 1. (355 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa)
PIK3CGPIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. (1102 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WDR91WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis. (747 aa)
ENSPPYP00000020348annotation not available (364 aa)
CDHR3CDHR3 isoform 2. (885 aa)
DEFB1DEFB1 isoform 1. (68 aa)
BLKTyrosine-protein kinase. (505 aa)
PTK2BPTK2B isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
RB1CC1RB1CC1 isoform 1. (1594 aa)
LYNTyrosine-protein kinase. (512 aa)
SNX16Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity); Belongs to the sorting nexin family. (344 aa)
CDH17CDH17 isoform 1. (832 aa)
EMC2ER membrane protein complex subunit 2; Belongs to the EMC2 family. (297 aa)
ANXA13Annexin. (355 aa)
SLASrc like adaptor. (276 aa)
PTK2PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
GMLGML isoform 2. (158 aa)
SCRIBSCRIB isoform 2. (1472 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (927 aa)
STOML2STOML2 isoform 3. (356 aa)
CNTFRCNTFR isoform 5. (475 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
VPS13AVPS13A isoform 1. (3118 aa)
GNA14G protein subunit alpha 14. (355 aa)
GNAQG protein subunit alpha q. (359 aa)
SYKTyrosine-protein kinase. (588 aa)
COQ4Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (265 aa)
TOR1ATorsin. (364 aa)
MITD1MIT domain-containing protein. (215 aa)
SYAP1SYAP1 isoform 1. (352 aa)
CNKSR2CNKSR2 isoform 1. (1031 aa)
CDK16CDK16 isoform 3. (496 aa)
SYN1SYN1 isoform 2. (645 aa)
CR201_G0052920GRIPAP1 isoform 14. (643 aa)
CR201_G0052915WDR45 isoform 17. (182 aa)
SYTL4SYTL4 isoform 2. (672 aa)
ENSPPYP00000023095annotation not available (68 aa)
FMR1Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] (590 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
ESYT3ESYT3 isoform 7. (243 aa)
HIP1HIP1 isoform 5. (830 aa)
NPTX2NPTX2 isoform 1. (260 aa)
ESYT2Extended synaptotagmin 2. (927 aa)
CR201_G0004084LPA isoform 1. (1113 aa)
APCAdenomatous polyposis coli protein isoform X2. (2861 aa)
SOCS7SOCS7 isoform 2. (578 aa)
SNX9Sorting nexin. (618 aa)
CRKLCRKL isoform 1. (251 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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