STRINGSTRING
PDPN PDPN LEPR LEPR ENSPPYP00000024753 ENSPPYP00000024753 IL6R IL6R TNFRSF14 TNFRSF14 CR201_G0056480 CR201_G0056480 IL9R IL9R ENSPPYP00000023282 ENSPPYP00000023282 IL13RA1 IL13RA1 IL13RA2 IL13RA2 CHRDL1 CHRDL1 CXCR3 CXCR3 IL2RG IL2RG PLP2 PLP2 ENSPPYP00000022456 ENSPPYP00000022456 CR201_G0055887 CR201_G0055887 ENSPPYP00000022454 ENSPPYP00000022454 TRAF2 TRAF2 ENG ENG TGFBR1 TGFBR1 CER1 CER1 CNTFR CNTFR COPS5 COPS5 CR201_G0030385 CR201_G0030385 ENSPPYP00000020180 ENSPPYP00000020180 CD36 CD36 SOSTDC1 SOSTDC1 BMPER BMPER CCR6 CCR6 IFNGR1 IFNGR1 IL22RA2 IL22RA2 IL20RA IL20RA CD109 CD109 IL17F IL17F SCUBE3 SCUBE3 IL12B IL12B CD74 CD74 CSF1R CSF1R IL6ST IL6ST IL31RA IL31RA GHR GHR OSMR OSMR LIFR LIFR PRLR PRLR BMPR1B BMPR1B KIT KIT CCR5 CCR5 CCR2 CCR2 NRROS NRROS CHRD CHRD IL12A IL12A IL20RB IL20RB ACKR4 ACKR4 TGFBR2 TGFBR2 CCR4 CCR4 CX3CR1 CX3CR1 CCR8 CCR8 ACKR2 ACKR2 CCR9 CCR9 CXCR6 CXCR6 XCR1 XCR1 CCR3 CCR3 CCRL2 CCRL2 HYAL2 HYAL2 IL5RA IL5RA ACKR3 ACKR3 CXCR1 CXCR1 CXCR2 CXCR2 NRP2 NRP2 BMPR2 BMPR2 ITGAV ITGAV ACVR1 ACVR1 CXCR4 CXCR4 PXDN PXDN IL1RN IL1RN IL36RN IL36RN IL18R1 IL18R1 IL1RL1 IL1RL1 IL2RB IL2RB IFNAR1 IFNAR1 CR201_G0027342 CR201_G0027342 SPINT3 SPINT3 GDF5 GDF5 ZFP36 ZFP36 NLRP7 NLRP7 LTBP4 LTBP4 CRLF1 CRLF1 CR201_G0037393 CR201_G0037393 IL1R1 IL1R1 IL1R2 IL1R2 IL27RA IL27RA ENSPPYP00000010539 ENSPPYP00000010539 ELANE ELANE TNFRSF11A TNFRSF11A TWSG1 TWSG1 TMC8 TMC8 TCAP TCAP CCR7 CCR7 CCR10 CCR10 SOST SOST WFIKKN2 WFIKKN2 NOG NOG TRIM16 TRIM16 VASN VASN WFIKKN1 WFIKKN1 THBS1 THBS1 GREM1 GREM1 TGFB3 TGFB3 ACVRL1 ACVRL1 CD4 CD4 TNFRSF1A TNFRSF1A CXCR5 CXCR5 IL10RA IL10RA FZD4 FZD4 TSKU TSKU LRRC32 LRRC32 CHRDL2 CHRDL2 IL18BP IL18BP LTBP3 LTBP3 BMPR1A BMPR1A NRP1 NRP1 UCMA UCMA IL2RA IL2RA CR201_G0025591 CR201_G0025591 TNFRSF9 TNFRSF9 PARK7 PARK7 TNFRSF1B TNFRSF1B NBL1 NBL1 IL22RA1 IL22RA1 CSF3R CSF3R GREM2 GREM2 KLHL20 KLHL20 ACKR1 ACKR1 HAX1 HAX1 HJV HJV TGFBR3 TGFBR3 GBP1 GBP1 IL12RB2 IL12RB2 IL23R IL23R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDPNPDPN isoform 1. (236 aa)
LEPRLeptin receptor. (1165 aa)
ENSPPYP00000024753annotation not available (336 aa)
IL6RIL6R isoform 2. (499 aa)
TNFRSF14TNFRSF14 isoform 1. (136 aa)
CR201_G0056480IL3RA isoform 1. (158 aa)
IL9RInterleukin 9 receptor. (342 aa)
ENSPPYP00000023282annotation not available (191 aa)
IL13RA1IL13RA1 isoform 1. (367 aa)
IL13RA2IL13RA2 isoform 2. (388 aa)
CHRDL1CHRDL1 isoform 4. (456 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
IL2RGIL2RG isoform 2. (369 aa)
PLP2PLP2 isoform 1. (303 aa)
ENSPPYP00000022456annotation not available (214 aa)
CR201_G0055887CSF2RA isoform 11. (293 aa)
ENSPPYP00000022454annotation not available (156 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ENGENG isoform 3. (668 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
CER1CER1 isoform 1. (215 aa)
CNTFRCNTFR isoform 5. (475 aa)
COPS5COP9 signalosome subunit 5. (334 aa)
CR201_G0030385KCP isoform 4. (810 aa)
ENSPPYP00000020180annotation not available (295 aa)
CD36CD36 isoform 15; Belongs to the CD36 family. (472 aa)
SOSTDC1Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Enhances Wnt signaling and inhibits TGF-beta signaling. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction (By similarity). (206 aa)
BMPERBMPER isoform 1. (376 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa)
IFNGR1IFNGR1 isoform 1. (489 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
IL20RAInterleukin 20 receptor subunit alpha. (553 aa)
CD109CD109 isoform 3. (1445 aa)
IL17FIL17F isoform 1. (163 aa)
SCUBE3SCUBE3 isoform 1. (897 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CD74CD74 isoform 2. (232 aa)
CSF1RCSF1R isoform 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (898 aa)
IL6STIL6ST isoform 1. (935 aa)
IL31RAIL31RA isoform 5. (764 aa)
GHRGrowth hormone receptor. (638 aa)
OSMROSMR isoform 2. (978 aa)
LIFRLIFR isoform 1. (1097 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (492 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (770 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
CCR2CCR2 isoform 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
NRROSNRROS isoform 1. (692 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (938 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IL20RBIL20RB isoform 2. (229 aa)
ACKR4Atypical chemokine receptor 4. (350 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ACKR2ACKR2 isoform 3; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CXCR6C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (342 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CCR3CCR3 isoform 2; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCRL2CCRL2 isoform 3; Belongs to the G-protein coupled receptor 1 family. (345 aa)
HYAL2Hyaluronidase. (473 aa)
IL5RAIL5RA isoform 4. (422 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CXCR1C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ITGAVITGAV isoform 2; Belongs to the integrin alpha chain family. (1041 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
PXDNPXDN isoform 2. (1557 aa)
IL1RNInterleukin-1. (159 aa)
IL36RNInterleukin-1. (155 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
IL1RL1IL1RL1 isoform 3. (328 aa)
IL2RBIL2RB isoform 1. (462 aa)
IFNAR1IFNAR1 isoform 2. (519 aa)
CR201_G0027342T0093957 isoform 2. (541 aa)
SPINT3Serine peptidase inhibitor, Kunitz type 3. (89 aa)
GDF5Growth differentiation factor 5. (501 aa)
ZFP36ZFP36 isoform 1. (216 aa)
NLRP7NLRP7 isoform 8. (1002 aa)
LTBP4LTBP4 isoform 2. (1582 aa)
CRLF1CRLF1 isoform 2. (383 aa)
CR201_G0037393IL12RB1 isoform 1. (531 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
IL1R2IL1R2 isoform 2. (390 aa)
IL27RAIL27RA isoform 1. (548 aa)
ENSPPYP00000010539annotation not available (168 aa)
ELANEELANE isoform 1; Belongs to the peptidase S1 family. (267 aa)
TNFRSF11ATNFRSF11A isoform 5. (616 aa)
TWSG1Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity); Belongs to the twisted gastrulation protei [...] (223 aa)
TMC8Transmembrane channel-like protein. (726 aa)
TCAPTCAP isoform 1. (167 aa)
CCR7CCR7 isoform 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (365 aa)
SOSTSOST isoform 1. (245 aa)
WFIKKN2WFIKKN2 isoform 1. (575 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TRIM16E3 ubiquitin-protein ligase TRIM16; E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative str [...] (564 aa)
VASNVASN isoform 1. (673 aa)
WFIKKN1WFIKKN1 isoform 1. (547 aa)
THBS1Thrombospondin 1. (1170 aa)
GREM1Gremlin. (184 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ACVRL1Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well (By similarity). (503 aa)
CD4CD4 isoform 2. (414 aa)
TNFRSF1ATNFRSF1A isoform 2. (454 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
FZD4FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
LRRC32Transforming growth factor beta activator LRRC32; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (By similarity). Controls activation of TGF-beta-1 (TGFB1) on the surface of activa [...] (661 aa)
CHRDL2CHRDL2 isoform 4. (452 aa)
IL18BPInterleukin 18 binding protein. (194 aa)
LTBP3LTBP3 isoform 3. (1245 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
UCMAUCMA isoform 1. (105 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
CR201_G0025591TNFRSF14 isoform 6. (206 aa)
TNFRSF9TNF receptor superfamily member 9. (254 aa)
PARK7PARK7 isoform 1. (189 aa)
TNFRSF1BTNFRSF1B isoform 2. (455 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (181 aa)
IL22RA1IL22RA1 isoform 1. (552 aa)
CSF3RCSF3R isoform 3. (834 aa)
GREM2Gremlin. (168 aa)
KLHL20Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (582 aa)
ACKR1ACKR1 isoform 1. (336 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
HJVHFE2 isoform 3. (425 aa)
TGFBR3TGFBR3 isoform 1. (859 aa)
GBP1Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). (590 aa)
IL12RB2IL12RB2 isoform 2. (825 aa)
IL23RInterleukin 23 receptor. (629 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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