STRINGSTRING
CDK5R1 CDK5R1 MBOAT7 MBOAT7 SUN2 SUN2 PEX13 PEX13 RTN4 RTN4 CCDC141 CCDC141 COL3A1 COL3A1 CDK5R2 CDK5R2 ARL13B ARL13B ROBO1 ROBO1 FEZF2 FEZF2 RHOA RHOA CTNNB1 CTNNB1 BMERB1 BMERB1 ADGRG1 ADGRG1 ENSPPYP00000008060 ENSPPYP00000008060 FOXB1 FOXB1 PSEN1 PSEN1 SYNE2 SYNE2 NKX2-1 NKX2-1 FOXG1 FOXG1 PEX5 PEX5 DRD2 DRD2 DIXDC1 DIXDC1 SLIT1 SLIT1 ZMIZ1 ZMIZ1 CR201_G0036525 CR201_G0036525 CXCL12 CXCL12 HTR6 HTR6 LRP8 LRP8 DAB1 DAB1 TNR TNR CNTN2 CNTN2 SRGAP2 SRGAP2 DISC1 DISC1 SLIT2 SLIT2 DRD1 DRD1 MDGA1 MDGA1 SRF SRF EFHC1 EFHC1 NR2E1 NR2E1 ENSPPYP00000019378 ENSPPYP00000019378 EGFR EGFR GLI3 GLI3 RELN RELN LAMB1 LAMB1 CDK5 CDK5 NRG1 NRG1 FUT10 FUT10 DAB2IP DAB2IP CR201_G0013169 CR201_G0013169 DCX DCX FGF13 FGF13 LHX6 LHX6 LRRK2 LRRK2 P2RY12 P2RY12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
MBOAT7MBOAT7 isoform 2; Belongs to the membrane-bound acyltransferase family. (471 aa)
SUN2Sad1 and UNC84 domain containing 2. (721 aa)
PEX13Peroxisomal biogenesis factor 13. (403 aa)
RTN4Reticulon. (1192 aa)
CCDC141CCDC141 isoform 5. (1450 aa)
COL3A1COL3A1 isoform 2. (1394 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
ARL13BARL13B isoform 4. (428 aa)
ROBO1ROBO1 isoform 6. (1612 aa)
FEZF2FEZ family zinc finger 2. (460 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
BMERB1bMERB domain-containing protein 1. (158 aa)
ADGRG1ADGRG1 isoform 22; Belongs to the G-protein coupled receptor 2 family. (687 aa)
ENSPPYP00000008060annotation not available (65 aa)
FOXB1FOXB1 isoform 1. (325 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa)
SYNE2SYNE2 isoform 1. (6862 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
FOXG1FOXG1 isoform 8. (440 aa)
PEX5Peroxisomal biogenesis factor 5. (556 aa)
DRD2DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. (461 aa)
DIXDC1DIX domain containing 1. (683 aa)
SLIT1Slit guidance ligand 1. (1578 aa)
ZMIZ1ZMIZ1 isoform 2. (1002 aa)
CR201_G0036525NRG3 isoform 1. (396 aa)
CXCL12CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
HTR6HTR6 isoform 1; Belongs to the G-protein coupled receptor 1 family. (440 aa)
LRP8LRP8 isoform 1. (955 aa)
DAB1DAB adaptor protein 1. (555 aa)
TNRTNR isoform 1. (1309 aa)
CNTN2CNTN2 isoform 10. (1039 aa)
SRGAP2SLIT-ROBO Rho GTPase activating protein 2. (1071 aa)
DISC1DISC1 scaffold protein. (840 aa)
SLIT2SLIT2 isoform 5. (1503 aa)
DRD1DRD1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
MDGA1MDGA1 isoform 1. (956 aa)
SRFSerum response factor. (508 aa)
EFHC1EFHC1 isoform 14. (636 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
ENSPPYP00000019378annotation not available (968 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GLI3GLI3 isoform 3. (1580 aa)
RELNRELN isoform 2. (3292 aa)
LAMB1LAMB1 isoform 1. (1786 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
NRG1NRG1 isoform 10. (692 aa)
FUT10Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family. (481 aa)
DAB2IPDAB2IP isoform 2. (1130 aa)
CR201_G0013169ARX isoform 4. (297 aa)
DCXDCX isoform 10. (446 aa)
FGF13Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa)
LHX6LHX6 isoform 4. (392 aa)
LRRK2LRRK2 isoform 3. (1560 aa)
P2RY12Purinergic receptor P2Y12. (342 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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