STRINGSTRING
CORO1C CORO1C SSH1 SSH1 TRPV4 TRPV4 ARPC3 ARPC3 TESC TESC CR201_G0000922 CR201_G0000922 NME2 NME2 STX2 STX2 SPATA13 SPATA13 WASF3 WASF3 ARHGEF7 ARHGEF7 AJUBA AJUBA CARMIL3 CARMIL3 FERMT2 FERMT2 SYNE2 SYNE2 PLEK2 PLEK2 EVL EVL CDC42BPB CDC42BPB AKT1 AKT1 CYFIP1 CYFIP1 ACTC1 ACTC1 SNX1 SNX1 CSPG4 CSPG4 PSTPIP1 PSTPIP1 ENSPPYP00000007589 ENSPPYP00000007589 ENSPPYP00000007639 ENSPPYP00000007639 ENSPPYP00000007684 ENSPPYP00000007684 CR201_G0014777 CR201_G0014777 ARPIN ARPIN MEFV MEFV CORO1A CORO1A STX4 STX4 CARMIL2 CARMIL2 MTSS1L MTSS1L BCAR1 BCAR1 CR201_G0048356 CR201_G0048356 TUBB3 TUBB3 MYH10 MYH10 FLOT2 FLOT2 CR201_G0033575 CR201_G0033575 CORO6 CORO6 BAIAP2 BAIAP2 P4HB P4HB RAC3 RAC3 SRCIN1 SRCIN1 IGF2BP1 IGF2BP1 ABI3 ABI3 PPP1R9B PPP1R9B ITGB3 ITGB3 ROCK1 ROCK1 SLC39A6 SLC39A6 APC2 APC2 DNM2 DNM2 ENSPPYP00000010854 ENSPPYP00000010854 MYO9B MYO9B CD177 CD177 VASP VASP KPTN KPTN SPEF1 SPEF1 PLCG1 PLCG1 ITSN1 ITSN1 NF2 NF2 RAC2 RAC2 PARVB PARVB CAPG CAPG ACTG2 ACTG2 ANTXR1 ANTXR1 CCDC88A CCDC88A PLEKHH2 PLEKHH2 NRBP1 NRBP1 LOC100449402 LOC100449402 ACTR3 ACTR3 ENSPPYP00000014325 ENSPPYP00000014325 DPP4 DPP4 FAP FAP NCKAP1 NCKAP1 ITGAV ITGAV ALS2 ALS2 ABI2 ABI2 RAPH1 RAPH1 ARPC2 ARPC2 VIL1 VIL1 ENSPPYP00000014963 ENSPPYP00000014963 FGD5 FGD5 PLXND1 PLXND1 MYLK MYLK ARHGAP31 ARHGAP31 BRK1 BRK1 TWF2 TWF2 RHOA RHOA CTNNB1 CTNNB1 CLRN1 CLRN1 APBB2 APBB2 RUFY3 RUFY3 PTPN13 PTPN13 PKD2 PKD2 UNC5C UNC5C KLHL2 KLHL2 PALLD PALLD SH3RF1 SH3RF1 SORBS2 SORBS2 FAT1 FAT1 MYO10 MYO10 ENSPPYP00000017278 ENSPPYP00000017278 IQGAP2 IQGAP2 MCC MCC PDLIM4 PDLIM4 CTNNA1 CTNNA1 DPYSL3 DPYSL3 ABLIM3 ABLIM3 DBN1 DBN1 DUSP22 DUSP22 ENSPPYP00000018135 ENSPPYP00000018135 NEDD9 NEDD9 CARMIL1 CARMIL1 AIF1 AIF1 FGD2 FGD2 WASF1 WASF1 TIAM2 TIAM2 ACTB ACTB FSCN1 FSCN1 RAC1 RAC1 LIMK1 LIMK1 MYO1G MYO1G DBNL DBNL WASL WASL FSCN3 FSCN3 PODXL PODXL CDK5 CDK5 PTK2B PTK2B STMN2 STMN2 PABPC1 PABPC1 SCRIB SCRIB TESK1 TESK1 DOCK8 DOCK8 ABITRAM ABITRAM GSN GSN TSC1 TSC1 ENSPPYP00000022338 ENSPPYP00000022338 NHS NHS DMD DMD CR201_G0042601-2 CR201_G0042601-2 FGD1 FGD1 GDPD2 GDPD2 AMOT AMOT ARHGEF6 ARHGEF6 ENSPPYP00000023282 ENSPPYP00000023282 PIK3CA PIK3CA ILK ILK ARAP3 ARAP3 APC APC ITGB1BP1 ITGB1BP1 FLOT1 FLOT1 CAPRIN1 CAPRIN1 SNX2 SNX2 CR201_G0010942 CR201_G0010942 CR201_G0011084 CR201_G0011084 PARVA PARVA APBB1 APBB1 INPPL1 INPPL1 PAK1 PAK1 RDX RDX PTPRO PTPRO FGD4 FGD4 AVIL AVIL RAB3IP RAB3IP KITLG KITLG ACTA1 ACTA1 CDC42BPA CDC42BPA ENAH ENAH SRGAP2 SRGAP2 ARPC5 ARPC5 SCYL3 SCYL3 HAX1 HAX1 RAB13 RAB13 PIP5K1A PIP5K1A CTTNBP2NL CTTNBP2NL PKN2 PKN2 ANGPTL3 ANGPTL3 PHACTR4 PHACTR4 CR201_G0042601 CR201_G0042601 SLC9A1 SLC9A1 EPHA2 EPHA2 PDPN PDPN PLEKHG5 PLEKHG5 APBB1IP APBB1IP ABI1 ABI1 ITGB1 ITGB1 CTNNA3 CTNNA3 ACTA2 ACTA2 PLCE1 PLCE1 FGD6 FGD6 ABLIM1 ABLIM1 SHTN1 SHTN1 CTTN CTTN CORO1B CORO1B CFL1 CFL1 FAM89B FAM89B STX3 STX3 CTNND1 CTNND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CORO1CCoronin; Belongs to the WD repeat coronin family. (434 aa)
SSH1SSH1 isoform 1. (1004 aa)
TRPV4TRPV4 isoform 2; Belongs to the transient receptor (TC 1.A.4) family. (699 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (168 aa)
TESCTESC isoform 2. (214 aa)
CR201_G0000922PXN isoform 2; Belongs to the paxillin family. (381 aa)
NME2Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] (152 aa)
STX2STX2 isoform 2; Belongs to the syntaxin family. (263 aa)
SPATA13SPATA13 isoform 1. (1274 aa)
WASF3WASP family member 3. (499 aa)
ARHGEF7ARHGEF7 isoform 7. (803 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (538 aa)
CARMIL3CARMIL3 isoform 1. (1370 aa)
FERMT2FERMT2 isoform 1. (623 aa)
SYNE2SYNE2 isoform 1. (6862 aa)
PLEK2PLEK2 isoform 1. (353 aa)
EVLEna/VASP-like protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization (By similarity). (422 aa)
CDC42BPBCDC42BPB isoform 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1617 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
SNX1Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa)
CSPG4Uncharacterized protein. (2071 aa)
PSTPIP1PSTPIP1 isoform 5. (383 aa)
ENSPPYP00000007589LOW QUALITY PROTEIN: chondroitin sulfate proteoglycan 4-like. (75 aa)
ENSPPYP00000007639annotation not available (73 aa)
ENSPPYP00000007684annotation not available (127 aa)
CR201_G0014777CIB1 isoform 1. (190 aa)
ARPINC15orf38-AP3S2 isoform 2. (91 aa)
MEFVMEFV isoform 4. (780 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (445 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
CARMIL2CARMIL2 isoform 1. (1395 aa)
MTSS1LMTSS1L isoform 1. (591 aa)
BCAR1BCAR1 isoform 1. (849 aa)
CR201_G0048356Piezo-type mechanosensitive ion channel component. (1806 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
CR201_G0033575GIT1 isoform 13. (542 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (502 aa)
BAIAP2BAI1 associated protein 2. (521 aa)
P4HBProtein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (508 aa)
RAC3RAC3 isoform 1. (192 aa)
SRCIN1SRCIN1 isoform 1. (1233 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
ABI3ABI3 isoform 1. (366 aa)
PPP1R9BPPP1R9B isoform 1. (729 aa)
ITGB3Integrin beta. (788 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1299 aa)
SLC39A6Zinc transporter ZIP6; May act as a zinc-influx transporter. (742 aa)
APC2APC2 isoform 1. (2148 aa)
DNM2DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
ENSPPYP00000010854annotation not available (137 aa)
MYO9BMYO9B isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2099 aa)
CD177CD177 isoform 1. (437 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
KPTNKPTN isoform 1. (435 aa)
SPEF1SPEF1 isoform 2. (159 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
ITSN1ITSN1 isoform 4. (1610 aa)
NF2Neurofibromin 2. (590 aa)
RAC2Rac family small GTPase 2. (192 aa)
PARVBParvin beta. (334 aa)
CAPGCapping actin protein, gelsolin like. (348 aa)
ACTG2ACTG2 isoform 3. (378 aa)
ANTXR1ANTXR1 isoform 1. (215 aa)
CCDC88ACCDC88A isoform 1. (1797 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1493 aa)
NRBP1Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (573 aa)
LOC100449402Uncharacterized protein LOC100449402. (79 aa)
ACTR3Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] (418 aa)
ENSPPYP00000014325LOW QUALITY PROTEIN: polyadenylate-binding protein 1. (270 aa)
DPP4DPP4 isoform 1; Belongs to the peptidase S9B family. (766 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
NCKAP1NCK associated protein 1. (1134 aa)
ITGAVITGAV isoform 2; Belongs to the integrin alpha chain family. (1041 aa)
ALS2ALS2 isoform 1. (1638 aa)
ABI2ABI2 isoform 1. (551 aa)
RAPH1RAPH1 isoform 10. (1303 aa)
ARPC2Actin-related protein 2/3 complex subunit 2; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promot [...] (300 aa)
VIL1VIL1 isoform 1. (839 aa)
ENSPPYP00000014963annotation not available (78 aa)
FGD5FGD5 isoform 2. (1462 aa)
PLXND1PLXND1 isoform 1. (1818 aa)
MYLKMYLK isoform 5. (1913 aa)
ARHGAP31Rho GTPase activating protein 31. (1447 aa)
BRK1BRK1 isoform 1. (108 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. (349 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
CLRN1CLRN1 isoform 2. (232 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (759 aa)
RUFY3Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. (620 aa)
PTPN13PTPN13 isoform 2. (2426 aa)
PKD2PKD2 isoform 1. (968 aa)
UNC5CUNC5C isoform 1. (931 aa)
KLHL2KLHL2 isoform 2. (593 aa)
PALLDPALLD isoform 1. (1101 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pa [...] (888 aa)
SORBS2SORBS2 isoform 7. (1298 aa)
FAT1FAT1 isoform 1. (4591 aa)
MYO10MYO10 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa)
ENSPPYP00000017278annotation not available (564 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
MCCMCC isoform 3. (829 aa)
PDLIM4PDZ and LIM domain 4. (330 aa)
CTNNA1CTNNA1 isoform 1. (905 aa)
DPYSL3Dihydropyrimidinase like 3. (570 aa)
ABLIM3ABLIM3 isoform 2. (705 aa)
DBN1DBN1 isoform 4. (632 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
ENSPPYP00000018135Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (503 aa)
NEDD9NEDD9 isoform 1. (834 aa)
CARMIL1CARMIL1 isoform 2. (1366 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
FGD2FGD2 isoform 2. (655 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity); Belongs to the SCAR/WAVE family. (560 aa)
TIAM2TIAM2 isoform 10. (1675 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
FSCN1FSCN1 isoform 3. (444 aa)
RAC1Rac family small GTPase 1. (211 aa)
LIMK1LIMK1 isoform 2. (468 aa)
MYO1GMYO1G isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1009 aa)
DBNLDBNL isoform 9. (430 aa)
WASLWASL isoform 1. (505 aa)
FSCN3Fascin. (498 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (513 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PTK2BPTK2B isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
STMN2Stathmin; Belongs to the stathmin family. (179 aa)
PABPC1Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] (636 aa)
SCRIBSCRIB isoform 2. (1472 aa)
TESK1TESK1 isoform 2. (369 aa)
DOCK8DOCK8 isoform 2; Belongs to the DOCK family. (2024 aa)
ABITRAMProtein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons; Belongs to the ABITRAM family. (181 aa)
GSNGSN isoform 1. (732 aa)
TSC1TSC1 isoform 8. (1157 aa)
ENSPPYP00000022338Uncharacterized protein LOC112130482. (78 aa)
NHSNHS actin remodeling regulator. (1474 aa)
DMDDMD isoform 3. (3618 aa)
CR201_G0042601-2WASF2 isoform 1. (493 aa)
FGD1FGD1 isoform 1. (961 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (539 aa)
AMOTAMOT isoform 3. (1088 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
ENSPPYP00000023282annotation not available (191 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
ILKIntegrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa)
ARAP3ARAP3 isoform 1. (830 aa)
APCAdenomatous polyposis coli protein isoform X2. (2861 aa)
ITGB1BP1Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling [...] (200 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
CAPRIN1CAPRIN1 isoform 1. (410 aa)
SNX2Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (523 aa)
CR201_G0010942Diacylglycerol kinase. (919 aa)
CR201_G0011084CD44 isoform 1. (351 aa)
PARVAPARVA isoform 1. (412 aa)
APBB1APBB1 isoform 1. (800 aa)
INPPL1INPPL1 isoform 2. (1249 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
RDXRDX isoform 3. (604 aa)
PTPROPTPRO isoform 5. (1151 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (766 aa)
AVILAVIL isoform 2. (819 aa)
RAB3IPT0046992 isoform 1. (460 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (262 aa)
ACTA1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
CDC42BPANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1690 aa)
ENAHENAH isoform 1. (579 aa)
SRGAP2SLIT-ROBO Rho GTPase activating protein 2. (1071 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA [...] (151 aa)
SCYL3SCY1 like pseudokinase 3. (742 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
RAB13RAB13 isoform 2. (203 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa)
CTTNBP2NLCTTNBP2 N-terminal-like protein. (638 aa)
PKN2PKN2 isoform 1. (984 aa)
ANGPTL3Angiopoietin like 3. (463 aa)
PHACTR4Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to [...] (687 aa)
CR201_G0042601WASF2 isoform 2. (325 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
EPHA2EPHA2 isoform 1. (959 aa)
PDPNPDPN isoform 1. (236 aa)
PLEKHG5PLEKHG5 isoform 5. (905 aa)
APBB1IPAPBB1IP isoform 1. (645 aa)
ABI1Abl interactor 1. (481 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (887 aa)
CTNNA3CTNNA3 isoform 1. (895 aa)
ACTA2ACTA2 isoform 5. (399 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
FGD6FGD6 isoform 2. (1428 aa)
ABLIM1ABLIM1 isoform 1. (771 aa)
SHTN1Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] (647 aa)
CTTNCTTN isoform 1. (508 aa)
CORO1BCoronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity); Belongs to the WD repeat coronin family. (510 aa)
CFL1CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. (165 aa)
FAM89BFamily with sequence similarity 89 member B. (176 aa)
STX3STX3 isoform 3; Belongs to the syntaxin family. (289 aa)
CTNND1CTNND1 isoform 19. (968 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (14%) [HD]