STRINGSTRING
PALM PALM ACTN2 ACTN2 ACTA1 ACTA1 ENAH ENAH CR201_G0042066 CR201_G0042066 UBE2Q1 UBE2Q1 VCAM1 VCAM1 DNALI1 DNALI1 CDC42 CDC42 PDPN PDPN MYO3A MYO3A ABI1 ABI1 ACTA2 ACTA2 MORN4 MORN4 SHTN1 SHTN1 TBC1D10C TBC1D10C INPPL1 INPPL1 RDX RDX FGD4 FGD4 KITLG KITLG TRPV4 TRPV4 SPATA13 SPATA13 LCP1 LCP1 FARP1 FARP1 ARF6 ARF6 SYNE2 SYNE2 CYFIP1 CYFIP1 ACTC1 ACTC1 MYO5A MYO5A CR201_G0014777 CR201_G0014777 TUBB3 TUBB3 SCIMP SCIMP FXR2 FXR2 SLC9A3R1 SLC9A3R1 BAIAP2 BAIAP2 SRCIN1 SRCIN1 IGF2BP1 IGF2BP1 ITGA3 ITGA3 PPP1R9B PPP1R9B ITGB3 ITGB3 ENSPPYP00000010854 ENSPPYP00000010854 VASP VASP CR201_G0029663 CR201_G0029663 TTYH1 TTYH1 SPEF1 SPEF1 SRC SRC CXADR CXADR NF2 NF2 ACTG2 ACTG2 ANTXR1 ANTXR1 ERMN ERMN MYO3B MYO3B ITGAV ITGAV MYO1B MYO1B ABI2 ABI2 RAPH1 RAPH1 MAP2 MAP2 VIL1 VIL1 EPHA4 EPHA4 ARL4C ARL4C GAP43 GAP43 TWF2 TWF2 ACPP ACPP EPHB1 EPHB1 NLGN1 NLGN1 FXR1 FXR1 UBE2K UBE2K RUFY3 RUFY3 UNC5C UNC5C GPM6A GPM6A FAT1 FAT1 MYO10 MYO10 IQGAP2 IQGAP2 TENM2 TENM2 RIPOR2 RIPOR2 MYO6 MYO6 UTRN UTRN TIAM2 TIAM2 EZR EZR FSCN1 FSCN1 FZD9 FZD9 MYO1G MYO1G OSBPL3 OSBPL3 CR201_G0010042 CR201_G0010042 FSCN3 FSCN3 PODXL PODXL CDK5 CDK5 FZD3 FZD3 ADGRA2 ADGRA2 B4GALT1 B4GALT1 NINJ1 NINJ1 ABITRAM ABITRAM WDR34 WDR34 DMD DMD MSN MSN FGF13 FGF13 FMR1 FMR1 MTM1 MTM1 NGDN NGDN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PALMPALM isoform 3. (368 aa)
ACTN2ACTN2 isoform 1. (887 aa)
ACTA1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
ENAHENAH isoform 1. (579 aa)
CR201_G0042066C1orf226 isoform 2. (695 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
DNALI1Dynein axonemal light intermediate chain 1. (280 aa)
CDC42Cell division cycle 42. (191 aa)
PDPNPDPN isoform 1. (236 aa)
MYO3AMYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1575 aa)
ABI1Abl interactor 1. (481 aa)
ACTA2ACTA2 isoform 5. (399 aa)
MORN4MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. (146 aa)
SHTN1Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] (647 aa)
TBC1D10CTBC1D10C isoform 5. (435 aa)
INPPL1INPPL1 isoform 2. (1249 aa)
RDXRDX isoform 3. (604 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (766 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (262 aa)
TRPV4TRPV4 isoform 2; Belongs to the transient receptor (TC 1.A.4) family. (699 aa)
SPATA13SPATA13 isoform 1. (1274 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
FARP1FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). (1045 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SYNE2SYNE2 isoform 1. (6862 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
MYO5AMYO5A isoform 5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1795 aa)
CR201_G0014777CIB1 isoform 1. (190 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
SCIMPSCIMP isoform 1. (145 aa)
FXR2FXR2 isoform 2. (658 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
BAIAP2BAI1 associated protein 2. (521 aa)
SRCIN1SRCIN1 isoform 1. (1233 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
PPP1R9BPPP1R9B isoform 1. (729 aa)
ITGB3Integrin beta. (788 aa)
ENSPPYP00000010854annotation not available (137 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
CR201_G0029663AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (749 aa)
TTYH1Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (430 aa)
SPEF1SPEF1 isoform 2. (159 aa)
SRCTyrosine-protein kinase. (553 aa)
CXADRCoxsackievirus and adenovirus receptor homolog; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induc [...] (365 aa)
NF2Neurofibromin 2. (590 aa)
ACTG2ACTG2 isoform 3. (378 aa)
ANTXR1ANTXR1 isoform 1. (215 aa)
ERMNErmin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). (284 aa)
MYO3BMYO3B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1306 aa)
ITGAVITGAV isoform 2; Belongs to the integrin alpha chain family. (1041 aa)
MYO1BMYO1B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (974 aa)
ABI2ABI2 isoform 1. (551 aa)
RAPH1RAPH1 isoform 10. (1303 aa)
MAP2Microtubule-associated protein. (1770 aa)
VIL1VIL1 isoform 1. (839 aa)
EPHA4EPHA4 isoform 2. (927 aa)
ARL4CADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family. (201 aa)
GAP43Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (238 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. (349 aa)
ACPPAcid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (421 aa)
EPHB1EPHB1 isoform 1. (1057 aa)
NLGN1NLGN1 isoform 2. (823 aa)
FXR1FMR1 autosomal homolog 1. (621 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
RUFY3Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. (620 aa)
UNC5CUNC5C isoform 1. (931 aa)
GPM6ANeuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and re [...] (257 aa)
FAT1FAT1 isoform 1. (4591 aa)
MYO10MYO10 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
TENM2TENM2 isoform 3. (2577 aa)
RIPOR2T0162759 isoform 1. (1097 aa)
MYO6MYO6 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1294 aa)
UTRNUTRN isoform 2. (3433 aa)
TIAM2TIAM2 isoform 10. (1675 aa)
EZREZR isoform 1. (586 aa)
FSCN1FSCN1 isoform 3. (444 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MYO1GMYO1G isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1009 aa)
OSBPL3Oxysterol-binding protein; Belongs to the OSBP family. (887 aa)
CR201_G0010042PPP1R9A isoform 2. (1098 aa)
FSCN3Fascin. (498 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (513 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ADGRA2ADGRA2 isoform 2; Belongs to the G-protein coupled receptor 2 family. (1328 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
NINJ1NINJ1 isoform 1. (152 aa)
ABITRAMProtein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons; Belongs to the ABITRAM family. (181 aa)
WDR34WDR34 isoform 1. (532 aa)
DMDDMD isoform 3. (3618 aa)
MSNMSN isoform 6. (577 aa)
FGF13Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa)
FMR1Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] (590 aa)
MTM1Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa)
NGDNNGDN isoform 2. (353 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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